ID A0A2T5G2J3_9SPHN Unreviewed; 876 AA.
AC A0A2T5G2J3;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=CLG96_04505 {ECO:0000313|EMBL:PTQ13364.1};
OS Sphingomonas oleivorans.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=1735121 {ECO:0000313|EMBL:PTQ13364.1, ECO:0000313|Proteomes:UP000244162};
RN [1] {ECO:0000313|EMBL:PTQ13364.1, ECO:0000313|Proteomes:UP000244162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FW-11 {ECO:0000313|EMBL:PTQ13364.1,
RC ECO:0000313|Proteomes:UP000244162};
RA Wang L., Chen L.;
RT "Sphingomonas panjinensis sp.nov., isolated from oil-contaminated soil.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PTQ13364.1}.
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DR EMBL; NWBU01000004; PTQ13364.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T5G2J3; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000244162; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 3.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000244162}.
FT DOMAIN 701..717
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 627..634
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 876 AA; 92152 MW; BB7B49D260008417 CRC64;
MAGTMKNGTA AAQTTPMMAQ YLALKAQCPD CLLFYRMGDF FELFLEDARI AAACLDIALT
ARGEHDGAAV PMCGVPAHSA ESYLARLIKA GHRVAIAEQT ETPAEAKKRG GSKALVGRAI
VRVVTAGTLT EETLLDARAA NWLVAIAEAG GALGLAAADI STGRFEIAAL VPGALDAELA
RLGAAEIIVP EGFSYDLPAA YPTPDGFDSI AAERRLKALF GVATLDGYGG FSRAELAAAG
GLLAYLDRAG QGTLPFLQPP RRRAASDHMM IDAATRESLE ITAAAGGGRK GSLLDAVDRT
VTGAGARLLA ADLGAPLTEI APIEARLDLV ALFAGDGGLR DMLRSKLRAL PDIGRALGRL
AAGRGGPRDL GLLRDGLDEG YGLHQILERI APRPMLLDAL LPRFIGHGAL VDILRRALVP
SPPIDASNGG YIAEGYDPAL DDLRGQGGEG RRAIAALEAR YRDETGIAAL KIRHNAVLGY
HIEVPARHAD RLLKADSGFT HRQTLAGVVR FNAPELHDHA MRVTQSGAHA LAAEAAHLEE
LTAATLARAA EIAATADALA RLDVAAGLAE RASEGGWCRP AFTDHPCFEV EGGRHPVVES
AVAASGDRFV ANDCRLSPDN RLWLVTGPNM GGKSTFLRQN AAIAILAQAG AFVPATKATM
GLVDRLFSRV GASDNLARGR STFMVEMVET AAILAQATEH SFVILDEVGR GTSTYDGLAI
AWAVVEAVHD LNRCRCLFAT HYHELTRLAE RLDALSLHHV RAREWKGDLV LLHELARGPA
DRSYGIAVAR LAGLPPPVLA RAGDVLKRLE AGRAATGGLA AGLDDLPLFA AAAAKPEEAP
DPLRTALDAI DADALSPRDA LDLIYRLKRL AAEGES
//
