ID A0A2T6DBC7_9BACT Unreviewed; 666 AA.
AC A0A2T6DBC7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Squalene--hopene cyclase {ECO:0000313|EMBL:PTX99734.1};
GN Name=shc {ECO:0000313|EMBL:PTX99734.1};
GN ORFNames=DB346_18110 {ECO:0000313|EMBL:PTX99734.1};
OS Verrucomicrobia bacterium LW23.
OC Bacteria; Verrucomicrobiota.
OX NCBI_TaxID=2161867 {ECO:0000313|EMBL:PTX99734.1, ECO:0000313|Proteomes:UP000244158};
RN [1] {ECO:0000313|EMBL:PTX99734.1, ECO:0000313|Proteomes:UP000244158}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LW23 {ECO:0000313|EMBL:PTX99734.1,
RC ECO:0000313|Proteomes:UP000244158};
RA Buenger W., Mueller J., Hurek T., Reinhold-Hurek B.;
RT "Genomic and phenotypic characterization of four novel plant-associated
RT Verrucomicrobia indicate a new subdivision with one cultivated member.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004999}.
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PTX99734.1}.
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DR EMBL; QAZA01000045; PTX99734.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T6DBC7; -.
DR OrthoDB; 9758578at2; -.
DR UniPathway; UPA00337; -.
DR Proteomes; UP000244158; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR006400; Hopene-cyclase.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01507; hopene_cyclase; 1.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000244158};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 37..326
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 339..657
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 666 AA; 75659 MW; 200F32A1B54134D9 CRC64;
MSAGAQPSPK TIAVPKQAFR VALAPAEVTA PELDAAISRT HDYLLGLQKP DGHWVGELIV
DSTLCADYIL FMHWWGAVNF TKQAKCVKHL LDRQLADGGW NIYVGGPSEL NATVKAYFAL
KLAGFHADDT LMRKAHSTIL RLGGIPRTMT YTRLLLSLFG QFPWRHLPII PSEMILLPNW
LYINIYDFSA WSRTMLIPLA VINHCRPVRH VPAEAQLHEL YPYGTEHDNF SPRWDKKVLT
WRNFFLRWDA ALKFVDTLPW KPFRSLALQK CEEWLVERID SRSDGLGAIF PAMMYTCIAL
KALGYSDDHP VLRKTLKDFD DLHVDDVAND DFRIQPCFSP IWDTAITSVV LTESGMSGDH
PALKKAADYI LSKEVRKTRG DWAINNPYPI NSGWAFEYNN EFYPDVDDTF KVLLALGNIK
TDDEENKKIV MERALKWAIS FQCQNGGFAA FDKDVTKKWL DEVPFADHNA ILDPPCSDIT
SRGLEVFGRM GMKRTDPVVQ RAIKFIRDTQ LSDGSWLGRW GINYIYGTFL VLRGLQAIGE
DMNQDWILRG RDWLESCQNE DGGWGESAAS YDDPRLKGQG PTTPSQTGWS LIGILACGNI
HRPSVQRGIH NLLSTQLPDG SWKEDYITGT GFPKVFYLKY DMYRINWPLL ALGEYRRQAD
QLALSQ
//
