ID A0A2T4H2K4_FUSCU Unreviewed; 842 AA.
AC A0A2T4H2K4;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Rho-GTPase-activating protein 8 {ECO:0000313|EMBL:PTD10034.1};
GN ORFNames=FCULG_00007878 {ECO:0000313|EMBL:PTD10034.1}, HYE67_006843
GN {ECO:0000313|EMBL:QPC64612.1};
OS Fusarium culmorum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=5516 {ECO:0000313|EMBL:PTD10034.1, ECO:0000313|Proteomes:UP000241587};
RN [1] {ECO:0000313|EMBL:PTD10034.1, ECO:0000313|Proteomes:UP000241587}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PV {ECO:0000313|EMBL:PTD10034.1,
RC ECO:0000313|Proteomes:UP000241587};
RA Schmidt R.;
RT "Fusarium culmorum secondary metabolites in fungal-bacterial-plant
RT interactions.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QPC64612.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Class2-1B {ECO:0000313|EMBL:QPC64612.1};
RA Yuan Z.;
RT "The chromosome-scale genome resource for two endophytic Fusarium species:
RT F. culmorum and F. pseudograminearum.";
RL Submitted (NOV-2020) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; PVEM01000003; PTD10034.1; -; Genomic_DNA.
DR EMBL; CP064749; QPC64612.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T4H2K4; -.
DR OMA; RKTWIYE; -.
DR Proteomes; UP000241587; Unassembled WGS sequence.
DR Proteomes; UP000663297; Chromosome 3.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04436; DEP_fRgd2; 1.
DR CDD; cd04399; RhoGAP_fRGD2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF17; RHO-GTPASE-ACTIVATING PROTEIN RGD2; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000241587};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2..434
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 215..292
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 468..666
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 162..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..737
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..803
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 842 AA; 94056 MW; E8D72E12AB738931 CRC64;
MPGFADSFWS SDYAAGLGVL FTKLQQGVHE NRQVLTIARL RAEAEETYGQ RLGDIAPAAD
KVAGGFSRDD GATVRKAFDG MRNEMQDAAR NHRRIAQSIR DLVVNPFSRW CDSHEARIQD
SQDELQVRIK AHDRQAEAVK KLRSVYFNKC RLVEDLEEEN KLAFQDPETS PKAGQNIPEI
KVQPHKEEEP EEEELYEIGD DTYQPEQVKK IISQMLSSIK MGETKVPILG TYLNTSSGSD
IVEYLQRSMG NINVAYAERI GQDLVNNGFL RLIGNVGSTF ANSSKMFYQW QSKAFTMAGV
PEKKSINRTF SLASTGSEGA ESPVGTVSEY LANWKVLNNS HPGETPSQRM QREAREADEK
YREGVRKLDE LRCELEEAIH LHLKFLERCE LDRLKAVKTV ILDFSGTIGN VIPSLQSTVD
QMMLFQETIQ PQNDLRYLVE TYRTGSFVPK VVVYENYYNK VDEQTFGIDL EARARADKKR
VPMIVTTLLT FLDHHYPDLE GDEARRGVWL LEVPLSQSHS LRAKVNDGKP VSPDVFDDFD
IPTIASLLKI YLLELPDSLV SSHVYEIIRT IYSTPSTDAD ESSRIAALQS TLSQLRLTNI
ATLDACMNHF TRLIDLTSAD ETYVASLASV LAPCILRPRT ETSLTMEEKH AYRLVRDLFA
HKDAIFSALK RMSMVTHSTS VGSNNRPRAI STDESNRKAL MEERNRALLE KASASRGRDK
SPAPGPRGHR RDRSTGGPET RFPIASPTAA SAVDRHRTSL GGVIKRQSLE VPEPDSAAPV
NGEAEKDKSD ADSDKRDSRD STGRTPTKFV GGKRVPVVPS TPSTPPSDSA RGVQLEDAPM
ED
//
