ID A0A2T4GI06_FUSCU Unreviewed; 3179 AA.
AC A0A2T4GI06;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Vacuolar protein sorting-associated protein {ECO:0000256|PIRNR:PIRNR037235};
GN ORFNames=FCULG_00009158 {ECO:0000313|EMBL:PTD03207.1};
OS Fusarium culmorum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=5516 {ECO:0000313|EMBL:PTD03207.1, ECO:0000313|Proteomes:UP000241587};
RN [1] {ECO:0000313|EMBL:PTD03207.1, ECO:0000313|Proteomes:UP000241587}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PV {ECO:0000313|EMBL:PTD03207.1,
RC ECO:0000313|Proteomes:UP000241587};
RA Schmidt R.;
RT "Fusarium culmorum secondary metabolites in fungal-bacterial-plant
RT interactions.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the transfer of lipids between membranes at
CC organelle contact sites. May play a role in mitochondrial lipid
CC homeostasis. {ECO:0000256|PIRNR:PIRNR037235}.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545, ECO:0000256|PIRNR:PIRNR037235}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PTD03207.1}.
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DR EMBL; PVEM01000016; PTD03207.1; -; Genomic_DNA.
DR OMA; SGWRPIR; -.
DR Proteomes; UP000241587; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-UniRule.
DR GO; GO:0045324; P:late endosome to vacuole transport; IEA:UniProtKB-UniRule.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0045053; P:protein retention in Golgi apparatus; IEA:UniProtKB-UniRule.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR017148; VPS13_fungi.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF93; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 1.
DR Pfam; PF06650; VPS13_VAB; 1.
DR PIRSF; PIRSF037235; VPS13_fungi; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|PIRNR:PIRNR037235};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|PIRNR:PIRNR037235};
KW Reference proteome {ECO:0000313|Proteomes:UP000241587};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037235}.
FT DOMAIN 2..115
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 139..380
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 594..830
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1953..2527
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 2775..2951
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT DOMAIN 3049..3152
FT /note="Intermembrane lipid transfer protein VPS13 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21679"
FT REGION 841..874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1542..1591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1714..1775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1576..1591
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1722..1736
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1741..1756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3179 AA; 356963 MW; CF6531A17BF8F5F3 CRC64;
MLEGLVAGLL NRFLGMYVKN FDPAQLKVGI WSGDVKLRNL ELRREALDQL KLPINVMEGH
LGELTLVIPW SNLRGAPVKV FIQDVFLLAS PKEEAEYDQD EEDRRKQRLK MEKLDSAELL
KERNQEGLSQ EEQKKSQSFT SSLVTKIVDN VQVTVKNIHI RYEDSISAPG HPFALGVTLE
EFSAVSTDGQ WKPVFIQDSN TVTHKLATLG ALAVYWNTDS DLLGTGREAS ASSEDVMSHD
EMVAKFREMI GKDAQKNSNH QFILKPVNGQ AKIELDKSGD IMVPKFKANL LFEEIGVVLD
