ID A0A2T5LLQ8_9EURO Unreviewed; 1869 AA.
AC A0A2T5LLQ8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Sorting nexin MVP1 {ECO:0000256|ARBA:ARBA00014268};
GN ORFNames=P175DRAFT_0446426 {ECO:0000313|EMBL:PTU17212.1};
OS Aspergillus ochraceoroseus IBT 24754.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=1392256 {ECO:0000313|EMBL:PTU17212.1, ECO:0000313|Proteomes:UP000244073};
RN [1] {ECO:0000313|EMBL:PTU17212.1, ECO:0000313|Proteomes:UP000244073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 24754 {ECO:0000313|EMBL:PTU17212.1,
RC ECO:0000313|Proteomes:UP000244073};
RX PubMed=29317534; DOI=10.1073/pnas.1715954115;
RA Kaerboelling I., Vesth T.C., Frisvad J.C., Nybo J.L., Theobald S., Kuo A.,
RA Bowyer P., Matsuda Y., Mondo S., Lyhne E.K., Kogle M.E., Clum A.,
RA Lipzen A., Salamov A., Ngan C.Y., Daum C., Chiniquy J., Barry K.,
RA LaButti K., Haridas S., Simmons B.A., Magnuson J.K., Mortensen U.H.,
RA Larsen T.O., Grigoriev I.V., Baker S.E., Andersen M.R.;
RT "Linking secondary metabolites to gene clusters through genome sequencing
RT of six diverse Aspergillus species.";
RL Proc. Natl. Acad. Sci. U.S.A. 115:E753-E761(2018).
CC -!- FUNCTION: Required for vacuolar protein sorting.
CC {ECO:0000256|ARBA:ARBA00002474}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PTU17212.1}.
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DR EMBL; MSFN02000011; PTU17212.1; -; Genomic_DNA.
DR VEuPathDB; FungiDB:P175DRAFT_0446426; -.
DR OrthoDB; 45524at2759; -.
DR Proteomes; UP000244073; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd07597; BAR_SNX8; 1.
DR CDD; cd06866; PX_SNX8_Mvp1p_like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028662; SNX8/Mvp1.
DR InterPro; IPR035704; SNX8/Mvp1_PX.
DR InterPro; IPR045734; Snx8_BAR_dom.
DR PANTHER; PTHR47554; SORTING NEXIN MVP1; 1.
DR PANTHER; PTHR47554:SF1; SORTING NEXIN MVP1; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF19566; Snx8_BAR_dom; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1496..1611
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 26..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1305..1491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..67
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..213
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..610
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1321..1339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1396..1440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1869 AA; 207364 MW; 18FF274BF31DCC53 CRC64;
MAMGQGEQRA IHPFFRKGYE QATNSHDALN NVHVGSPASH ASPPVAMLDP DPNADRRKRR
KTSNEPSALA EDETLSPYDS APPTNAMNPS GDKHPSPQPS ANHTNSTPSS SVPDSNTPTK
RIILKLNPNG KLLSSPVADK LSDRSKKAKG NKRGKQGQKK VVVIKYSNKG VSEILGKKID
DIINGRAKFT PTSLPAIPTP PESSAPKKTQ PPKPTHPFFL KKAIRKSEIS PPHSPSHDST
PTESEREELW KFAPSRPPSS FFSKAPVSFR QSLKFPEPIY PIWPPRGLTH VRDISDINMQ
DEDLPCPVEI DHRKSKMAAI QIHDSENVLS LIVNDAGESR PLLRIPQRQV TSGLALQTIM
AEQLSGLFSK SSTNEPGTNY HPAIVKLNSS LLSSMTAFDR GEFDTHTWAQ KYAPNAAPQV
LCATKEAFML RDWLKNLMVL AVDTGKPSKE NEKTKRKAEE KKRKRRKKSD KLDGFIVSSE
DEASEMDEVN GSDDELAGDV TVSNKRTVVR SGDLTFHLKS GGDRGRMSNA ILLSGPSGCG
KTASVYAVAK ELDFEVFEIN AGSRRSAKDI VDRIGDMAQN HLVHGANCEE PTSNQPLLAN
SQSDPLEDSN QSKLMGFFKA PTAGPPKTSN ERSEPDTKKT YTKRARSQRQ SLILLEEVDL
LFEEDKQFWS GVLTLINQSK RPIVITCNDE SLLPLDDISF HAILRYRAPP PNLAVDYLLL
VAANEGHVLK RKAVEKLYRI TGHDLRRSIM ELNFWCQMAV GSEKSGLDWM MDRWPRGTDL
DANGDPLRVL SIDTYQEFMG WFSRDMLVGS KPLASDLELQ REAFHWWQLS FQESESMEDS
HNHSWSNPDP NASKLKLFDH LCEQSDFMAM RSAFDVLTAG CSPEPRTDAI DFSIPFLSEK
QNPNYIEGYQ LLNADHMPDY TALPIEIGSA CEAFIGKAFR QERDPDVEAK QARKVLEAVP
KPRTITSPGM ELFEALGPVI KPDYALSPNG RAEPSFEYTL RSVAEDLVPY VRSIITFDLR
LEQYRLELSG LLSGGSKGPK RIRTTRASRA ALEGGSKAET RKERWFTPNV NPSRILATGM
KEWQELLVQN GYFAMPSTGQ TREESEPVVL LSPLCLELTA PPHRQPPPLA STITVPRSSF
MSLFGTSPDD SSAADSAQRS KSSLFADEPS FGAASANFGS SSLFADDDGL DTGSPWNSNT
GKRTSKQQLV RTLLPDTDVP ENYIDAFDLV LSLDDRVGTG ISLTAVREIL SGGGISATDQ
AKILNLVISG EIDRSNGLGR GEFSVLLALM GLAQEGEDLT FDTVDDRRKT LPPPKSSYLD
SLRAKQDSTM STLSHERPTT PPPSSHPLPE PSSVQSRRSG RDSMGGLESD PWGSPQLHRG
HAHAQTEHEH GALNGYGSVR STTNAWSSGK STDGGNPSEP SNLSRPNGRS DVTPSSAGSG
FGWGDSFGHT SDGGGLGGPV RAGLGGDFSQ PGSDPNESNP RRRSLGLGRV TTPPVNEMVT
VTLLQEKEGM FMFQHRNYEV KSARRCSTVV RRYSDFVWLL DCLHKRYPFR QLPLLPPKRI
SVNGTHLAAD STSFLEKRRR GLVRFTNALV QHPVLSQEQL VVMFLTVPTE LSVWRKQATI
SVQDEFMGRV LPPDLEDSLP STLSDTFDTV RTGVKRSAEV YINLCTLLER LAKRNEGLAA
DHLRFSLALQ SLTEMTRDTY AIDRNDVPLL NDGIQATARH LSASQTLLED EARAWENGVL
EDLKRQRDCL VSVREMFDRR DRYARNNIPQ LERRIESNER KLQDLRTKPP ATVKAGEIEK
VEESIFKQHA RGVFIQECLR DELVYFQQSQ YHISRLHQDW SQERVKYSEL QADNWRSLSD
QVEGMPLGE
//
