ID A0A2T6FIL2_9GAMM Unreviewed; 519 AA.
AC A0A2T6FIL2;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:PUA28199.1};
GN ORFNames=B0W54_17120 {ECO:0000313|EMBL:PUA28199.1};
OS Cellvibrio sp. 79.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC Cellvibrionaceae; Cellvibrio.
OX NCBI_TaxID=1954207 {ECO:0000313|EMBL:PUA28199.1, ECO:0000313|Proteomes:UP000243979};
RN [1] {ECO:0000313|EMBL:PUA28199.1, ECO:0000313|Proteomes:UP000243979}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=79 {ECO:0000313|EMBL:PUA28199.1};
RA Zhang Y., Xu J., Wang N.;
RT "Cellvibrio sp. 79 recovered from metagenome.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PUA28199.1}.
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DR EMBL; MVDH01000003; PUA28199.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T6FIL2; -.
DR Proteomes; UP000243979; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000243979}.
FT ACT_SITE 82
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 13..16
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 82
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 187
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 352
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 519 AA; 58144 MW; 37658EFF05F636E1 CRC64;
MNNPIKKIMI VGGGSAGWLT AGLIAAEHLV DKMRGIELVL IESPDVPIIG VGEGTWPSMR
TTLKKIGVSE TDFFRECDAS FKQGSKFIDW VKPGGGAYYH PFNLPDGGNE FNLAEQWLPF
RDTVTFADAV CPISHISERN LAPKLITTPE FVGNSNYGYH LDAGKFSVFL KQHCIEKLGV
TYIQDHVVKI NSAENGDIAS LSTKMNGDLS ADLFIDCTGF ASLLLGEHYQ IPLKQEHRVL
FNDSALAVQI PYPDADAPIA SCTLSTAQDC GWIWDIGLPT RRGVGHVFSS AHTSDEQVLK
NLQAYLEPAI GKAAAEKMMP RKLTFNPGYR QELWHKNCVG VGISAGFIEP LEATALVLIE
LSAQMIAEQL PATRGVMDTV AKRFNRKLFD HWQRIIEFLK LHYVISERRD TDYWRDHLDE
STQPDGLREL LELWRHHVPW RNDIRSDEMF PWASYQYILY GMGFQTNVPA VAKRGAAMNA
ENAGRMFSEN SKKTNALVKN LPTNRALLVK LREYGFQKI
//