ID A0A2T5JBQ5_9SPHI Unreviewed; 974 AA.
AC A0A2T5JBQ5;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=C8P68_1029 {ECO:0000313|EMBL:PTQ99194.1};
OS Mucilaginibacter yixingensis.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Mucilaginibacter.
OX NCBI_TaxID=1295612 {ECO:0000313|EMBL:PTQ99194.1, ECO:0000313|Proteomes:UP000244168};
RN [1] {ECO:0000313|EMBL:PTQ99194.1, ECO:0000313|Proteomes:UP000244168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 26809 {ECO:0000313|EMBL:PTQ99194.1,
RC ECO:0000313|Proteomes:UP000244168};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PTQ99194.1}.
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DR EMBL; QAOQ01000002; PTQ99194.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T5JBQ5; -.
DR OrthoDB; 32195at2; -.
DR Proteomes; UP000244168; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:PTQ99194.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000244168};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 262..518
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 974 AA; 111728 MW; 5D8985CAB97F95B6 CRC64;
MVQNTDFRRY LTSLSYSEEE IAAGLLDETT FSYTVDTEGR LTVKYIFTPT ANDIYLEHRS
LWNMNRDNVF IAVTDQQSHI INVKEKPDAA RPLKNAICLR TFEYGVNSLG FEEIVPSEIS
KQYIDSAFFF DFVAKNQRKG QEVDKDLLLN LLQLKSDLIS DSNEEMIHLL ILRCIFIKYL
EDRGIFETDY LINILKSLDA KQLVAAFNEI KKINGDVFKY DSFKVTDIKQ EYLKQLALFF
ETDYRSGQHF LFPYQFDRIP IQLISHVYEA FLKDNSKKRK GIYYTPSFLV DFMLNQLFNG
EDNIPLADAR CLDAAVGSGA FLVECFKRIQ ASFGRPLSFD EKKKILETQL FGIDIDQKAL
QITAFSLYLA LLETEDPNFI KNEIIHAHPI LPSLIGSTLM SANAITDEVF KGQTFDYIIS
NPPWGSVPKV EDAQDEQEIN NILKERKAIA NKGKGDGIYA HVADFERSQA FLVRFQEWAG
ASTRIAAVVK NSIFLNDNAR DFRSYLLDTY ALEKFFELSH YNKILFKKKN IGEIKGQAVE
LGASEPCAVV ILKQLPANAS EISTTYISPK LSIFAENFSV IHFTARDCFQ IAQSNLKNQD
AYWKILVNGD LDTFKVIEKL SLQCDLTVEA RAGFQPKANM LSLGEPDWKP IAEPTDFKQF
DVLKADNLPV FNWNQGLHRR REFDIFQGIR LVIPVRPLKS DKFLFRGAIA YDDIIYKHNM
ITIKLKDGKD YISDYLPYLA IINSKLIGFL FYQLSIQWGK GEGKRDSIRN VDLEKLPLKR
ISDPTLAKQL SNLVSKIQIA IRGGQNPIIE IDELDELVFE HYGLLDYERQ VIKEFYQMNV
DRADAPLNKV TASDLNVYFN AFVKAFQLVL AEGTVLSATY NISGNMGALI CMRLSQQNEA
EPFRQGEDKH IINFVKSGQL NKAEALKILE EEKVKIYDKE HIYLIKSNQF KDWTPRQAVV
DAREEIQQYI KHLA
//
