ID A0A2T7EGM1_9POAL Unreviewed; 3649 AA.
AC A0A2T7EGM1;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=GQ55_3G393500 {ECO:0000313|EMBL:PUZ66978.1};
OS Panicum hallii var. hallii.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Panicinae; Panicum;
OC Panicum sect. Panicum.
OX NCBI_TaxID=1504633 {ECO:0000313|EMBL:PUZ66978.1, ECO:0000313|Proteomes:UP000244336};
RN [1] {ECO:0000313|EMBL:PUZ66978.1, ECO:0000313|Proteomes:UP000244336}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. HAL2 {ECO:0000313|Proteomes:UP000244336};
RA Lovell J., Jenkins J., Lowry D., Mamidi S., Sreedasyam A., Weng X.,
RA Barry K., Bonette J., Campitelli B., Daum C., Gordon S., Gould B.,
RA Lipzen A., MacQueen A., Palacio-Mejia J., Plott C., Shakirov E., Shu S.,
RA Yoshinaga Y., Zane M., Rokhsar D., Grimwood J., Schmutz J., Juenger T.;
RT "WGS assembly of Panicum hallii var. hallii HAL2.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the UPL family. TOM1/PTR1 subfamily.
CC {ECO:0000256|ARBA:ARBA00034494}.
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DR EMBL; CM009751; PUZ66978.1; -; Genomic_DNA.
DR STRING; 1504633.A0A2T7EGM1; -.
DR EnsemblPlants; PUZ66978; PUZ66978; GQ55_3G393500.
DR Gramene; PUZ66978; PUZ66978; GQ55_3G393500.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000244336; Chromosome 3.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd00078; HECTc; 1.
DR CDD; cd14327; UBA_atUPL1_2_like; 1.
DR Gene3D; 6.10.250.1630; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR010309; E3_Ub_ligase_DUF908.
DR InterPro; IPR010314; E3_Ub_ligase_DUF913.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR025527; HUWE1/Rev1_UBM.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR003903; UIM_dom.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR PANTHER; PTHR11254:SF398; HECT-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR Pfam; PF06012; DUF908; 1.
DR Pfam; PF06025; DUF913; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00627; UBA; 1.
DR Pfam; PF14377; UBM; 3.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS50030; UBA; 1.
DR PROSITE; PS50330; UIM; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000244336};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 1296..1337
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 3308..3649
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 928..948
