ID A0A2T4U2C2_9BACI Unreviewed; 506 AA.
AC A0A2T4U2C2;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=Putative aldehyde dehydrogenase AldA {ECO:0000256|ARBA:ARBA00039869};
DE EC=1.2.1.3 {ECO:0000256|ARBA:ARBA00024226};
GN ORFNames=C6Y45_15895 {ECO:0000313|EMBL:PTL37550.1};
OS Alkalicoccus saliphilus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Alkalicoccus.
OX NCBI_TaxID=200989 {ECO:0000313|EMBL:PTL37550.1, ECO:0000313|Proteomes:UP000240509};
RN [1] {ECO:0000313|EMBL:PTL37550.1, ECO:0000313|Proteomes:UP000240509}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6AG {ECO:0000313|EMBL:PTL37550.1,
RC ECO:0000313|Proteomes:UP000240509};
RA Zhao B.;
RT "Alkalicoccus saliphilus sp. nov., isolated from a mineral pool.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00024149};
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|RuleBase:RU003345}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PTL37550.1}.
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DR EMBL; PZJJ01000044; PTL37550.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T4U2C2; -.
DR OrthoDB; 9762913at2; -.
DR Proteomes; UP000240509; Unassembled WGS sequence.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd07116; ALDH_ACDHII-AcoD; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR43111; ALDEHYDE DEHYDROGENASE B-RELATED; 1.
DR PANTHER; PTHR43111:SF1; ALDEHYDE DEHYDROGENASE B-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345}.
FT DOMAIN 32..493
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 262
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 506 AA; 56040 MW; E4DC45125A719384 CRC64;
MKYAVPNSEG SVVQFREKYD NYIGGKFQPP ANGEYFDNVT PVTGKAFTKI ARSSKEDIES
ALDAAHEAKA DWGMMSVTDR ANILNKIADR MEANLEKLAV AETWENGKAV RETLAADIPL
AIDHYRYFAS AIRTQEGGIS QIDKDTVAYH FHEPVGVVGQ IIPWNFPLLM AAWKIAPALA
GGNCIVLKPA EQTPSSIFVW LELIEDLLPP GVLNVVSGFG VEAGKPLASN PRIDKIAFTG
ETTTGRLIMQ YASENIIPVT LELGGKSPNL FFEDVMQQDD SYLDKAFEGF AMFALNQGEV
CTCPSRALIQ ESIYDKFMEK AVERVKKIKV GDPLDTETMM GAQASKEQFD KILSYLDIGK
QEGAKLLCGG ERAELEGHLS GGYYVQPTIF EGHNKMRIFQ EEIFGPVLSV TSFKDKEEAL
ETANDTLYGL GAGLWTRNVN TAYHFGRAIQ SGRVWTNCFH DYPAHAAFGG YKKSGIGREN
HLMMLSHYQQ TKNLLVSYSE EPKGFF
//
