ID A0A2T4H7J5_FUSCU Unreviewed; 2072 AA.
AC A0A2T4H7J5;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Bikaverin polyketide synthase bik1 {ECO:0000313|EMBL:PTD11780.1};
GN ORFNames=FCULG_00005121 {ECO:0000313|EMBL:PTD11780.1};
OS Fusarium culmorum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=5516 {ECO:0000313|EMBL:PTD11780.1, ECO:0000313|Proteomes:UP000241587};
RN [1] {ECO:0000313|EMBL:PTD11780.1, ECO:0000313|Proteomes:UP000241587}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PV {ECO:0000313|EMBL:PTD11780.1,
RC ECO:0000313|Proteomes:UP000241587};
RA Schmidt R.;
RT "Fusarium culmorum secondary metabolites in fungal-bacterial-plant
RT interactions.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PTD11780.1}.
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DR EMBL; PVEM01000001; PTD11780.1; -; Genomic_DNA.
DR OMA; WKDSIWA; -.
DR Proteomes; UP000241587; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR030918; PT_fungal_PKS.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR04532; PT_fungal_PKS; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR Pfam; PF16073; SAT; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000241587};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 378..813
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1665..1743
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 355..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1624..1653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1746..1784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1746..1777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2072 AA; 225562 MW; CF4C98FCB3F8EF35 CRC64;
MTPSMMEVFV FGDQSTRFAP PLKDLLLKGN SPYLTHFVKQ VHALLRKEIS SLPAVQQKLF
PNFADIQELV SRSDWGSGNP ALTSALACFY HLCSFIYFYD GQGRTFPSEN SRIIGLCVGS
LAAAAVSCST SLSELVSAGV DAVRVALHVG LRVWRTTSLF DVPDRPSATW SIIVPEAVLP
RESAQDRLDS FIIEMGLARS SVPYISSVAH HNMTISGPPS VLEKFIHSIS SSPKDSLPVP
IYAPYHASHL YSMDDVDEVL SLSAPSFASE SIIPLISSSS GDELQPLKYA DLLRCCVSDM
LIQPLDLTKV SQAVAQLLEV SSSTRAILKP IATSVSSSLV SALEPTLAER CAVDNSMGPK
ASTSHSSTEQ QTESSSKNSK IAIVAMSGRF PDAADLGEFW DLLYEGRDVH RQIPEDRFNA
ELHYDATGRR KNTSKVMNGC FIKEPGLFDA RFFNMSPKEA EQSDPGQRMA LETAYEALEM
AGIVPDRTPS TQRDRVGVFY GMTSDDWREV NSGQNVDTYF IPGGNRAFTP GRLNYFFKFS
GPSASVDTAC SSSLAALHLA CNSLWRNDCD TAIAGGTNVM TNPDNFAGLD RGHFLSRTGN
CNTFDDGADG YCRADGVGTI ILKRLEDAEA DNDPILGVIL GAYTNHSAEA VSITRPHAGA
QEYIFSKLLR ESGTDPYNVS YIEMHGTGTQ AGDATEMTSV LKTFAPTSGL GGRLPHQNLH
LGSVKANVGH GESASGIIAL IKTLLMMEKS IIPPHCGIKT KINHHFPTDL AQRNVHIAKV
PTSWTRSGQA NPRIAFVNNF SAAGGNSAVL LLDAPQSSVA TDVVDPRSFH VVTMSARSAD
SLRKNLANLK ELVEGQGDSE VDFLSKLSYT TTARRMHHQF RASITAQTRE QLLKGLDSAI
ERQDVKRIPA AAPSVGFVFS GQGAQYRGMG KEYFTSFTVF RSEIMSYDSI AQAQGFPSIL
PLIRGEVEAD SLSPVEIQLG LTCLQMALAK LWKSFGVEPS FVLGHSLGHY AALHIAGVLS
ANDTIYLTGI RAQLLVDKCQ AGTHSMLAVR ASLLQIQQFL DANIHEVACV NGPREVVISG
RVADIDQLVG LLSADNIKAT RVKVPFAFHS AQVDPILSDL DTAASRVTFH SPQIPVLCAL
DSSVISPGNH GVIGPLHLQR HCRETVNFEG ALHAAEREKI INKTSTLWIE IGPHVVCSTF
LKSSLGPSTP TIASLRRNDD CWKVLADGLS SLYSSGLAID WNEYHRDFKA SHQVLRLPSY
SWEHKNYWIQ YKYDWSLTKG NPPVAPNSSV EAVSALSTPS VQKILQETSP DQVLTIVAET
DLASPLLSEV AQGHRVNGVK VCTSSVYADV GLTLGKYILD NYRTDLEGYA VDVHGIEVHK
PLLLKEDMNG TPQATPFRIE VRYPIQSTTA LMSIFTTGPN GQHIKHANCE LRLEHPSQWE
AEWDRQAYLI NRSVNYLLQR SAQGLDSMLA TGMVYKVFSS LVDYSDGYKG LQEVVLHSQE
LEGTAKVRFQ TSSGGFVCNP MWIDSCGQTT GFMMNCHQTT PNDYVYVNHG WKSMRLAKAF
REDGTYRTYI RMRPIDGTKF AGDLYILDED DTVVGVYGDI TFQGLPRRVL NTVLPSANAV
PLDAPMGRRD VPPSRMDVPP VRSGEGPPTS APTQQAIALP FAADTSMDSR LRPLLRILSE
EIGLGLDVLS DDELDFADHG VDSLLSLTIT GRMREELGLD VESTAFMNCP TLGSFKLFLG
LVDQDNKSSS GSDGSGRSSP TPGIESGATT PPMSEEDQDK IVSSHSLHQF QASSTLLQGS
PSKARSTLFL LPDGSGSATS YASLPPISPD GDVAVYGLNC PWLKDAGYLV EFGLKGLTEL
YVNEILRRKP QGPYNLGGWS AGGICAYEAA LILTRAGHQV DRLILIDSPN PVGLEKLPPR
LYDFLNSQNV FGSDNPHSTA GTSAKAPEWL LAHFLAFIDA LDAYVAVPWD SGLVGLASPL
PAPPQTYMLW AEDGVCKDSD SARPEYRDDD PREMRWLLEN RTNFGPNGWE ALLGGKEGLF
MDRIAEANHF SMLKRGRNAE YVSAFLARAL GD
//