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 993..1035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1164..1184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1356..1376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1712..1768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2042..2225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2380..2444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2493..2578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2595..2620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2711..2747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2944..2985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3189..3221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2917..2944
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 995..1023
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1712..1731
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2043..2096
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2097..2126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2147..2185
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2200..2225
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2388..2403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2416..2430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2495..2510
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2545..2570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2595..2613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2957..2985
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3199..3221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 3616
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 3649 AA; 402413 MW; CF8E6B5BA7D4ABD6 CRC64;
MAAAMAAHRA SFPLRLQQIL AGSRAVSPAI KVESEPPANV KEFIDRVINI PLHDIAIPLS
GFRWEFNKGN FHHWKPLFMH FDTYFKTYIS SRKDLLLSDD MVEADPLPKN TILKILRVMQ
IVVENCQNKS SFTGLEHFKL LLASSDPEIV VAALETLAAL VKINPSKLHM NGKLISCGAI
NTHLLSLAQG WGSKEEGLGL YSCVVANEGN QQEGLTLFPA DLENKYDGAQ HHLGSTVHFE
YNLGPGLDPD QTSDKSKSSN LCVIHIPDMH LQKEDDLSIL KQCVDKFNVP PEHRFALLTR
IRYARAFNSA RTCRLYSRIS LLSFIVLVQS SDAHDELTSF FTNEPEYINE LIRLVRSEDF
VPGPIRALAM LALGAQLAAY ASSHERARIL SGSSIISAGG NRMVLLSVLQ KAISSLNSPN
DTSAPLIVDA LLQFFLLHVL SSSSSGTTVR GSGMVPPLLP LLQDNDPSHM HLVCLAVKTL
QKLMEYSSPA VSLFKDLGGV DLLSQRLHVE VQRVIGTVDG HNSMVTDAVK SEEDHLYSQK
RLIKALLKAL GSATYSPGNP ARSQSSQDNS LPVSLSLIFQ NVEKFGGDIY FSAVTVMSEI
IHKDPTCFPA LKELGLPDAF LLSVTAGVVP SCKALICVPN GLGAICLNNQ GLEAVRETSA
LRFLVDTFTS RKYLMPMNEG VVLLANAVEE LLRHVQSLRS TGVDIIIEII NKLCSSQEDK
SNEPAISEEE KTDMETDVEG RDLVSAMDSS AEGMNDEQFS HLSIFHVMVL VHRTMENSET
CRLFVEKGGL QALLTLLLRP SITQSSGGMP IALHSTMVFK GFTQHHSTPL ARAFCSSLRE
HLKSALEELN KVSSSIEMSK LEKGAIPSLF VVEFLLFLAA SKDNRWMNAL LSEFGDASRE
VLEDIGRVHR EVLCKIALFE ENKIDSEASS SSSASEAQQP DSSASDIDDS RYTSFRQYLD
PLLRRRGSGW NIESQVSDLI NIYRDIGRAA SDSQRVGSDR YSNQGLPSSS QDQSSSSSDA
NASARSEEVK KKSEHSSCCD MMRSLSYHIN HLFMELGKSM LLTSRRENSP VNLSPSVISV
AGNIASIVLE HLNFEGHSVS SEKEIAVTTK CRYLGKVVEF IDGILMDRPE SCNPIMVNSF
YCSGVIQAIL TTFQATSELL FTMSRPPSSP MDTDSKTGKD GKETDSSWIY GPLSSYGAVM
