ID A0A2T7NB33_POMCA Unreviewed; 982 AA.
AC A0A2T7NB33;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN ORFNames=C0Q70_20918 {ECO:0000313|EMBL:PVD18369.1};
OS Pomacea canaliculata (Golden apple snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Architaenioglossa; Ampullarioidea; Ampullariidae; Pomacea.
OX NCBI_TaxID=400727 {ECO:0000313|EMBL:PVD18369.1, ECO:0000313|Proteomes:UP000245119};
RN [1] {ECO:0000313|EMBL:PVD18369.1, ECO:0000313|Proteomes:UP000245119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SZHN2017 {ECO:0000313|EMBL:PVD18369.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PVD18369.1};
RA Liu C., Liu B., Ren Y., Zhang Y., Wang H., Li S., Jiang F., Yin L.,
RA Zhang G., Qian W., Fan W.;
RT "The genome of golden apple snail Pomacea canaliculata provides insight
RT into stress tolerance and invasive adaptation.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVD18369.1}.
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DR EMBL; PZQS01000014; PVD18369.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T7NB33; -.
DR STRING; 400727.A0A2T7NB33; -.
DR EnsemblMetazoa; XM_025223957.1; XP_025079742.1; LOC112555524.
DR Proteomes; UP000245119; Miscellaneous, Linkage group lg14.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24369:SF210; CHAOPTIN-RELATED; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR Pfam; PF13676; TIR_2; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00082; LRRCT; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 2.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 2.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245119};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 594..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 644..778
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT DOMAIN 841..981
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 982 AA; 112942 MW; 850FC0747F6966C5 CRC64;
MNNWAVEDDL HLLSTCTGKL DNVVEVALAN ISLKTFPEIL HTVMPNLIAL EFSNNHLWAP
VDFDWISSLV ELPRNLSRTS QFNNLYSYYG AIDIQPNLFR REYILNGNNI TNLTHFYFRG
EFQYVSLERN GMTEIGEEVF YHIPDLQFLS LADNVLESLP ENLFSSLRKL KRLDLQGNRL
KYLPTNLFRN LLQIQQLNLD GNKLEKLQDG LFANLEQLTC VHLKGNNLMH VSDKAFDTLS
IKLSLLDLSE NPLKEIPPII FLLRGLVNTN LESTDIEVLD FVEIINRTST YWILENFKNP
TTGDANFRAA PNLQRVVSLR NSKLRSIVMY NSTEEIINTF TLLAKYFTFQ TDGAHLSCDC
NILNVTHLVT ELREKGDLSG TEVLFTGWTC SWPDQLRQRT VASLRDEETY CPFREERNLT
TRCPDPCNCY VRTSVSTIIV DCQHAGLTSL PAFVPTRTRD MWLQNNMIKT VEALPYLQQL
HTLKLSANNL QELPKKVLDQ LTSLHVLHVD DNWLTTLLPD LGDLQQIRSV RLSGNPFRCD
CNTRWLKRWV LDPKVEVEDW NDIKCSLDDD EGQLITRVPD EKFVCKIAPS LTQLAVHIAV
PLSLALLLVV LAVIAFIYRR QLKVQLYIYT GLHTFDRDPS KDRFLYDVTV CCSLGDQDWV
LTNVVTVLEM AYNYKVFFLN RDAFLGYSIS NNVRHCVKKS RLLVVVLAKD WDSEETLVTA
VRQGLDKCRK DMVHFLTVVL HETSPRDIQD KDLQQFVKKG RFLTTSESHF HKKLAYEMPH
LQTDKIFFCC RNVRKPEGVV KFHDIVAITE NQQNVILEIG AAPSEGCDRR VCKLPSTGER
ATKSVFVWYS DVDLTYTVES IVKPLESRGH QCIVQDRDFP LGAAIQDNIV RAADSCSLAV
FVLSDDIGAS EWFLFTFHVV FDRCQQHRDR RVLLVLRAAL NADNLTDDVQ QAVRTSAVLR
EQDPWFESRL QKFAELDFKE MY
//