ID   A0A2T7A195_TUBBO        Unreviewed;       518 AA.
AC   A0A2T7A195;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   22-FEB-2023, entry version 11.
DE   SubName: Full=Telomere-length maintenance and DNA damage repair-domain-containing protein {ECO:0000313|EMBL:PUU81506.1};
GN   ORFNames=B9Z19DRAFT_606068 {ECO:0000313|EMBL:PUU81506.1};
OS   Tuber borchii (White truffle).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC   Pezizales; Tuberaceae; Tuber.
OX   NCBI_TaxID=42251 {ECO:0000313|EMBL:PUU81506.1, ECO:0000313|Proteomes:UP000244722};
RN   [1] {ECO:0000313|EMBL:PUU81506.1, ECO:0000313|Proteomes:UP000244722}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tbo3840 {ECO:0000313|EMBL:PUU81506.1,
RC   ECO:0000313|Proteomes:UP000244722};
RG   DOE Joint Genome Institute;
RA   Murat C., Kuo A., Barry K.W., Clum A., Dockter R.B., Fauchery L., Iotti M.,
RA   Kohler A., Labutti K., Lindquist E.A., Lipzen A., Ohm R.A., Wang M.,
RA   Grigoriev I.V., Zambonelli A., Martin F.M.;
RT   "Draft genome sequence of Tuber borchii Vittad., a whitish edible
RT   truffle.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Serine/threonine protein kinase which activates checkpoint
CC       signaling upon genotoxic stresses such as ionizing radiation (IR),
CC       ultraviolet light (UV), or DNA replication stalling, thereby acting as
CC       a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-
CC       Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of
CC       DNA damage, involved in the regulation of DNA damage response
CC       mechanism. Required for the control of telomere length and genome
CC       stability. {ECO:0000256|ARBA:ARBA00025079}.
CC   -!- SUBUNIT: Associates with DNA double-strand breaks.
CC       {ECO:0000256|ARBA:ARBA00011370}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PUU81506.1}.
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DR   EMBL; NESQ01000044; PUU81506.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2T7A195; -.
DR   STRING; 42251.A0A2T7A195; -.
DR   Proteomes; UP000244722; Unassembled WGS sequence.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR021668; TAN.
DR   Pfam; PF11640; TAN; 1.
DR   SMART; SM01342; TAN; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000244722}.
FT   DOMAIN          32..162
FT                   /note="Telomere-length maintenance and DNA damage repair"
FT                   /evidence="ECO:0000259|SMART:SM01342"
FT   REGION          200..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        200..219
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   518 AA;  58004 MW;  2F724B099C27B16C CRC64;
     MPTKRYSRTR LRIDQMGFPV CGFSFALRVV LMFSNLDLKL ILGNSKHTRG LNDKGYHKMF
     EAIFRAVVKE KMMYARQNKP SLAKSVGTRL SLCASVFRLA VEQGVVHIRN KTFKALSKHV
     IDILPQGDGL CEPISLDYIK ALRTCLACSP HAEHIDKKEW ATLARFCCTH VESQLGLLIG
     DSESADEDTS VASRNVRLSL SRDTSSASRR SQPPSQGIPK LNHDSEELVL CLEILLKTPN
     APIIEHDEMV VKTILGFLVS QPAVTRAHLP AFTALNTILE VITTNNISLT AKVAQGIVPV
     LAKLWDSKQP TFREQMMITL IHILPQVRTI ISEGQSRVLR RKVEALSEAL FVECSGRADR
     DQLQLDDLVF PDPLKAFDAE ITPLGLQCFC LRKGNQKTEM NWIVPQLMAI VVNILDRSSG
     DRAGSNGKAP EEDRNKRLKV SKNFEELMRN SRSMITPRKL CALQTLPFLV GERDMESEEL
     SSVLLDLFNA CSDDNPVVSS WALLSIARWD SCRFLHVS
//