DHLVTSSFIL SSSTRQLLEQ PIFNGSVRFP QDAERFMKLL QSKVLKTVLP IWAHPQFPEC
NIELISSVTS IMKHVCTGVE VKNTVGNGSA RLAGPPPDEN AISLIVEMGF SRARAEEALR
QVGTNSVEIA TDWLFSHPEE PQEEDDELAR ALAMSLGNSD TSAQEEDSRS NDLELEEETV
QLPPIDEILY SCLRLLQTKE ALAFPVRDML VTISSQNDGQ NRVKVLTYLI DNLKQCVMAS
ESLKDTTLSA LFHVLALILH GDTAAREVAS EAGLVKVALD LLCSWELGPR ESEVAEVPNW
VTSCFLSVDR MLQVEPKLPD VTELDVLKKE NSNTKTSLVI DDNKKKDSES LSSVGLLNLE
DQKQLLKICC KCIEKQLPSA SMHAILQLCA TLTKVHAAAI CFLESGGLNA LLSLPTGSLF
SGFNNVASTI IRHILEDPHT LQQAMELEIR HSLVTAANRH ANPRVTPRNF VQNLAFVVYR
DPVIFMKAAQ AVCQIEMVGD RPYVVLLKDR EKDRSKEKDK DKDKPADKDK ASGAATKVTS
GDIAAGSPAS AQGKLPDLNA RNVKPHRKPP QSFVTVIEHL LDLVISFVPP PRSEDQADVV
SCTASSSDMD IDCSSAKGKG KAVAVAPEES KHSVQEATAS LAKSAFVLKL LTDVLLTYAS
SIQVVLRHDA DLSNMHGPNR PGAGIISGGI FTHILQHFLP HAVKQKKDRK TEGDWRYKLA
TRANQFLVAS SIRSAEGRKR IFSEICSMFL DFTDSSTAYK APVSRLNAYV DLLNDILSAR
SPTGSSLSAE SAVTFVEVGL IQSLSRTLQV LDLDHPDSAK IVTAIVKALE VVTKEHVHSA
DLNAKGENSS KIASDSNNVD SSSNRFQALD TTSQPTEMVT DDREASNAVQ TSQSSDSVED
EMDHDRDMDG GFARDGEDDF MHEMAEDGTG NESTMEIRFE IPRNREDDMA DDDEDTDEDM
SADDGDEVDE DDEDEDEDEE NNNLEEDDAH QMSHPDTDQD DREMDEEEFD EDLLEEDDDE
DEDEEGVILR LEEGINGINV FDHIEVFGGS NNLAGDTLRV MPLDIFGTRR QGRSTSIYNL
LGRASDHGVL DHPLLEEPSS ILNLPHQGQQ PENLVEMAFS DRNHESSSSR LDAIFRSLRS
GRNGHRFNMW LDDSPQRSGS AAPAVPEGIE ELLISHLRRP TPEQPDVQRT PAGATQENEQ
PTNVSEAEAR EEAPAEQNEN SVNTVNPVDL SENAEPAPPD SDVLQRDVSN ASEHATEMQY
ERSDVVARDV EAVSQASSGS GATLGESLRS LEVEIGSVEG HDDGDRHGAS GASDRLPLGD
MQATARSRRP SGSAVPLGSR DISLESVSEV PQNPNQEPDQ NANEGNQEPT RAADADSIDP
TFLEALPEDL RAEVLSSRQN QVAQTSNDQP QNDGDIDPEF LAALPPDIRE EVLAQQRAQR
LQQQSQELEG QPVEMDAVSI IATFPSEIRE EVLLTSPDTL LATLTPALVA EANMLRERFA
HRYHSSSLFG MNSRNRRGES SRREVMAAGL DRNGDPSRST SKPIETEGAP LVDEDALKAL
IRLLRVVQPL YKGQLQRLLL NLCAHRDSRK SLVQILVDML MLDLQGSSKK SIDGTEPPFR
LYGCHANITY SRPQSSDGVP PLVSRRVLET LTYLARSHPN VAKLLLFLEF PCPSRCHTEA
LDQRRGKAVV EEGEERKAFA LVLLLTLLNQ PLYMRSVAHL EQLLNLLEVV MLNAENQINQ
ARLEVSSEKP SGPENAVPDG QDNTNVSESS GSKSNAEDSS KTPVDNENNL QAVLQSLPQP
ELRLLCSLLA HDGLSDNAYL LVAEVLKKIV ALAPFFCCHF INELARSMQN LTLCAMKELR
LYENSEKALL SSSSANGTAI LRVVQALSSL VTTLQEKKDP ELPAEKDHSD AVSQISEINT
ALDALWLELS NCISKIESSS EYVSNLSPAS ANAPTLATGV APPLPAGTQN ILPYIESFFV
TCEKLRPGQP DAVHEASTSD MEDASTSSGG QRSSSGQASL DEKQNAFVKF SEKHRRLLNA
FIRQNPGLLE KSFSLMLKIP RLIDFDNKRA YFRSKIKHQH DHHHSPVRIS VRRAYILEDS
YNQLRMRSPQ ELKGRLTVHF QGEEGIDAGG LTREWYQSLS RVIFDKGALL FTTVGNDLTF
QPNPNSVYQT EHLSYFKFVG RVVGKALFDG QLLDAHFTRS FYKHILGAKV TYHDIEAIDP
AYYKNLKWML ENDISDVLDL TFSMDADEEK LILYEKAEVT DCELIPGGRN IRVTEENKHE
YVDRVAEHRL TTAIRPQINA FLEGFNELIP RELISIFNDK ELELLISGLP DIDLDDLKAN
TEYSGYSIAS PVIQWFWEIV QGFSKEDKAR FLQFVTGTSK VPLEGFSALQ GISGPQRFQI
HKAYGSTNHL PSAHTCFNQL DLPEYTSKEQ LQERLLLAIH EANEGFGFG
//