ID A0A2T5LSQ2_9EURO Unreviewed; 1318 AA.
AC A0A2T5LSQ2;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 13-SEP-2023, entry version 17.
DE RecName: Full=REM-1 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=P175DRAFT_0502837 {ECO:0000313|EMBL:PTU19310.1};
OS Aspergillus ochraceoroseus IBT 24754.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=1392256 {ECO:0000313|EMBL:PTU19310.1, ECO:0000313|Proteomes:UP000244073};
RN [1] {ECO:0000313|EMBL:PTU19310.1, ECO:0000313|Proteomes:UP000244073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 24754 {ECO:0000313|EMBL:PTU19310.1,
RC ECO:0000313|Proteomes:UP000244073};
RX PubMed=29317534; DOI=10.1073/pnas.1715954115;
RA Kaerboelling I., Vesth T.C., Frisvad J.C., Nybo J.L., Theobald S., Kuo A.,
RA Bowyer P., Matsuda Y., Mondo S., Lyhne E.K., Kogle M.E., Clum A.,
RA Lipzen A., Salamov A., Ngan C.Y., Daum C., Chiniquy J., Barry K.,
RA LaButti K., Haridas S., Simmons B.A., Magnuson J.K., Mortensen U.H.,
RA Larsen T.O., Grigoriev I.V., Baker S.E., Andersen M.R.;
RT "Linking secondary metabolites to gene clusters through genome sequencing
RT of six diverse Aspergillus species.";
RL Proc. Natl. Acad. Sci. U.S.A. 115:E753-E761(2018).
CC -!- SIMILARITY: Belongs to the RICTOR family.
CC {ECO:0000256|ARBA:ARBA00008878}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PTU19310.1}.
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DR EMBL; MSFN02000006; PTU19310.1; -; Genomic_DNA.
DR VEuPathDB; FungiDB:P175DRAFT_0502837; -.
DR OrthoDB; 90320at2759; -.
DR Proteomes; UP000244073; Unassembled WGS sequence.
DR GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR Gene3D; 1.10.287.160; HR1 repeat; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011072; HR1_rho-bd.
DR InterPro; IPR036274; HR1_rpt_sf.
DR InterPro; IPR028268; Pianissimo_fam.
DR InterPro; IPR028267; Pianissimo_N.
DR InterPro; IPR029453; Rictor_IV.
DR InterPro; IPR029451; RICTOR_M.
DR InterPro; IPR029452; RICTOR_V.
DR PANTHER; PTHR13298; CYTOSOLIC REGULATOR PIANISSIMO; 1.
DR PANTHER; PTHR13298:SF11; RAPAMYCIN-INSENSITIVE COMPANION OF MTOR; 1.
DR Pfam; PF02185; HR1; 1.
DR Pfam; PF14663; RasGEF_N_2; 1.
DR Pfam; PF14666; RICTOR_M; 1.
DR Pfam; PF14664; RICTOR_N; 1.
DR Pfam; PF14668; RICTOR_V; 1.
DR SMART; SM00742; Hr1; 1.
DR SMART; SM01303; RasGEF_N_2; 1.
DR SMART; SM01307; RICTOR_M; 1.
DR SMART; SM01308; RICTOR_N; 1.
DR SMART; SM01310; RICTOR_V; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF46585; HR1 repeat; 1.
PE 3: Inferred from homology;
FT DOMAIN 121..190
FT /note="REM-1"
FT /evidence="ECO:0000259|SMART:SM00742"
FT DOMAIN 253..617
FT /note="Rapamycin-insensitive companion of mTOR N-terminal"
FT /evidence="ECO:0000259|SMART:SM01308"
FT DOMAIN 696..920
FT /note="Rapamycin-insensitive companion of mTOR middle"
FT /evidence="ECO:0000259|SMART:SM01307"
FT DOMAIN 1103..1174
FT /note="Rapamycin-insensitive companion of mTOR"
FT /evidence="ECO:0000259|SMART:SM01310"
FT REGION 20..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 148..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1318 AA; 146782 MW; 5C7A158542B49251 CRC64;
MASGYNSVFS ATSIQHRTLA DGRSLSSQDD VPMDGSWPGP AAASRTTVRN ARSESGGSTT
IGPRGGSLTP SLGGPGSFSS ELKSMKSSRS TTPRPDPRPD GPYARRPSST FDHDELSGTE
ERQAAIRDKI AKEMKIKSGT ENMLEALLAK NPKQTKDQRL RVESELSSSN RKLAELHHEL
EEELLRAQAP STPPRSRLSS LFQGSAMRSP SRHNVSDGEQ LEDGEAEMES PTYVLAETLQ
ALEIEGMSPD YYVERANSLV ELFKRHPTLK YDLAWSVFGL RVQVMLLSDS KEVVAAGYRL
TRYAIADRKS LRIIRSLHTD ELVILSLVKE SKANIEREQA LKFVRAFLDV KDGVKEISRA
VVRTVVSVAE HHEDRLQNIS LMTLAEILVK DPQLIAYAGG LAPLHDALAE GTFGASESLI
ASFLHVLDTP HSRTHLRGGS ELEAVLAPFT DSLSDTVRNG RLKSSAKAIS AMLKTWPGLV
ILGRNGARPL QSLLDSLHYP DPQARDLIME LLFDALRIKP PSWSSSFLAG RRLTTYGRVT
NLRSESETKQ IRGLCDNSEN KFDLTAHFST LILATLIDAG LSKALCDLIE EETDLSLRRK
ATLLLTEVLK LAHHSLPQRI SAKLQVLPHL ISPAIHFDVE NHDVSTSTIY QIESINRTLA
RSFGFPNGAA RYSADVDISA SLLSGDQNKD KLSPAMDETQ FRNAILETHV LNTVNYIKWK
WDLIHRIVEG PLTNPKRLDE AIKGSKFMKR LMGFYRPFKY RFAMLSNTKP NQRYVRTGCA
LMRTLVQTPE GIKYLAENKF LRQVAECLAQ VDRMSGLTSS SPVFSRDRMS TTLSGGYFAM
LGTLSADAKG LAMMERWHML NMFYHIIELR DRDDLIQTLL GNMDYTQGSH LRVLLSKALT
TGSKEIRIFG TRLLRKYAVG NVPLSSHMAV GNADWVIKLL VTQLYDPDVS VCQVAVKILE
EACNQRDYLE FVVRCRPSLD HLGEIGAPLL LRFLSTSVGY HYLDGLDYIT QEMDDWFLGR
NDAYVSLVEA ALSRAYVDQP RRNSLVPEDL VDLQDIGLVP PHFYRELART AEGCKLLEQS
GHFEEFAGTI RDLRLNEEDH EVLLKVKGCL WAVGNVGSME LGAPFLGLDI IKNIVKIAES
AEVLTMRGTA FFVLGLISRS RHGLQVLRQA GWDSALDQKG NSLGLCLPTN FGKLFLVDFP
TSSRPLEAKR TSQEKFKAAS MDPDPANQKI LKLIVDMGNT VLSKRAAADL HNIKSKQPER
FHQPHLFRKT LSILESHHFR LPARRFALDL FDKSVLRRIV IDDDSDSDLD ATSSEGSG
//
