ID A0A2T4JJF2_9RHOB Unreviewed; 695 AA.
AC A0A2T4JJF2;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=DNA polymerase III subunit epsilon {ECO:0000313|EMBL:PTE18015.1};
GN ORFNames=C5F46_06455 {ECO:0000313|EMBL:PTE18015.1};
OS Phaeovulum veldkampii DSM 11550.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Phaeovulum.
OX NCBI_TaxID=1185920 {ECO:0000313|EMBL:PTE18015.1, ECO:0000313|Proteomes:UP000241899};
RN [1] {ECO:0000313|EMBL:PTE18015.1, ECO:0000313|Proteomes:UP000241899}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11550 {ECO:0000313|EMBL:PTE18015.1,
RC ECO:0000313|Proteomes:UP000241899};
RA Meyer T.E., Miller S., Lodha T., Gandham S., Chintalapati S.,
RA Chintalapati V.R.;
RT "Rhodobacter veldkampii.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC responsible for most of the replicative synthesis in bacteria. The
CC epsilon subunit contain the editing function and is a proofreading 3'-
CC 5' exonuclease. {ECO:0000256|ARBA:ARBA00025483}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PTE18015.1}.
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DR EMBL; PZKF01000011; PTE18015.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T4JJF2; -.
DR OrthoDB; 9804290at2; -.
DR Proteomes; UP000241899; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProt.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd06127; DEDDh; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006054; DnaQ.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR NCBIfam; TIGR00573; dnaq; 1.
DR PANTHER; PTHR30231; DNA POLYMERASE III SUBUNIT EPSILON; 1.
DR PANTHER; PTHR30231:SF4; PROTEIN NEN2; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000241899};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 500..670
FT /note="Exonuclease"
FT /evidence="ECO:0000259|SMART:SM00479"
SQ SEQUENCE 695 AA; 75534 MW; 976262B2E2CB37AD CRC64;
MIHRLSLRFR VFLFFVALAV GNCAALTVGL FLGYQRLGNP DDLNAFISGG VAAGFVILGL
ITWVWYLFDI NVAKPIERLA GGIRARTHAD VAAEMDHTPA RYLGDLAPAA MAATQHLSDA
RNALAEAVAR ETTRLAAEKE RLETLLSDVP VGVLLCSPDH QLVFYNGHAV GLLGSLDAPG
LDRRLFDYLH DAPILHAYAR LLETDDPDAA SDLLCASTAG SRVLAARMRL LTDLSACAGG
QARPGYVLTL RDVTADLAAH ATREALMDEL FDRLRRPAAN LQAMIGVLSE QQVGLTEPLD
RALRTEVTGL TQAINDLAHR HDAARADWWP LSMTRATDLT AAVQVLLAPE DIALHCHTSD
LILRCDGFEI VALLAALVTR AAPGRSDFRL EIAEDGAGAL ITLDWAGPPL PVSELDRWLA
APLQVGMADV TGRTVLSLHA TELWPEPRPH GRARLCLPLR EARLAHGRPA PIPRGVVYDF
DLLSKSRNAE VLNTRLEDLT YVVFDTETTG LLPSEGDEIV QIAAVRIVNG RRVGKEVFDT
LVNPRRTIPP ASTQVHGISD AMVVDAPGIE EVGRRFHKFA EGAVLVAHNA PFDMEFLRRH
ELGIGRVFDH PILDTVLLSA VIFGQSESHS LDALTHRLGI TIPEEARHTA IGDTVATADA
FLKLLPVLKA RGHVTFGDVL AEVRKHGRLL RDLNI
//
