ID A0A2T4A8W2_TRIHA Unreviewed; 3216 AA.
AC A0A2T4A8W2;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Vacuolar protein sorting-associated protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=M431DRAFT_6947 {ECO:0000313|EMBL:PTB53423.1};
OS Trichoderma harzianum CBS 226.95.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=983964 {ECO:0000313|EMBL:PTB53423.1, ECO:0000313|Proteomes:UP000241690};
RN [1] {ECO:0000313|EMBL:PTB53423.1, ECO:0000313|Proteomes:UP000241690}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 226.95 {ECO:0000313|EMBL:PTB53423.1,
RC ECO:0000313|Proteomes:UP000241690};
RG DOE Joint Genome Institute;
RA Aerts A., Atanasova L., Chenthamara K., Zhang J., Grujic M., Henrissat B.,
RA Kuo A., Salamov A., Lipzen A., Labutti K., Barry K., Miao Y., Rahimi M.J.,
RA Shen Q., Grigoriev I.V., Kubicek C.P., Druzhinina I.S.;
RT "Multiple horizontal gene transfer events from other fungi enriched the
RT ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead
RT plant biomass.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR EMBL; KZ679682; PTB53423.1; -; Genomic_DNA.
DR STRING; 983964.A0A2T4A8W2; -.
DR OrthoDB; 199953at2759; -.
DR Proteomes; UP000241690; Unassembled WGS sequence.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR017148; VPS13_fungi.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF93; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 1.
DR Pfam; PF06650; VPS13_VAB; 1.
DR PIRSF; PIRSF037235; VPS13_fungi; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000241690};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2..115
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 139..380
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 591..828
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1988..2563
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 2811..2987
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT DOMAIN 3085..3187
FT /note="Intermembrane lipid transfer protein VPS13 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21679"
FT REGION 836..870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1405..1432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1582..1629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1751..1803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..868
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1415..1430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1584..1629
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1779..1803
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3216 AA; 360029 MW; 3B80F8D25F2F456C CRC64;
MLEGLVAGLL NRFLGMYVKN FDPTQLKVGI WSGDVKLRNL ELRREALDQL KLPINVIEGH
LGELTLYIPW SNIRGAPVKV FIEDVYLLAS PKEEAEYDED EEQRRKHRLK MEKLESAELL
KERNKAGMSQ EEQKKNQSFA QSLATKITDN LQITVKNIHI RYEDSISAPG HPFALGFTLE
EFSAVSADGQ WTPSFIQQSS TTTHKLATLG SLAVYWNTDS ELFSSGRQTG NDSQGTMTHS
DMVDKFKSML TKIHDPDSSN QFILKPVSGQ AKIELDKSGA IEVPKFKATL LFDEIGVVLD
DDQYRDALMM VDLFHYFIRH QEYKALKPKG VSPKEDPRAW LLFAGNAILG KIHDRNRKWS
WDYFRERRDD RRRYIELFKK KKQGLQLEAN ESSDLDKLEF KLSYEDLRFW RSLARNQLKK
