ID A0A2T6DTQ6_9BACT Unreviewed; 895 AA.
AC A0A2T6DTQ6;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=DB347_15840 {ECO:0000313|EMBL:PTY05822.1};
OS Opitutaceae bacterium EW11.
OC Bacteria; Verrucomicrobiota; Opitutae; Opitutales; Opitutaceae.
OX NCBI_TaxID=2161865 {ECO:0000313|EMBL:PTY05822.1, ECO:0000313|Proteomes:UP000244239};
RN [1] {ECO:0000313|EMBL:PTY05822.1, ECO:0000313|Proteomes:UP000244239}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EW11 {ECO:0000313|EMBL:PTY05822.1,
RC ECO:0000313|Proteomes:UP000244239};
RA Buenger W., Mueller J., Hurek T., Reinhold-Hurek B.;
RT "Genomic and phenotypic characterization of four novel plant-associated
RT Verrucomicrobia indicate a new subdivision with one cultivated member.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PTY05822.1}.
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DR EMBL; QAYY01000011; PTY05822.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T6DTQ6; -.
DR OrthoDB; 9784397at2; -.
DR Proteomes; UP000244239; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 2.
DR CDD; cd00156; REC; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 3.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR43065:SF10; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3; 1.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00086; PAC; 2.
DR SMART; SM00091; PAS; 3.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 3.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 2.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000244239}.
FT DOMAIN 164..196
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 215..267
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 397..470
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 541..754
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 774..894
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 828
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 895 AA; 97146 MW; 88F9ACEBDB946F8C CRC64;
MMQYVKQTPS RSSASVPASG QPSGAPVLLT LDAEGHVVDV SRSAEVYWTP AKSLIGVPVV
SLFSFGPESV HSGPSAAQWE LLRATAVGRP FSCSIRTNPP AIAPKVVVRL EESGLDDARY
FAQIESAETP ASNVSPMVVD SGLALLSNEG PVGFFDLNFK AGQVYYSPAW KRMLGYNDTE
LANTYDSWLR LLHPEDSAAA PDHTGKRAPR SARSFAVEVR MLHRHGNYIW VHCLGTQVYG
SMGELERVTG LQIDITERKE LEEQTLANEE RMQRLVESGD VGLFDLNFAS QQYWFSPHWR
KLIGSTALEG AQALKDFVEA LPSGRAMRGA ESFFVEPNVG HPSFITELRL IHADGSSVSV
LFGAHRQLSR KGELVRAVGF ACALPDALPK SAALPFGPAL LQTTLDSLGE GIVVADAQGI
VTHLNARAER LIGLERRDAR GRNLEQVFRL VYRDSRSVVE DPFETALSNS EEGRLFSDHA
LVSVADASLR NIVWSARRVA DAGAELGGIV IIFRDPEEMS LSPDELLKIN RFENLGIVAG
GISHDFNNLL TTILGGISQA KDSKDYSYLA DSERACLAAK ALTKQLLAVA RGGKSEVVQT
IPVQEVVRDA VRLARAGTNA EFRIEIPDSI HPIQVDRAQI LQVFQNLIIN SLQALPPRGG
SLWLSGVNVA LEEGNASGLS AGSYVRIEVR DNGCGIAPEN LELIFEPFFT TKKSGTGLGL
SMVRSIVRKF GGDVSVTSTL GAGTTFQVLL PRAATAADAA NKRVAPSLRF GTGRVLLMDD
DPDICHLAEG MLASLDYKYD IARNGEEAIT LYRRHLNIGR PYDAVILDLT IVGGAGGEET
FHKLREMDKD VRAIVCSGYD SEDMIRHYTD MGFSGYLSKP FRAADLGKTL KSVIG
//
