ID   A0A2T7NMC3_POMCA        Unreviewed;       769 AA.
AC   A0A2T7NMC3;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   RecName: Full=IRS-type PTB domain-containing protein {ECO:0000259|Pfam:PF02174};
GN   ORFNames=C0Q70_18120 {ECO:0000313|EMBL:PVD22311.1};
OS   Pomacea canaliculata (Golden apple snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Architaenioglossa; Ampullarioidea; Ampullariidae; Pomacea.
OX   NCBI_TaxID=400727 {ECO:0000313|EMBL:PVD22311.1, ECO:0000313|Proteomes:UP000245119};
RN   [1] {ECO:0000313|EMBL:PVD22311.1, ECO:0000313|Proteomes:UP000245119}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SZHN2017 {ECO:0000313|EMBL:PVD22311.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PVD22311.1};
RA   Liu C., Liu B., Ren Y., Zhang Y., Wang H., Li S., Jiang F., Yin L.,
RA   Zhang G., Qian W., Fan W.;
RT   "The genome of golden apple snail Pomacea canaliculata provides insight
RT   into stress tolerance and invasive adaptation.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PVD22311.1}.
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DR   EMBL; PZQS01000011; PVD22311.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2T7NMC3; -.
DR   STRING; 400727.A0A2T7NMC3; -.
DR   Proteomes; UP000245119; Miscellaneous, Linkage group lg11.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR002404; IRS_PTB.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR21258; DOCKING PROTEIN RELATED; 1.
DR   PANTHER; PTHR21258:SF56; INSULIN RECEPTOR SUBSTRATE 1; 1.
DR   Pfam; PF02174; IRS; 1.
DR   SMART; SM01244; IRS; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000245119}.
FT   DOMAIN          94..187
FT                   /note="IRS-type PTB"
FT                   /evidence="ECO:0000259|Pfam:PF02174"
FT   REGION          312..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          436..477
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          503..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          563..674
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        316..349
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        363..384
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        463..477
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        563..592
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        608..624
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        656..674
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   769 AA;  85562 MW;  0A6258290A093177 CRC64;
     MSLTLTSPAV KSTFSDEKSS WNNQNQTDYH TLPRHFEMSV DKLSNINGRA FAVQITSPDH
     QLCFSADEQS TIDIFVFLLQ SQVMLRETIK DGLFNVEPEE SEAFRRIGAK GAKYLLHVSP
     WGLSLVLQRS RCVLAQWPLK SIRFYESSGG GQFTIEAGKV APMGEGVFVF HTQPGIDSQL
     YSAVDHFIIS TLDRVKPNQR GTAEEIEDYI RERDCLQSVT LLSPSQFARS ELKKILQDNW
     NYILPSAGIN RSGSESTSDD ASSLVSCHLL ASATHHHSTD WCQTTALDLS HPLKLPRLTL
     FKGKRVDLLR KGSGRLAKSS PTNRMDSVLE SPPQSPEAND AQFHLSSPEV TLRSRPDGAS
     HHLSARQLSQ ESTASQSSDL SPAQFQASNA AAVLERQSQP VVLHGDHAKI EQSVEEWLVS
     ASCEDLSDHM RTVIFRPQSS GPPVSDNNKP VASAADGDSK EIRLGGNSSS KITPPPFVNI
     QQYRSSVEWG KDKVRDRSYS FDAKTKNSVD TSRPVTHDGL GHKPSIRQIR KMVAARSVTK
     ENLQKSLSNP SFLNLGSKEQ LSQHRIQLTK TSSHNKDASK LSNQSKKKSR SLASLLPSPL
     RRYVSKESIS RPASSSPSPN LRQHRRDSSA GRSNFQRFDS ARSLQEMTIK GIHFTEQSRS
     FRKPKSSDAR GNRDKNDKMV SYAVKNLLAQ DVTLPQLTSL HSSMEHEQNL SETERPVVTN
     CDVQQPQSLI DSKVQQQHTQ ERHVQNGVPR LTGNTLQTYV PSHSIDESF
//