ID A0A2T4A6R6_TRIHA Unreviewed; 651 AA.
AC A0A2T4A6R6;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 12.
DE RecName: Full=3'-5' exonuclease domain-containing protein {ECO:0000259|SMART:SM00474};
GN ORFNames=M431DRAFT_89705 {ECO:0000313|EMBL:PTB52775.1};
OS Trichoderma harzianum CBS 226.95.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=983964 {ECO:0000313|EMBL:PTB52775.1, ECO:0000313|Proteomes:UP000241690};
RN [1] {ECO:0000313|EMBL:PTB52775.1, ECO:0000313|Proteomes:UP000241690}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 226.95 {ECO:0000313|EMBL:PTB52775.1,
RC ECO:0000313|Proteomes:UP000241690};
RG DOE Joint Genome Institute;
RA Aerts A., Atanasova L., Chenthamara K., Zhang J., Grujic M., Henrissat B.,
RA Kuo A., Salamov A., Lipzen A., Labutti K., Barry K., Miao Y., Rahimi M.J.,
RA Shen Q., Grigoriev I.V., Kubicek C.P., Druzhinina I.S.;
RT "Multiple horizontal gene transfer events from other fungi enriched the
RT ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead
RT plant biomass.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KZ679683; PTB52775.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T4A6R6; -.
DR STRING; 983964.A0A2T4A6R6; -.
DR OrthoDB; 318506at2759; -.
DR Proteomes; UP000241690; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd06141; WRN_exo; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR13620; 3-5 EXONUCLEASE; 1.
DR PANTHER; PTHR13620:SF104; EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000241690}.
FT DOMAIN 202..390
FT /note="3'-5' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00474"
FT REGION 82..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..480
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..519
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 651 AA; 72167 MW; 835908D24442CB83 CRC64;
MHSCLSAQVL GSCRGSLVRA MSYHHTSQLW SSQFGVRFGA LANVRQESTA STSIHTSALG
GDEIRTDGPV ISAEVGLYTT DVTPDPLPSF PRSRSPRRAP IALPPRSTDA QRPPIALPDP
NVATNSKDAS SKDASAKENA AAPSADKKKI VVEPPSTSLE FSISKKEFLA ARAAIPGTPE
AHWSYTMYHR TGENGKVDNV KVHYCESKAT TERVCSEYFL NEDVIGLDLE WMKWARKTDG
PRQNVSLIQI ASPSRIALIH VAVFTEKEDF LGPSFRKMME NPNVSKVGVN IIPDCTRLKT
HLGVTVRGVF ELSHLYRVVK YLPETPNLVH KGLVSLATQV EDQLLLPLFK GDLVRTGNWM
RRLSSQQINY AASDAYAGLQ LYYVLEEKRK ALVPCPPRPH HAELRLPIPL PDPPAPPAVE
KTEDDAAAVD PTTATSADTT ASTYKRKNYK PKDPKLEDSK PQDPKLEDPN PEDSKPKRQL
PKTFKPKLPA SEAAASGDSA TKAPKAKRQR PPKAPDTRDA RVIAAEAEMK AYNDAYTAAN
STWPVTTPVR IRAYYIWYRN EDLCPADIAA LLRDPPLLTS TVAAYIVDAI QTEKFPYPLG
RLHKEVVCHI DLEKPYMYKY KSFCEECSKA VKLDHNNEET KQTEVKPDEQ K
//
