ID A0A2T7NTR9_POMCA Unreviewed; 447 AA.
AC A0A2T7NTR9;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=C0Q70_15038 {ECO:0000313|EMBL:PVD24555.1};
OS Pomacea canaliculata (Golden apple snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Architaenioglossa; Ampullarioidea; Ampullariidae; Pomacea.
OX NCBI_TaxID=400727 {ECO:0000313|EMBL:PVD24555.1, ECO:0000313|Proteomes:UP000245119};
RN [1] {ECO:0000313|EMBL:PVD24555.1, ECO:0000313|Proteomes:UP000245119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SZHN2017 {ECO:0000313|EMBL:PVD24555.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PVD24555.1};
RA Liu C., Liu B., Ren Y., Zhang Y., Wang H., Li S., Jiang F., Yin L.,
RA Zhang G., Qian W., Fan W.;
RT "The genome of golden apple snail Pomacea canaliculata provides insight
RT into stress tolerance and invasive adaptation.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVD24555.1}.
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DR EMBL; PZQS01000009; PVD24555.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T7NTR9; -.
DR STRING; 400727.A0A2T7NTR9; -.
DR EnsemblMetazoa; XM_025250710.1; XP_025106495.1; LOC112571598.
DR Proteomes; UP000245119; Miscellaneous, Linkage group lg9.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46006:SF8; DH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000245119}.
FT DOMAIN 111..293
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 323..433
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 447 AA; 50567 MW; A2D9D2B73E3BE038 CRC64;
MENPILRKRK RKDEDATSVQ SLDVGSNTKS KKSRRSILRV SSSLVNLLSP SKPQKRNSSG
FKMPNSPAAK QCISPYKIPS PSPAQRRLTR TWSDMMAGGS SVASMTPQDI KRQEAIYELY
QGEIDIVEDL NNVKKLYRDS MLTLHLCTAG ELSQIFGPID DLLPVHEDLA QRLQRQRQTD
GTMQGVGQQI LQWVPKLVVY TNFCANQVFG KALLDEKRSD PAIDDFLRRC QESPFSRKLD
LWGLLDGARG RFIKYPLLIK SILKETPHDN EDAPLLKQAL EQLDLIIQTA DTCTGEAECS
FYKSRLVYIY DEQRVPEIEE SKVLMCHGHL RNNKGSKLQL FLFEKVAVVT RPSSQGPQVY
RQPIPVTHLV VEDLPDGEIK IGSFRNAFGP GQTAKNVLRV SFTDSKMGQS HTLMANDEHD
KRQWMQSFQA VTSHIVKVGL SIDRDKK
//
