ID   A0A2T6DFB4_9BACT        Unreviewed;       968 AA.
AC   A0A2T6DFB4;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Peptidase M16 {ECO:0000313|EMBL:PTY01088.1};
GN   ORFNames=DB354_00710 {ECO:0000313|EMBL:PTY01088.1};
OS   Opitutus sp. ER46.
OC   Bacteria; Verrucomicrobiota; Opitutae; Opitutales; Opitutaceae; Opitutus.
OX   NCBI_TaxID=2161864 {ECO:0000313|EMBL:PTY01088.1, ECO:0000313|Proteomes:UP000244023};
RN   [1] {ECO:0000313|EMBL:PTY01088.1, ECO:0000313|Proteomes:UP000244023}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ER46 {ECO:0000313|EMBL:PTY01088.1,
RC   ECO:0000313|Proteomes:UP000244023};
RA   Buenger W., Mueller J., Hurek T., Reinhold-Hurek B.;
RT   "Genomic and phenotypic characterization of four novel plant-associated
RT   Verrucomicrobia indicate a new subdivision with one cultivated member.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PTY01088.1}.
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DR   EMBL; QAYX01000012; PTY01088.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2T6DFB4; -.
DR   InParanoid; A0A2T6DFB4; -.
DR   OrthoDB; 9811314at2; -.
DR   Proteomes; UP000244023; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000244023};
KW   Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..968
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015588957"
FT   DOMAIN          48..168
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          210..392
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          705..865
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   REGION          934..968
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   968 AA;  106133 MW;  F2D3E5DB158FC4A4 CRC64;
     MRRLALLLPF LAFVTFAQAA LPFPQAASDL KPDPAAHFGT LPNGLRYVIR PNHEPRNRAS
     MRLLIKAGAL NENENQRGVA HFLEHLSFNG SEHYAPGTLI EFFQRMGMNF GDDTNASTGF
     DRTIYMLELP DTKPATLAEG FRVFSDYAGG LLLLADEIDK ERGIILSEKR TRDSVGYRTI
     VAQLGFLLDG SRFPQRWPIG EVEVITKAGR NEFLDFYNTW YRPDLMSVVV VGDVDVAAVE
     KLITETFSPL KLRAEARPAP DLGKLTLADQ SGVHVFHHPE AEAPETSVSI GTIQRYAAEP
     DTAAVRLKYL PRTLANYMIN RRLSILAKKE GAPFTSGSTS VSEEFDFFRE SAMTLTCRAD
     QWADALAVAD QELRRALEHG FQPAELKEVV ANFRNSLEQA VKTAPTRRSD SLAAELTSSL
     VDDEVFTTPA DDQALYGPAL ERVTPAECLA ALRAAWSAPH RLVMVTGNAR IEGDASAAIR
     AAFEKSAATK VAPPEVLADA KWGYTDFGPA GKVAQREHID DLDVTLVTFA NGVRLNLKKT
     DFEANRIRLN VRIGNGQLTE PADKPGLAGY ANQTFVEGGL GKHSVDELRR ILAGRTVGAS
     FGVAGDAFVS SGNTNQQDLL LQLQLMAARI VDPGFRPEAA RQARKAIEEL YLSLEHTPRG
     PFTLEVSRIL ASGDTRFGLP PREEMLKRNL NEVKAWVTPE LAHGYTEIAI VGDLDVEATI
     AAVAQTFGAL PPREPRAALE DRRKVKYPDE PFARSYSVPT EIPKGVVAIY WPTTDGLEIH
     RTRRLSLLGL VLSDRLRVKV REELGDAYSP GAGNNPSDIY PGYGYMTANV TIDPPRAQLI
     ADTVIAVGAD LFTKGTTDDE LARAKLPVLT QLRESARTNQ YWLGSVLARA QERPQQLDWC
     RTRYSDIESI TKSDIDALAK TYLAPEHASR VIVVPHRQPD EPAPAATATA PKPDAAKPAA
     QPGAPKPE
//