ID A0A2T7NUQ2_POMCA Unreviewed; 3211 AA.
AC A0A2T7NUQ2;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN ORFNames=C0Q70_15383 {ECO:0000313|EMBL:PVD24893.1};
OS Pomacea canaliculata (Golden apple snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Architaenioglossa; Ampullarioidea; Ampullariidae; Pomacea.
OX NCBI_TaxID=400727 {ECO:0000313|EMBL:PVD24893.1, ECO:0000313|Proteomes:UP000245119};
RN [1] {ECO:0000313|EMBL:PVD24893.1, ECO:0000313|Proteomes:UP000245119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SZHN2017 {ECO:0000313|EMBL:PVD24893.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PVD24893.1};
RA Liu C., Liu B., Ren Y., Zhang Y., Wang H., Li S., Jiang F., Yin L.,
RA Zhang G., Qian W., Fan W.;
RT "The genome of golden apple snail Pomacea canaliculata provides insight
RT into stress tolerance and invasive adaptation.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVD24893.1}.
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DR EMBL; PZQS01000009; PVD24893.1; -; Genomic_DNA.
DR STRING; 400727.A0A2T7NUQ2; -.
DR Proteomes; UP000245119; Miscellaneous, Linkage group lg9.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 2.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000245119}.
FT DOMAIN 1479..1618
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2056..2203
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 78..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2895..2939
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3211 AA; 366254 MW; DB4C485A040B8EDD CRC64;
MTSVVGPSGR QFEVLTTEGS DCKLHTSTAR LCVATRLLNE TVDNCVLGDA ISEKSLTGAG
TTLYIHHCQP ATLSLRTNTG RVGEGGEREG VVGGRSLENT HTPSTGIIHS TFPLLFNAVN
LVPSAHPPSF HPAMFAFVCA NTLITTQSLL LPPPPDLIIN VLIGEAQVHG GPVAQPSEFE
AKYRPAFICH LPPLSASLPA FSERPRIVEQ ASYTKAAPVK EKKYFRRVSD SIGNNYSPGA
NKFTTSLIYN TTRGEDENEY DEEEIRTAND HDNSDGDVYH NGDEHDEETR QVLHVQFPPW
YFSTHGLSRP TSPDPENKER YYTLLEQAIP PDMVGPITDD TLQGIYRFVP HHLRSSFAQA
TTEFLQEMDE DYRVAVRRAI LDYILLDPVE QDRLGLAMPF KPSHSAGRDS FPWHSRVLAT
RTFMETDLYI THPVMIKILY HFESKYGTLR LIDLPGLKGQ MPVTMETFVK HVQDSSAEGF
QRLSRDWVAE CCTIVDEHRD AIEMTMPRET KERMNKLDHF FGSVASLMSI LLRRCVQASI
EDLVSFVEEY DSGNAYDGTY TMTSSLALPS RGHPVSLFLK EDVDSSALCF RPSLDLCNSF
SLIVDTMVTC VQQVKRVEHF LFQDVEELPV RYVSSVGVQE ELVEQAKGRL HTVIVANSHG
PLKYKSVYEP YRYLYSRDTD QAVHRFVSRD RSLREYSHEI ERLKRMASDV GSFPVFVPMH
FFLLDCTHMN QWLIDKARDL NNIMVRKIMD TSDKFNRQIC SQYDTIVKRS SYQAENTQEL
VKLQDYVEGL RVGELLELKD KLEIAGGNLL FLMDYAYLPK DNILINCTTF TWPDRIIPIV
RNAENKLQRE HDMAINRLSD WRKRFQAQLD EAVKKVKDFA SKDRMSEADK YLADLVDLDS
KLQVFKEEKV KINREEQMLG METQTEYAQI GVIQVAKEPY DKLWSTAVKF HQQHDKWMNG
