ID A0A2T7P0A1_POMCA Unreviewed; 968 AA.
AC A0A2T7P0A1;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Kazal-like domain-containing protein {ECO:0000259|PROSITE:PS51465};
GN ORFNames=C0Q70_12005 {ECO:0000313|EMBL:PVD26857.1};
OS Pomacea canaliculata (Golden apple snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Architaenioglossa; Ampullarioidea; Ampullariidae; Pomacea.
OX NCBI_TaxID=400727 {ECO:0000313|EMBL:PVD26857.1, ECO:0000313|Proteomes:UP000245119};
RN [1] {ECO:0000313|EMBL:PVD26857.1, ECO:0000313|Proteomes:UP000245119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SZHN2017 {ECO:0000313|EMBL:PVD26857.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PVD26857.1};
RA Liu C., Liu B., Ren Y., Zhang Y., Wang H., Li S., Jiang F., Yin L.,
RA Zhang G., Qian W., Fan W.;
RT "The genome of golden apple snail Pomacea canaliculata provides insight
RT into stress tolerance and invasive adaptation.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVD26857.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; PZQS01000007; PVD26857.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T7P0A1; -.
DR Proteomes; UP000245119; Miscellaneous, Linkage group lg7.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd17336; MFS_SLCO_OATP; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR InterPro; IPR002213; UDP_glucos_trans.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF142; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 2.
DR Pfam; PF00201; UDPGT; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245119};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..968
FT /note="Kazal-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015700621"
FT TRANSMEM 397..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..585
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 605..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 802..828
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 840..859
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 892..914
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 727..775
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
SQ SEQUENCE 968 AA; 107277 MW; B1CD29E02CFFE234 CRC64;
MRQFLLLTAV CFLVLLPLCV GGKRVVFMPM PFTSHTNYHT NVARTLARQG HEVWLTMPDY
IVNRRVLDTT NLTVIEYQTL INFEEIMTAA HAGNYFKGLS EDWDVFMSIG LQFCDTLLTN
VSFYKKVKEL RPDLFVFDNL RFINMMTIIS YRLGVPFSFL GTAYAPSYQR IPLQPCNMPF
IIFSFNNHMS FFQRVLNTLI HVYASVGDGF SYKDAVSRYA PEMPFLTIDM LVARAEIWLV
ETDHILDYPR PSMPNVKLIG GTATGPGKQL PPQFKSFMDD ATEGVVIVSF GSYVLSPPEP
ITQKIISVLQ DLPFKSIFRS NISSPNSKKI LTCRGYLRMT CLLTPTLEYL SAIVRCARIG
CFTLLVSLTT LTTSTLNTYL NSQVTTLERQ FGLSSSISGM ILSCNELGYL LTILPFSHLA
RRLHVPRALA VTTMMFGLAG LVCTIPFLAS RNSLLAATWS LKDLNASQSD VSSSYIVPLC
ADDSFERSLD DNLSLTSNMS YGRDSCIAEN SRKKAAVSED WKGLAVAFLT IGMILQGCAK
SPRTVFTCVY IDDNVLKTES SLHMGIVGSI TLFGPVLAYV LGGVFTRLYI TLEDTGLSPL
DPRWIGAWWL GFLVFGITSI VTALPLVFFP RRLRPQPHLA ALKEERKRAA KGRQCTYGII
GLVNLMAMSL GTLIGGYVTS RFKFPPMTCL KVMVILNAVC TCISVSGFVL GCDQPHIDTG
VTSHSVMNTT QRCQSSCQCD DSRYFPTCGA DGVTYFSPCH AGCSETRGTF YGNCSCIEMP
KKTSQPVPEA VPGLCAQSCT TFYPYVAISF FLELLGAMSI LPCFIVVIRS IAEVDKPVAI
GLYSFLYTIL GWFPAPVLYG QVVDTTCLLW SSGCAGRGSC SLYDLRAFRH RMFGTFFTTR
VAHLVFLVIA LAVASRMKKP FFAHCEAEPE VSTVPKDEKV VLTKNMTTVE VVNKKEILCD
SLTSTTLV
//
