ID A0A2T4GDT9_FUSCU Unreviewed; 737 AA.
AC A0A2T4GDT9;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=DNA mismatch repair protein Mlh1 {ECO:0000313|EMBL:PTD01610.1};
GN ORFNames=FCULG_00010010 {ECO:0000313|EMBL:PTD01610.1}, HYE67_006197
GN {ECO:0000313|EMBL:QPC63966.1};
OS Fusarium culmorum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=5516 {ECO:0000313|EMBL:PTD01610.1, ECO:0000313|Proteomes:UP000241587};
RN [1] {ECO:0000313|EMBL:PTD01610.1, ECO:0000313|Proteomes:UP000241587}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PV {ECO:0000313|EMBL:PTD01610.1,
RC ECO:0000313|Proteomes:UP000241587};
RA Schmidt R.;
RT "Fusarium culmorum secondary metabolites in fungal-bacterial-plant
RT interactions.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QPC63966.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Class2-1B {ECO:0000313|EMBL:QPC63966.1};
RA Yuan Z.;
RT "The chromosome-scale genome resource for two endophytic Fusarium species:
RT F. culmorum and F. pseudograminearum.";
RL Submitted (NOV-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; PVEM01000028; PTD01610.1; -; Genomic_DNA.
DR EMBL; CP064749; QPC63966.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T4GDT9; -.
DR OMA; ANYHVKK; -.
DR Proteomes; UP000241587; Unassembled WGS sequence.
DR Proteomes; UP000663297; Chromosome 3.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03483; MutL_Trans_MLH1; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000241587}.
FT DOMAIN 258..377
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 390..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 737 AA; 81900 MW; BA6B5AEE7490236D CRC64;
MATDADVDMG GVPSVDEIHN VVPSGTKRKA ESLTEGAGAP RRIKALDPNV VNKIAAGEII
VAPVHALKEL IENAVDAGAT SLDVLAKEGG LKLLQITDNG CGIQKDDLAI LCERHTTSKI
TTFEDLSAIE TYGFRGEALA SISHIAHLSV TTKTKDSDLA WRAHYYEGKL APAKPGQSAE
PKGVAGRQGT QITVEDLFFN IVTRRRAFRS PSDEFNKIID MVGRYAVHCK GVGFTCKKAG
EASTNLSIQA HATVIDRIRQ IHGSAVANEL LEFSVSEARW GFRAEGYTTN ANYSVKKTTI
LLFINHRCVE STHIKKAVEQ TYANFLPKNG HPFIYLSLEI DPARVDVNVH PTKREVHFLN
EDEIIQSICA AIESKLAAVD TSRTFMTQTL LPGAKATEST SQAESDGTPS RRTPATKKRR
YSNDLVRTDT AERKITSMFA RAGPSESTGS MDRAGDTIPI HEPLEYETVD RELVQCRLNS
VKYLREEVRE DMHLELTEIF ANHTFVGVVD EQRRLAAIQG GVKLYLIDYG RTCYEYFYQL
GLTDFGNFGT IKFAPALDLR ELLRTAAAVE KSLITSPDED FDTEALADRV ADQLIERREM
LLEYFSLEIS PTGELISLPL LIKGYTPPLV KLPRFLLRLG PGVDWTDEQA CFDSFLQEMA
TFYVPEKLPT LPGDVESLRE EVISTEMRAR RQHVRHAVEH VFFPAFKARL VATKSLMEDA
VLEVANLKGL YRVFERC
//
