ID   A0A2T4H4U4_FUSCU        Unreviewed;       577 AA.
AC   A0A2T4H4U4;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Beta,beta-carotene 15,15'-dioxygenase {ECO:0000313|EMBL:PTD10829.1};
GN   ORFNames=FCULG_00011504 {ECO:0000313|EMBL:PTD10829.1}, HYE67_010464
GN   {ECO:0000313|EMBL:QPC68233.1};
OS   Fusarium culmorum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX   NCBI_TaxID=5516 {ECO:0000313|EMBL:PTD10829.1, ECO:0000313|Proteomes:UP000241587};
RN   [1] {ECO:0000313|EMBL:PTD10829.1, ECO:0000313|Proteomes:UP000241587}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PV {ECO:0000313|EMBL:PTD10829.1,
RC   ECO:0000313|Proteomes:UP000241587};
RA   Schmidt R.;
RT   "Fusarium culmorum secondary metabolites in fungal-bacterial-plant
RT   interactions.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:QPC68233.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Class2-1B {ECO:0000313|EMBL:QPC68233.1};
RA   Yuan Z.;
RT   "The chromosome-scale genome resource for two endophytic Fusarium species:
RT   F. culmorum and F. pseudograminearum.";
RL   Submitted (NOV-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|PIRSR:PIRSR604294-1};
CC       Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604294-1};
CC   -!- SIMILARITY: Belongs to the carotenoid oxygenase family.
CC       {ECO:0000256|ARBA:ARBA00006787}.
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DR   EMBL; PVEM01000002; PTD10829.1; -; Genomic_DNA.
DR   EMBL; CP064750; QPC68233.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2T4H4U4; -.
DR   OMA; WKSVRQE; -.
DR   Proteomes; UP000241587; Unassembled WGS sequence.
DR   Proteomes; UP000663297; Chromosome 4.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR   InterPro; IPR004294; Carotenoid_Oase.
DR   PANTHER; PTHR10543; BETA-CAROTENE DIOXYGENASE; 1.
DR   PANTHER; PTHR10543:SF24; CAROTENOID ISOMEROOXYGENASE; 1.
DR   Pfam; PF03055; RPE65; 1.
PE   3: Inferred from homology;
KW   Dioxygenase {ECO:0000313|EMBL:PTD10829.1};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR604294-1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR604294-1};
KW   Oxidoreductase {ECO:0000313|EMBL:PTD10829.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000241587}.
FT   BINDING         239
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT   BINDING         291
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT   BINDING         361
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT   BINDING         570
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
SQ   SEQUENCE   577 AA;  64157 MW;  0CACC7437CFC6476 CRC64;
     MALNGPGVYH RTREHEAEDA SSITKNFLAE SWRSWPNEAA FDRLEEHQGP LRLTLKGSIP
     SWAAGTLYRT GPGQSRVEDT ARGTHFTTHW FDGFAQTHRF DIVPSEDGET QVWYSSKRQS
     DEWVADVKKK GWRSGMTFGQ KADPCVGIFA KVMTIFEPKL GNHNVALLAN IPGVLDDEKE
     VDEKANGVTG PLGHRVNNLF VATDYSGMRR IDPSTLEPLG ETTQSHLHPS LSGPCSCAHA
     QRDPASGDLF NFNLAFGRVP TYRIFRVDAA SGETEILATI SDVNAPPAYM HSFFLSENYV
     ILCIPASQFA WRGLKTQWEG NIIDSMKPFE KNRDCKWLVV DRRHGKGLVA TFSTPAAFFF
     HSINAFEEKV KDEHGNKRTK LFVDLAKYDS MDIIKGFYYD VIMDRNDATK KYWFENERYK
     NCAPTLTRYS FTLPLVPTPD MSFASKGEQT LAILSPHTGE LPSIHPMRVG KPYRYVYSAA
     LRGMSTIVDS LVKTDLKTGD ALLWSGPRGH TPGEPVFVPR PGAEDEDDGV IFSLIVDGGA
     ETAYVVCLDG KTMGEMGRAE ADFAIGQGFH GIHIPAA
//