ID A0A2T7P472_POMCA Unreviewed; 1243 AA.
AC A0A2T7P472;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=G-protein coupled receptors family 2 profile 2 domain-containing protein {ECO:0000259|PROSITE:PS50261};
GN ORFNames=C0Q70_10806 {ECO:0000313|EMBL:PVD28219.1};
OS Pomacea canaliculata (Golden apple snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Architaenioglossa; Ampullarioidea; Ampullariidae; Pomacea.
OX NCBI_TaxID=400727 {ECO:0000313|EMBL:PVD28219.1, ECO:0000313|Proteomes:UP000245119};
RN [1] {ECO:0000313|EMBL:PVD28219.1, ECO:0000313|Proteomes:UP000245119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SZHN2017 {ECO:0000313|EMBL:PVD28219.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PVD28219.1};
RA Liu C., Liu B., Ren Y., Zhang Y., Wang H., Li S., Jiang F., Yin L.,
RA Zhang G., Qian W., Fan W.;
RT "The genome of golden apple snail Pomacea canaliculata provides insight
RT into stress tolerance and invasive adaptation.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVD28219.1}.
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DR EMBL; PZQS01000006; PVD28219.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T7P472; -.
DR STRING; 400727.A0A2T7P472; -.
DR Proteomes; UP000245119; Miscellaneous, Linkage group lg6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15040; 7tmB2_Adhesion; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR PANTHER; PTHR45692; G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45692:SF1; G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13855; LRR_8; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF57302; Snake toxin-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245119};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1243
FT /note="G-protein coupled receptors family 2 profile 2
FT domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015761326"
FT TRANSMEM 824..847
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 859..878
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 890..916
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 928..949
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 969..998
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1019..1038
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1044..1067
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 822..1068
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1113..1243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1160
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1243 AA; 136944 MW; E02B72C44991FBCC CRC64;
MLLAIVWCCL QFSGFAGCDI VCVADQDRAE VCRCPLYGQI HFECVEKNLT RIPTGLPATL
THLDLSYNHI TTVKKGDFSG LEGLQILRLR RNKISSIDRG VFENLYSLQE IDLSGNQLVH
ILSAWFQHLP SIKLINVSNN QIRIIEKKAF LTLPASQYPV TVDLEGNDIA CNCNIRALKK
WIANIPKDVS SVSLVNLQCS NRKKDLKDMT DSDFPNCVGS ELSVSESRGR CSTCSAASTH
SSCDVTLSSC DAREPWCFSS VTYSNGSLSI QKGCTNMRDC LKAERNNSRW CSTSGSQGRG
YMKCVFCCSG DLCNHDDQAG RTRSLVSFLT LLLSKPFQRY MMESFSTQRN IEKAFWTEQV
SKLLENLPGI PVINTEVDFL SFSNESSKLR VDFLLRQTFV SDVNSSTVLT AVFRKVQASD
VTGFLKNQSL SRIYVGSELN SSVLCPAEIN SFLGHELLWP ETDQDVTVRL PCNSPDEDSS
ANSFATRRCV MGNYGIARWG ELQLQNCRMI RPGELRKLEN VKINSDTVHG LLEQLDEVTR
GQGNMTSQEL VLVVNTLENS LAEGSALTVN TSVQAVVNVL STLLTVDESQ LQLAQEESKI
PERILKAVEE IGASAPLTDG SLKVTTPNLI VLATLAEPAM FPGLALVAER DSDNQFQDDK
VFLTDSTVST PQSTNKVYLP PSLLSSVNST SRIALSLFSS PVLFQAVEKS GKHDNMSSWT
SNAHINSIVM AASVVNTSIT DLTEPLHLTF THINNWSGNR NCVFWQADDK SGEWSSRGCK
VLTDLSSDNY TTCACDHMTN FALLMDVYST GSHLSAADKK ALSVISYAGC GISLLALTLT
LLTYLLFRKL RRDNPSRILI NLCAALLLSN LVFVAGMQDY TYSNEVACKA VAAILHFALL
AGICWMAVEA FYMYLALVRV FKTYFTCFLL KCCLVGWGIP LVIVMLTLIV NKSDNYARLD
SGICWLQGIA FHVAFVAPVC VVMAINFTAF ALVVWQLMGV AQRALTKSDS FSTIQRLRGA
VGVVILLGLT WIFAIFAIDL ASVPFYYLFA IFNSLQGLFI FVFYCVLKRD ARQAWKRKLP
CLPEEEESVS SRAQTGTSSR SYSRDAVATT YVNSTSSAKD SDRDAKITSR AKNESTSSLL
EENSDEASHE KDRNVSRRKL EEASNAASVP PTKGAHSLSG TEEKRELTAV SPIHRSPGGS
NSTHICGNTL TDKEKDTSDR TATCTGSIVS HPDQTPEREC SRL
//