DDQYRDALMM VDLFHYFIRH QEYKRLQPKG IRPKEDPRAW LEFAGNAVIS KIHERNRKWS
WDYFRERRDD RKRYIELFKK RKQGQQMSSD ETDAINSLEW KLTYEDLRFW RSLARNQLKK
ENAEALKNQP QQPQQQQGWI SWVWGSKPQE TIEHNEENTQ MTEEQRQELY EAIDWDEKNA
IAEEVDMPRE AIKMCIETSL STGSFTLKKS PHDNAADLLS LHFDVFKAKA LQRKDSMLAN
VSLGGLRVND GTTPDSVYPE IVRVKDAPTN NQRKRLSLAE LEQPEEDPFF QFEFEQNPIE
REGDIAIVGK MKPLEVIWNP NFVVGIADFF RPPERHMESI TALMESAGAT VESIREQTRA
GLEFALEEHK TINAELDLQA PLIIVPVSIT TENSTCLIVD AGHIHVNSEL VDQGTMKEIQ
SKQKQTYSDE DLKKLESVMY DKFIVKLTST QVLIGPSVDE TKAQLVEKSD EAHLHVVEQI
NVDFVVETSI LPKAPNLTKF KVSGHLPMLH ATVSDTKYKN LMKVIDVAIP KFGGTSAERI
EQHREASRPR LKSNSSNRSR RKSQRERRQS TPFPFMQSET AVVLDDMDED DDDFEDATDG
GDSEQLKVQQ RIFEFKFKVD TLKGSLYRSD PDGRKPDALL VELVAERFDL EFYTRPFDMV
ADVSLGSVTV DDFVDNPSAE FKSIISSGDS QPRFPEFMSV YEGVEININA VVSTINLIVT
RKTLLTLLDF ILITFTNNNN NNQPNNNKAI LDDDDEDCES INTAVAVANE PQSTSSNGSI
RVKVDLKSIR LILNNDGIRL ATLSFNKADA GIFLRGNTMR ISAKLGDLSL VDDVNLGVSE
DSHLRQLVTI QGDDLADFRY ETFDATNPKA YPGYDSSVFL RAGSVKVNFV EEPFRKIVDF
LVKFGKMQAL YNAARQAAMN QANQLQQSPS RFKFDVVVNT PIVVFPRVQK PGQTERDVVT
AYLGEIYAQN KFTPLDDSED SEIAMKLSAV SEELEMIDHV DLGFNITYAE HRHGAKRPET
EIEGTMSDFN LRLTQYQVKF LLEISKSVPA AFAGEGGDKE EEAAKAVDEG TLQRARTANF
EDKSGDEKTL VDLGPELGSL GQEWTKLDLV FRVNTIGLEL INAEENEPVE DIAKSSLSRF
SLDDTKVKTR MLSDSSLEAE LLIRSFTIYD SRPRDTNKFR RIMSSMNKDV QQLMASVTIS
GGKEKSLIAM ATIDSPRVIF ALDYLFSIQK FAVEALAVDD SSPMDDESMA DNTPDESDAE
SMQVTLAGGA SRPRSELSRR QSEDVAKQGD NKEESSMSIA FRVNLVDAQV ILIANPLTSS
SEAVVLSIRQ MLLSKQHALT FQISEIGMFL CRMDKFETSR LRIIDDFSVQ LSMDGSKPQT
TDINVDIEPL VLRLSLRDIL LVLQIVSKAS ELSGNEPKQQ VKESPADQKA RELRNAGIKQ
RSASGRGQST IAGRSKVTAA SHAVTHGADT RGGKAPEQVA QQNYETLSAT VEGIRVVLIG
DVHELPILDI GIKNFKASAE NWSSNLKAET AIDLYSNVYN FAKSSWEPLL EPWQVGFGVA
KDPVSGLMSI DVASKKVFDV TITTASIALA SKSFQFLTSD EDVLDKPRGV EAPYRIRNYT
GFDVLVHSKS PTSEEPINLR LEDGQEAPWS FEHWEKMREN LLTESNQNNV SISLEGSGFD
PVKNVRLNRE GEYLYGLRPK ADDVLHRLCV DVELGTDNIK YVTFRSPLHV ENATEIPVEL
GIYDAQDGHL LKIEKINPGD SRPAPVGAVF EKRVLIRPDS GFGYQWSNDQ LYWRDLLKRP
TKQVVCKGEN GDPFYFQVHA RFDKANPLTK HYPYMKIKLS APVTLENLLP YDFKYRIYDK
ATKKDWTNFL RKGGVSPVHV VELSHLLLLS IDMQDTVFKA SDFSIINPGN NEEFRKEGRI
VVKDDQGLPL HLSLHYFKIP NSGGAFKVTV YSPYVVLNKT GVDVRVRAKS FLQQAKPAAG
QFPLMDTSNQ DHPKALPFMF SFGNDDHRNR ALLKIADSEW SKPQSFEAIG STTEVVLNSA
NKDKEIHVGV TVESGQGKYK LTKVVTLAPR FVLHNKIEGE ILVRESSSSG YLTLSDGALQ
PLHFMQKSKV KQLCLCYPGV NNQWTSPFNI ADIGTQYVKI AKAGQRQNLV KVEVLMENST
VFVNFSMETK TWPYSVRNES DIEFMFWQAN PNIDEEGVED RSGWRQIRYR LPPRSVMPYA
WDFPAAKFRE IIISANGKER HVKLAEIGNQ IPMKFVTASG NQKIVDINVA ADGPKQTLIL
SNFRASKSMY KPKALSRTNT GPEAFEVKDQ DTGATFRAQL KLAGIGVSLV NAQMKELAYL
TFRDVQLRYS DSPLIQTISM AIKWIQIDNQ LYGGIFPMIL YPTVVPKKAQ EVEAHPSLHF
MVSRVKDDSY GVLYVKYATI LLQEMSVELD EDFVFALLDF TNVPGASWTE VDEAGKLCDE
DLDIPEPSGL PAGTDIYFEV LNIQPMQLNL SFMRTERVNA EDKASSHNPI MFFLNVMTMA
VGNVNEAPLK FNALILDNVR VTTAVLIQNF SSHYSQEVMY QIHKILGSAD FLGNPVGLFN
SISSGVTDVF YEPYQGLILS DKPEEFGLGI AKGAASFAKK TVFGFSDSFS KFTGSLSKGL
AAASLDKQFQ DRRRITRARN KPKHALYGVT AGANSFITSV ASGVGGLARK PLEGAETEGA
LGFFKGVGKG FIGLATKPAV GVLDMASNVS EGIRNTTTVF DQDGLDRTRY PRYIPQDGIV
RPYNPREALG QYWLKQVDNG RYFDEQYIGH LELPKEDMVV MITYARILLI RSRRLTSEWD
VPLKDVQTIA KERTGVSLSL RGGANGPFIP IGEGSERGFL YKMIGVAVEE FNRRFRSGE
//
