ID A0A2T7A7Z6_TUBBO Unreviewed; 1475 AA.
AC A0A2T7A7Z6;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Pleiotropic drug resistance protein, ABC superfamily {ECO:0000313|EMBL:PUU83854.1};
GN ORFNames=B9Z19DRAFT_1118564 {ECO:0000313|EMBL:PUU83854.1};
OS Tuber borchii (White truffle).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC Pezizales; Tuberaceae; Tuber.
OX NCBI_TaxID=42251 {ECO:0000313|EMBL:PUU83854.1, ECO:0000313|Proteomes:UP000244722};
RN [1] {ECO:0000313|EMBL:PUU83854.1, ECO:0000313|Proteomes:UP000244722}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tbo3840 {ECO:0000313|EMBL:PUU83854.1,
RC ECO:0000313|Proteomes:UP000244722};
RG DOE Joint Genome Institute;
RA Murat C., Kuo A., Barry K.W., Clum A., Dockter R.B., Fauchery L., Iotti M.,
RA Kohler A., Labutti K., Lindquist E.A., Lipzen A., Ohm R.A., Wang M.,
RA Grigoriev I.V., Zambonelli A., Martin F.M.;
RT "Draft genome sequence of Tuber borchii Vittad., a whitish edible
RT truffle.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000256|ARBA:ARBA00006012}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PUU83854.1}.
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DR EMBL; NESQ01000006; PUU83854.1; -; Genomic_DNA.
DR STRING; 42251.A0A2T7A7Z6; -.
DR Proteomes; UP000244722; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010929; PDR_CDR_ABC.
DR PANTHER; PTHR19241:SF498; ABC TRANSPORTER PROTEIN; 1.
DR PANTHER; PTHR19241; ATP-BINDING CASSETTE TRANSPORTER; 1.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF06422; PDR_CDR; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000244722};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 513..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 622..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 651..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 759..780
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1172..1195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1207..1228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1248..1273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1293..1317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1329..1353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1445..1466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 140..401
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 838..1080
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1475 AA; 164858 MW; B5734D44E8EDB7C9 CRC64;
MAGSGEEVGT GGPGPGCQNR LPPSTSSSEE TATSNHPNTR HEDIITPETE RDVTALARKL
TKISTSSSVV ENPFNSTDPR LQPNSDQFNV KTWVKTLIQI MSRDPELYPN RTAGVSFRNL
SVHGFGSQQD YQKDVSNLWM EGIDVLRNVL GGGRPGGKRG ERKIQILRNF DGLVKSGEML
VVLGRPGSGC TTFLKTIAGE THGFYLDSES DIEYQGISHE LMHHDFRGEV IYNAETDVHF
PHLTVGETLS FAAQTRAPRN RLPGVTRKQY AEHMRDVVMA VFGISHTSNT KVGDDFVRGV
SGGERKRVSI AEAALSGSPL QCWDNSTRGL DSATALEFVK TLKIQSEISG ATVLVSMYQA
SQSSYDYFDK VTVLYEGRQI YFGRTENAKR FFVDMGFHCP ERQTTADFLT SLTSPSERQA
KPGFENRVPR TPDEFAEVWK KSDEYQKLLH DIVAYKEEFP LHGPQLDAFK KSRAAQQAKR
MNVRSPYTIS VPMQIKLCIE RGFQRLNGDM TTFFSTIFGN VTTSLILGSV FYNLKQDTST
FYSRGALLFF AILMNAFSSA LEIHTLYAQR PIVEKHSQYA LYHPFSEAIA SMICDLPLKL
LSCISFNLTL YFMTNLRREV DAFFIFLLFS FVCTLTMSMM FRTIAAVSRT IYQALAPASL
LILMLIIYTG FAIPLRDMAG FMRWLNYIDP IGYAFESLMI NEFHDRELPC VGFIPRGPGY
ERVSGLQRSC TTPGAVPGRS TVNGDAYINT AFKYYYSHLW RNLGIMFAIM LFFLATYLIA
TEKISSARSK GEVLVFPRKQ LKKRAAHGDR EAGASDSVVA GSEASGVAVA IHRQTDIFHW
KDVCYDITIK GEGRRILDHV DGWVKPGTLT ALMGVSGAGK TTLLDVLANR VTMGVVAGDM
FVNGRLRDSS FQRKTGYVQQ QDLHLETSTV REALVFSALL RQPKKYSEQE KLDYVEEVIK
LLEMEEYAEA VVGVPGEGLN VEQRKRLTIG VELAAKPELL LFLDEPTSGL DSQTAWSICT
LLRKLANNGQ AILCTIHQPS ALLMQNFDRL LFLARGGKTV YFGPIGQNSE ILTGYFEKNG
SHKCPPGGNP AEWMLEVIGA APGAVATKDW VEVWNSSPEK VTVRTELDQM ERELGALSRA
EGAGTEEFAM PFSTQLRMCL LRVFQQYWRT PVYIYSKSFL CISTAIFIGL SFLNADNSIQ
GLQNQMFSIF MLMTLFGTLV QQIMPNFVTQ RSLYEARERP SKAYSWKAFL LSNIIVELPW
QTLMALLTFL LWYYPIGMYK NAKIAGELDE RGFLMFLLIW AFYMFASTFA HMMIAGIETA
EAGGNISNLL FMLCLIFCGV LASKDVLPGF WIFMYRISPL TYLVSAILSV GVAKAPVVCS
SIEIVKVVPP NGSTCGKYLS SFINSAGGLL YNPESTGECH YCPITNADSF LKEVDIDYAD
RWRNFGLMLV YIAFNLAAAV FIYWLARVPK KGKKL
//
