ID A0A2T4BJT2_9HYPO Unreviewed; 831 AA.
AC A0A2T4BJT2;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Mechanosensitive ion channel protein {ECO:0000256|PIRNR:PIRNR017209};
GN ORFNames=BBK36DRAFT_1165779 {ECO:0000313|EMBL:PTB69521.1};
OS Trichoderma citrinoviride.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=58853 {ECO:0000313|EMBL:PTB69521.1, ECO:0000313|Proteomes:UP000241546};
RN [1] {ECO:0000313|Proteomes:UP000241546}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TUCIM 6016 {ECO:0000313|Proteomes:UP000241546};
RG DOE Joint Genome Institute;
RA Atanasova L., Chenthamara K., Zhang J., Grujic M., Henrissat B., Kuo A.,
RA Aerts A., Salamov A., Lipzen A., Labutti K., Barry K., Miao Y.,
RA Rahimi M.J., Shen Q., Grigoriev I.V., Kubicek C.P., Druzhinina I.S.;
RT "Multiple horizontal gene transfer events from other fungi enriched the
RT ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead
RT plant biomass.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|PIRNR:PIRNR017209}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|PIRNR:PIRNR017209}.
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DR EMBL; KZ680208; PTB69521.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T4BJT2; -.
DR OrthoDB; 1362946at2759; -.
DR Proteomes; UP000241546; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR016688; MscS-like_plants/fungi.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR PANTHER; PTHR31323:SF15; MECHANOSENSITIVE ION CHANNEL PROTEIN MSY1; 1.
DR PANTHER; PTHR31323; MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR PIRSF; PIRSF017209; Memb_At2g17000_prd; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR017209};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR017209};
KW Reference proteome {ECO:0000313|Proteomes:UP000241546};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 134..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 425..460
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..831
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 831 AA; 93637 MW; 582B292156FDA20A CRC64;
MSRIEEQFSE SDDGKVDEPY DEKYEAPTLD TFNTLNTLAP THDSNGGMTP TNQRAEANRL
NDDLELLRAE RLVSNQEHDQ ASKARTRNRH HNPEPEDAFN QHNVEPVLEK KKNTDAALYK
LWLFISKFPR FFRYIIYLIP GAALLLAPVL LGTFRFNGTE HAVGGTGGVY VMWFGIWLEI
VWCSLWVTRM ITNLIPPLFH AVARVVGSTN APKWRDIGQR LELHTAMFLW FLAILVSFKP
TMDSHRAPVP DGESGKVHIH WISVVNKVII SLFVLATLNF VEKILIQWIA QSFHQRTYAT
RIENNKADIR QLVCLFEYAK KQLESTDSFW KGSGGNASGS GMQTPMRTLH NNARHVLGKV
GHVAGRVGND ILGRKGADNN HPRKIVAELL RNTASAHTLA RLIYRSVVRE GRETVHLEDL
QVAFESMEEA EAAFSMFDKD MNGDISMDEF EAVCNEIHLE KKAIAASLKD LDSVIKKLDK
VFLFLIVVIA IIVFVAILSD STAAGLASAG SSILGLAWML QATAQEFLQS IIFVFIKHPF
DVGDRVTIYG NTGATLTGDD YYVTEISLLY TEFKKMQGHI VQAPNSILNT LFILNQRRSN
GLSDVIPLEM RFGTPGHLIE ELKARMLEFV KNNKRDYQPS IITEMTGFNQ VRSCTMNMVF
FHKSSFQNEL LRLNRHNKFV TELMYQMVQV GIEAPLRVDP GGSREHPLYW ANLPAPPAYN
NNPNPNDGTP QGRPRASSST RSIRSVPNQE PVTGGFQDVF EKRREHVHMQ RMASIREKER
GLQEEEEATA RASTTALAPV TSADSQTQSR SRIFGRARSG TRSAQSNRDM V
//
