ID A0A2T4A3J8_TRIHA Unreviewed; 724 AA.
AC A0A2T4A3J8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 03-MAY-2023, entry version 13.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:PTB51631.1};
GN ORFNames=M431DRAFT_484607 {ECO:0000313|EMBL:PTB51631.1};
OS Trichoderma harzianum CBS 226.95.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=983964 {ECO:0000313|EMBL:PTB51631.1, ECO:0000313|Proteomes:UP000241690};
RN [1] {ECO:0000313|EMBL:PTB51631.1, ECO:0000313|Proteomes:UP000241690}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 226.95 {ECO:0000313|EMBL:PTB51631.1,
RC ECO:0000313|Proteomes:UP000241690};
RG DOE Joint Genome Institute;
RA Aerts A., Atanasova L., Chenthamara K., Zhang J., Grujic M., Henrissat B.,
RA Kuo A., Salamov A., Lipzen A., Labutti K., Barry K., Miao Y., Rahimi M.J.,
RA Shen Q., Grigoriev I.V., Kubicek C.P., Druzhinina I.S.;
RT "Multiple horizontal gene transfer events from other fungi enriched the
RT ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead
RT plant biomass.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
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DR EMBL; KZ679685; PTB51631.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T4A3J8; -.
DR STRING; 983964.A0A2T4A3J8; -.
DR OrthoDB; 1459320at2759; -.
DR Proteomes; UP000241690; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR18866:SF33; METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000241690}.
FT DOMAIN 32..485
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 148..348
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 640..715
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 724 AA; 79223 MW; C3CD78B3A2747643 CRC64;
MRSLRANRLS LRPVPRFLST SSASSTLPKP AALSSVLIAN RGEIAIRINK TAERMGIKAT
TVYTDVDANS WHASSGFQSF GLGPANGYLD GEKIIALAKK HGIQALHPGY GFLSENYKFV
ERCEEEGIVF VGPPATAMAD MGNKARSKEI MNAANVPCVP GYHGSEQGEA ELLAYAKEIT
FPVLLKSVRG GGGKGMRIVM KEDEFLTQLK SARAEAKASF GDGGEVMLVE KYIVRPRHVE
VQVFADKHGN TVALGERDCS VQRRHQKVLE ESPAPDLDEV TRQDLWDKAR KAAEAVGYVG
AGTVEFILDK DSGKFYFMEM NTRLQVEHPV TEMVTGLDLV EWQFRIAAGE KLPLTQAEVE
EQMNQRGAAI EARIYAENPE KGFMPDSGKL VHAVLLDAAK NDPDIRLDWG FGSGSVVSEA
YDGMIAKLIV RGDDRETAIA KLASALRNFE IVGLSTNVEF LKRMCESEAF IAGDVETGFI
DKWREELFKP RRINNEVFAQ AALGVLSNQL QNIGSSPHGQ SLGFGNTNST SERKLAFKVL
DGYSEKEGEI VEAAVSQTGH NLYSVTISRK GEEPQLFSNI ISEPTIEGEV TKLKSRFPAE
RIESTVVPQE NGTETKLAIF QHGLKTDLAL LPPSWYEKAL GLKELTASVA APMPCKILKN
EVTEGQTVKK GEPLVVIESM KMETVIRSPQ DGVIKKLAHK EGDICKAGTV LVLFEEDASK
EESS
//
