ID A0A2T7P490_POMCA Unreviewed; 1225 AA.
AC A0A2T7P490;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN ORFNames=C0Q70_10813 {ECO:0000313|EMBL:PVD28226.1};
OS Pomacea canaliculata (Golden apple snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Architaenioglossa; Ampullarioidea; Ampullariidae; Pomacea.
OX NCBI_TaxID=400727 {ECO:0000313|EMBL:PVD28226.1, ECO:0000313|Proteomes:UP000245119};
RN [1] {ECO:0000313|EMBL:PVD28226.1, ECO:0000313|Proteomes:UP000245119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SZHN2017 {ECO:0000313|EMBL:PVD28226.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PVD28226.1};
RA Liu C., Liu B., Ren Y., Zhang Y., Wang H., Li S., Jiang F., Yin L.,
RA Zhang G., Qian W., Fan W.;
RT "The genome of golden apple snail Pomacea canaliculata provides insight
RT into stress tolerance and invasive adaptation.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVD28226.1}.
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DR EMBL; PZQS01000006; PVD28226.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T7P490; -.
DR STRING; 400727.A0A2T7P490; -.
DR Proteomes; UP000245119; Miscellaneous, Linkage group lg6.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd22173; F-box_ECT2L; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR46857; EPITHELIAL CELL-TRANSFORMING SEQUENCE 2 ONCOGENE-LIKE; 1.
DR PANTHER; PTHR46857:SF3; F-BOX DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000245119}.
FT DOMAIN 789..978
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 661..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..707
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..722
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 723..751
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1225 AA; 140466 MW; 3EC1843E97901BA7 CRC64;
MAYSTNAKKK TVLMQTRLSI TDEDDSKVLG RTTNLRREKT ASMDQIHTLK LKTQNSAWTP
IVHKPSNEQI FKERRDLVSH WFDMWTDSQR KRFLDVLFRQ CSRSQYKFVQ DWFRERVPIQ
HLDFTTVLPR FLSLYIFSFL EPKSLCRCAQ VSWTWKFLSE QDDVWMTKCI RYGWFLPYTP
ADNEYGAWKR HYVACIHTLD SMEGSRQPKP PPPGYPEYME KPEISLKPTR LSRMDSRRLM
DIRPPWQGPD WKPKDLEQSN RAVAHGSNPN EPVRPKSDEV MHNRWGILKS RYNEAVTVRS
LDFEIGMDTD RRRDRHRILL AGEDYNIPKS SRKTLRETLI FQTNEERRME ELINTDWIPP
TSSVMKRYPK SRHQICNIQP GGNIVSSNPR IIIISSRIPG ADLLLDAVLF GVIPIVYEYE
GTVAQSLVEQ VESALQGRHA QSVGLFCHAE EPGQLCVAHG CTVSLTTLDT PVVSSFFESV
ANHILPADLG GQFDIFVPLA ASEEGMEMLV QLSIKTSMQF SSPTGIIGNY NHVNSSWLID
YNGKSPPEVY FCTSKLLVWA SVADQAQEAM KTCHEIMATF FEKTHRDIVA QLTGQMIFDV
LRQTDIQGVH DITHVLKDGL IALGDQKSVN PLEFLGYFLL ERAGSSTLTV SGSLQTLSRQ
QTLSSLTEGG DMEESRSGSR KKAEGADAGH VQRDEQDKQL SAERGEAAEN DYEEDFQGSD
DEDNEGDSKK ESAKDAGREK ASKDVQNHHR QNHKSSTLKT QELSIKFGTM RATKTNRLST
QQFADHPEKR TPVAFEILAS EIAYMHILKS INDVYVRPLK SALSSKRPIT GAQNIQIIFT
DIMNIYQLSR TLTEDLQNRL ADWNPQHTCL GDIFIKFCMH IKVYTNFTNN YEVILRCIER
CKEQSPAFRA FLERHERVPE TKMLTLQEIL LLPVIRIGEY VKLLTWFELH TPRTQADRQD
LDNAIATLTE LDRGIRECRT RMEREKELVQ LTRKIINCPA LLEANRYLVK HLDVAHLRPP
SSDTVVPELR VFQRIATLGL YLFNDALVIT RRTSKHFPFS RAVEYTYKFD LSVALTALQV
VDIPDSKYMA ACSVDLMQLQ LIELCRRKAY CGRTLTCLMI GLGCSDHPEM CQPACQERLQ
DDDSKARVGL QRRDSRAEVQ LGRHLGADSA RSFEPEVSLP RPRRLQGAIC FPETANKHSV
SRWWGCKEAG YNHEDDTFKA HFPWH
//