PLLEVNAEHV EEEVQNLWRV AYKLTKVFAH PDYKGPMRAS ATIKTKLEKF KINMPLINAL
CNPGIKQRHW NMMSEKVGFN MAPSEATPLH EVLQMGLEKY LDELMGISSR ASKEFALEKA
LTKMRDDWSN MTFTFVSYKD TDVSILASFD DIQVLLEDHI VKTMTMKGSP FIGPFEKEIG
EWDQNLAAWL YLEPIFGSQD IRNQIPVEGK LFEEVDAQWR GMMKQAVVNT KALVVVAQDR
MLENLEHSES MLDDIQKGLN DYLEKKRLFF PRFFFLSNDE LLEILSETKD PLRVQPHLKK
CFEGIACLSF SADKVIEAME SAEKEKVPFS RTITPEDAHG LVELWLAQVR HVIILSYYEM
GRSAFVWAVT PRRQWVLQWP GQVVLASSQT HWTVEVTNAI SYGGLQAYLG KSNKQVEEIV
QMVRGRLSKM ARITLEALIV IDVHARDVIA TLHKQQARSP LDFSWISQLR YYFENDLVQV
RMITTTVAYA YEYLGNTGRL VITPLTDRCY RTLMGALQLN LGGAPEGPAG TGKTETSKDL
AKAVAKQCVV FNCSDGLDYK AMGKFFKGLA QSGAWACFDE FNRIELEVLS VIAQQVQTIQ
RAIAEQKQKF VFEGTEISLD PSCTIFITMN PGYAGRAELP DNLKVLFRTV AMMVPDYGLI
GEISLYSMGF VEARALATKI VATYRLCSEQ LSSQHHYDYG MRAVKSVLTA AGSLKLKYPD
QREDVLVLRS INDVNLPKVI LSHDIPLFEG IISDLFPGVD LPNPDYDHLE KAVQEKMAAA
NLQCVPWFIT KVIQVMYNII NPKAITMGQL YGRFDPVSHE WTDGVLANTF RAHASTPTED
RKWIVFDGPV DAVWIENMNT VLDDNKKLCL MSGEIIQMNN KQNMIFEPQD LEQASPATVS
RCGMIYMDPL QLSWEPLIAS WMRTRLPDIL TKEQREMIKL LFEWILPPCL GFVGKYCRHI
LTCHPMHLTA SALKLYECLM EDVKKIGKDD FDDFIAEEVT RRGRGGVFRS HGGPSSHVSH
GAEDPKTLKF ARALLIPKKG TVFDYVYIQK QYGSWNTWSG LVSPVSIDAK THLSALIVNT
VDTVRQRFFL SRFLSLDKAV LFVGPTGTGK SAITNNHLLE LPRDQYVTCN INFSAQTSAN
QTQDIIFSKL DRRKKGTYGP APGKKLCVFV DDLNMPAKER YGAQPPIEIL RQWIDHGFWY
DRKDTSILQL SDVVMLCAMG PPGGGRNMVT PRFLRHFNII GIETFDEETM KSIFAPIIDW
HFNFFETPQR RFARIILTCT LEVYQEAISN FLPTPSKSHY LFNLRDFARV VQGVLLLKPR
VVPSGVEGAQ KICRMWIHEV YRVFYDRLVD DSDRETFFRI VKTKVEMHFK EKLNNLFSHI
VDASRLIVDD DIRSLIFGDY LKKKEDEKLY DEIQNLDELR EVVEHYLAEY NMMSKAPMDL
VMFRFAIEHI SRISRVLKQP NGHCLLVGIG GSGRQSTTRL AAFMSDFELF QIEITKNYTV
SDWRDDLRKM MRRAGDEGVS TVFLFGDHQI KDESFLEDIN MILNTGDIPN LYDNEERLAI
IERMQTVCQL ENLQIEFTPL NMYNKFVERI RRHLHVVLAF SPIGDAFRNR LRMFPSLINC
CTIDWFKLGD ILCHGAISRS STIDHELFTA RATGMARGRL ELVANKFLDD VEMQTEVRGE
MVAMCKHFHQ SVRALSVTYY ETMRRQNYVT PTSYLELIKN FKNLLNQKRM EILTLKNRYM
VGLEKLAFSE AQINVMQQEL VELQPKLIET SRETEELIGI IETETVQVEA KKTLVEADEA
VANKAAMEAK EIKDDCEARL AVAMPAMEAA ISALDTLKQN DITIVKTMQN PPSGVKVVME
SVCILKGIKP EKKVDSMEKL LRITGLRLKR DKYINNPEFD PAIIKNVSSA CEGLCKWVRA
VEVYDGVAKV VAPKQESLKE AEEVLADQMS KLRQKQAELK EVTDKLQGLN DNLALKQEEK
AVSRQHRMCK VKIERAEKLI SGLGGEKDRW TQNVEELTER YDNIIGDVLL SAAVVAYLGP
FILDFRQDCI RGWFTLCKEK AIPISEPFSM SKTLGDAVMI REWQIAGLPA DNYSVDNAII
VKSANRWPLM IDPQGQANKW IKNMEKVNKL EVIKFSDPNY VRSLENCLQF GNPCLLENIG
EELDPILDSI LLKQTFKQNG LDYIRLGDHV VEFSRDFKFY ITTRLRNPHY LPEVSVKVTL
LNFVITPLGL EDQLLGLVAA KEKPQLGEEE E
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