ENAAALSRQP QQPQQQGWVA WMWGSKPTGT IQENEENTQM TEEQRKELYD MIDWDEKAAL
AESVDVPREA VNMCIEAALS TGSFTLKKSP HHNTMDLLSL HFDLFKAKAL QRKDSVLASV
SLGGLRINDG TTPDSLYPEI VRVKDAQKRK PISLEELETA EEEPFFEFEI EQNPLEREGD
IAVVGKLKPL EVVWNPNFVV GIVDFFRPPE RHMESIAALM ETAGATVEGI REQTRVGLEF
ALEEHKTINA ELDLQAPLII IPVSITTEHS TCLVVDAGHM HVNSQLVDQE TLAEIQSKQR
QSYNEEDFKR LESAMYDRFI VKFTSTQVLI GPSIEETKAQ LTSKPGDRGS QLHVVEEINV
DFVVEMSILP KAPNLTKFKV SGHLPMLHAT VSDAKYKNLM QIIDVAIPKF HSEAEQKAVQ
SGATTQARPS SRHSSRPRLA SNASSRSALR SMRDRRQSAF PFLQSSTAVI LEDIDDDDDD
FEDAEDGTHG EQFRMQQRSF EFNFKVDTLK GSLYRSDPSR SKQDVLLVEL VAERFDLSFY
TRPYDMAAEV SLGSVTMDDF VDNPPAEFKS IVSSGDREDL QAGRSLVHVK FVRVNRQSPE
FMPVYEGVET NITTTISTIN LVVTRKTLLT LLDFILVTFT NNNADEQMGQ SGPSQIDNAA
EDDVAVDSVV VQEPKQNANA TSSIRVKVEL KSIRLILNND GIKLATLSFN QGDAGIFLRG
QTMRISAKLG DLSLIDDVNL GVSEDSHLRK LVTIQGDDLA DFRYETFDPE NPQAYPGYDS
SIFLRAGSVK VNFVEEPFRK IIDFLVKFGK MQALYNAARQ VALNRANQIQ QSPSKIKFDV
VVNTPIVVFP RAVIPGRPHR DLITAYLGEI YAQNKFVPLD DSHGATIAMK ISAGIRNIRL
TSDFHYADNK SEELEMIDHV DLGFHITHAE HVEGVKRPET EIEGTVSDIK LQLTQHQLKF
LMEISRSVPA AFSGDGDANA EAERLVDDQT LERAKGSPSD GQSNGNEQPL ISLGPELGSL
SDAWTKLDFV FNVNTVGLEV IMAPEEGPVN DVAACSLSRF SLDDTHVKTR MMSDGSIEAE
VLVRSFTIYD TRPRDTNKYR RIMTSSNKEA QQLMASVTMS GGTERSVIAM ATIDSPRVIF
ALDYLFAIQK FATEGLTMEE ASPIDTESML SSPEESDTES TQVSYSQRPS ISSPRPSISA
AEASLETQPK AQTSMDISFR VNLVDAQVIL IANPLSSSSE AIVLGIRQVL LSQQHALTFQ
ISQIGMFLCR MDKFETSRLR IIDDFSIQMS MNNPQPNSTD INIEIEPLIL RLSLRDILLA
LQIIGRAGEL SGTDSKVPKE SAADQKAKQL RSKTRHRASS GRGGASTTAK SSHAARTTTT
AASSRAVTYA ERYSAPAKNE NLSATVDGVR IVLIGDLHEL PILDIGIQNF TAVAENWSSN
LKAEAAIDMY SNVYNFSKSS WEPLLEPWQV GLGVAKDPIT SFLSVDVVSK KTFDITVTTA
TIALASKSFD FLTAAENVLE KPRGVEAPYR IRNYTGFNAI VHSKSPTNSE PITLHLEDGQ
EAPWSFEQWE KMREMILADS QPNDVGIQLE ASGFDLIRNV RLNREGEFLY SLRPKTDNIL
HKLCVEVSLG ADNVKYVTLR SPLVVENATQ IPVELGIYDA QEGHLLKIEK IAPGDSRPAP
VGAVYEKRVL VRPDSGFGYQ WSAEQLWWKD LLKRPTRQIV CKGDSGDPFY FQAHASFDNS
SPITRSYPYM KIKLSAPVTL ENLLPYDFKY RIYDKNTKKD WSNFLRKGGV SPVHVVELSH
LLLLNVDMQD TVFKPSDFAI INSGTNEDFR RESRIVVKDD QGLSLNLSLH YHKIPNSGGA
FKVTVYSPYV ILNKTGLDLT VRAKSFLQQA KSAAGQFPLI NTSDHDRPKA LPFMFSFGND
DTRNRALLRV ADSEWSKPQS FDAIGSTSEV ILNSGSNRNK EIHLGLTIQS GEGKYKMTKV
VTIAPRFVLK NKLDEEILIR EPSSSGYMTL GPGALQPLHF MQNSTVKQLC LCFPGMNNQW
TSPFNIADIG TTHVKIAKAG QRQRLIRVEI LVEDSTIFLH FSVETKNWPF SMRNESDTEF
TFYQANPTVE EDDVVDRSGW KPIRYRLPPR SIMPYAWDFP AAKFREVVIS TAGKERHVKL
AEIGNQFPMK FTSQNGTQKI IDINVAADGP TQTLILSNFR PSQSLYRQKT LSRTNTGPEA
FEVKDQDTDA TFVAQLKLSG IGISFINAQL KELAYVTFRD VQFRITDSPV VQTVSLAIKW
MQIDNQLYGG LFPMVLYPSV VPQKAQEIEA HPSLHAMVSR VKDDSYGVLY IKYASILLQQ
MTVDLDEDFV FALLDFSNVP GASWSSEVEE GQLCDEDLDI PEPSQRDTGQ DIYFEVLNIQ
PMQVDLSFMR TERINAEDKT SSHNPLMFFL NVMTMAIGNI NDAPVRFNAL ILENVRVSMQ
ILIQNITNHY SQEVMYQIHK ILGSADFLGN PVGLFNNISS GVNDIFYEPY QGLILSDRPE
EFGMGIAKGA ASFAKKTVFG FSDSFSKFTG SLSKGLAAAS MDKQFQDRRR ITRARNRPKH
ALYGVTAGAN SLFTSVASGV GGLALKPLEG AEQEGALGFF KGVGKGVLGL ATKPAVGILD
MASNVSEGIR NTTTVFDGAE LERTRYPRFV PNDGIVRPFN PREALGQYWL KQVDNGRYFD
EQYIGHLELP KEDMVVMVTF ARILLIRSRR LTSEWDVPLK DVQTIAKERT GISLALRDGA
NGPFIPVGGG SERGFLYKML GVAVEEFNRR FRGGER
//
