ID A0A2T5H776_9PSED Unreviewed; 1047 AA.
AC A0A2T5H776;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN ORFNames=C8K61_11544 {ECO:0000313|EMBL:PTQ67426.1};
OS Pseudomonas sp. GV071.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=2135754 {ECO:0000313|EMBL:PTQ67426.1, ECO:0000313|Proteomes:UP000244119};
RN [1] {ECO:0000313|EMBL:PTQ67426.1, ECO:0000313|Proteomes:UP000244119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GV071 {ECO:0000313|EMBL:PTQ67426.1,
RC ECO:0000313|Proteomes:UP000244119};
RA Pelletier D.;
RT "Populus root and rhizosphere microbial communities from Tennessee, USA.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU364070}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU364070}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942,
CC ECO:0000256|RuleBase:RU364070}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU364070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PTQ67426.1}.
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DR EMBL; QAOJ01000015; PTQ67426.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T5H776; -.
DR Proteomes; UP000244119; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF78; CATION OR DRUG EFFLUX SYSTEM PROTEIN; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW Cell membrane {ECO:0000256|RuleBase:RU364070};
KW Membrane {ECO:0000256|RuleBase:RU364070};
KW Reference proteome {ECO:0000313|Proteomes:UP000244119};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364070};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364070}; Transport {ECO:0000256|RuleBase:RU364070}.
FT TRANSMEM 342..361
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 394..415
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 444..466
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 472..499
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 536..556
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 869..888
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 895..917
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 923..948
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 969..988
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 1000..1026
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
SQ SEQUENCE 1047 AA; 113674 MW; 975B34D4CE3D4CCA CRC64;
MISRFFIDRP IFATVISVVI VLAGLSAMRS LPISQYPEIL PPQVAVSANY PGASSQVIAE
TVAAPLEQEI NGVENMIYQL SNSDSSGAMS LNVYFQVGTD PDQATIDVNN KVQAALAKLP
EEVRRQGVKV EKKSSDILQV ITLYSPDGSR DPIFISNYAL INVIDELKRL KGVGDASQFG
SKDYSMRIWL RPDKLAQYNL TPTDVVSAIQ EQNSQFAAGS FGRQPLTKEQ DFTYTVTTQG
RFADPKEFES IILRSDTTGA SLLLKDVARV ELGAQDYSLM TSLNGQQNAA FGIYLQPGAN
ALDTAKAVSD TMERLAKRFP SGMTYKIPYD TTKFVKVSIE EVIHTFFEAL VLVVLVVFIF
LQNWRATLIP VLAIPVSLIG TFAGMYMLGF SINLLTLFGL VLAIGIVVDD AIVVLENVER
VMRTEKLPPR EAAIKAMEEV TGPIIAIVLV LCAVFIPVGF LGGLAGQMYK QFAITIAVSV
AVSGLVALTL SPALCALLLK PEHKEPAAPF RWFNTFFDKA TAGYSRGVVF FLKRSFIGLL
LFGGMIALMV VLFGRVPSSL VPDEDQGYVL NAYFLPSAAS LTRTEKVTSD VTEQLMKHPA
VQDVVTFAGF DVLTFGTRSN AGVSFIPLKD WSERTTEELD ARNLPRAFMG MGASQKDAMV
MTFNPPPITG MSTTGGFEAY IQDRSGGSSE QLEQMVHKFM AAAAKRPELA GVNTTFNAEV
PQYYIDLDRT KARALGVAIN DVFTAMQTTF GSYYVNDFNL YGRTWQVSLQ AEAEFRRKPE
DLSQVYVRSS VTSELVPLSS LVSVRRILGP DSYARFNVYP AAKVLGGPAP GYSSGQALEA
MQEVADETLG ADYTLGWIGQ AYQELASQGS GSTAFIFGLV MVFLILAAQY ERWTLPVAVV
TAVPFAVFGA ILAVWLRGIQ NDVYFQVGLV TLIGLAAKNA ILIVEFAVLC RQQGMSIYDS
ALEAAKLRFR PIVMTSLAFI LGCVPLAIST GAGSASRHSI GTGVIGGMLA ATLLATFVIP
MFYLLVETAS AKLSKKKPKQ ADSPDAH
//
