ID A0A2T4K0W6_9RHOB Unreviewed; 875 AA.
AC A0A2T4K0W6;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=C5F48_00610 {ECO:0000313|EMBL:PTE23789.1};
OS Cereibacter changlensis JA139.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Cereibacter.
OX NCBI_TaxID=1188249 {ECO:0000313|EMBL:PTE23789.1, ECO:0000313|Proteomes:UP000241010};
RN [1] {ECO:0000313|EMBL:PTE23789.1, ECO:0000313|Proteomes:UP000241010}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JA139 {ECO:0000313|EMBL:PTE23789.1,
RC ECO:0000313|Proteomes:UP000241010};
RA Meyer T.E., Miller S., Lodha T., Gandham S., Chintalapati S.,
RA Chintalapati V.R.;
RT "Cereibacter changlensis.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PTE23789.1}.
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DR EMBL; PZKG01000001; PTE23789.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T4K0W6; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000241010; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000241010}.
FT DOMAIN 701..717
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 627..634
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 875 AA; 94584 MW; 8EA10B45C3792483 CRC64;
MSEETVTPMM AQYLEIKAQH QGAILFYRMG DFYEMFFDDA VAAAEALDIA LTKRGKHRGE
DIAMCGVPVH SSEGYLLALI RKGFRVAIAE QMEDPAEAKK RGSKSVVKRD VVRLVTPGTL
TEDSLLEARR HNFLCAFAEV RDEAALAWCD ISTGEMRVMG CSLTRLAPEL ARLAPREVLV
AEGRDLHALV EEAGAALTEM ARASFDSGSA EKRLCTLYGV GTLEAFGAFG RAEISAMGAL
VDYLDLTQRG KLPLLRPPIR EVVGGTMQID ASTRRNLEIT QALSGGREGS LLSAVDRTVT
APGARLLERR LSSPSRDLAV IGARLAAVRF LLEQGRLREE LRGDLRRVPD MDRALSRLAL
DRAGPRDIAA IRAGLAQAEA ISGRLPAEAP ALLDDARAAL RGHERLIDLL DQALVAEPPL
LARDGGFIAQ GFDEDLDETR RLRDEGRGVI ASMQAGFVEQ TGIASLKIKH NNVLGYFIEV
TSTHAERMLS APLSETFIHR QTTAGQVRFT TLPLSELETK ILNAGNRALE IEKAHFAALR
EAVLAEAGPV GAAARALAEV DLAAGLADLA AAEDWTEPRI DDSRAFEIEG GRHPVVERAL
ARTGTPFVAN DCALTDAMTP AIWLLTGPNM AGKSTFLRQN ALIALLAQAG SYVPAKRAHI
GLVSQLFSRV GASDDLARGR STFMVEMVET AAILNQADDR ALVILDEIGR GTATYDGLSI
AWATLEHLHD MNRCRALFAT HYHEMTGLSA KLTGVENATV SVKEWEGDVI FLHEVRKGAA
DRSYGVQVAR LAGLPASVIE RAKTVLNALE SGDREGGARK QALIDDLPLF RAAPPPPPVA
KAKASEVEAR LEGVLPDELT PMEALKLVYE MKALL
//
