ID A0A2T7P8J8_POMCA Unreviewed; 2074 AA.
AC A0A2T7P8J8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=RING-type E3 ubiquitin transferase BRCA1 {ECO:0000256|ARBA:ARBA00031556};
GN ORFNames=C0Q70_09001 {ECO:0000313|EMBL:PVD29745.1};
OS Pomacea canaliculata (Golden apple snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Architaenioglossa; Ampullarioidea; Ampullariidae; Pomacea.
OX NCBI_TaxID=400727 {ECO:0000313|EMBL:PVD29745.1, ECO:0000313|Proteomes:UP000245119};
RN [1] {ECO:0000313|EMBL:PVD29745.1, ECO:0000313|Proteomes:UP000245119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SZHN2017 {ECO:0000313|EMBL:PVD29745.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PVD29745.1};
RA Liu C., Liu B., Ren Y., Zhang Y., Wang H., Li S., Jiang F., Yin L.,
RA Zhang G., Qian W., Fan W.;
RT "The genome of golden apple snail Pomacea canaliculata provides insight
RT into stress tolerance and invasive adaptation.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVD29745.1}.
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DR EMBL; PZQS01000005; PVD29745.1; -; Genomic_DNA.
DR STRING; 400727.A0A2T7P8J8; -.
DR EnsemblMetazoa; XM_025239836.1; XP_025095621.1; LOC112564770.
DR Proteomes; UP000245119; Miscellaneous, Linkage group lg5.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR031099; BRCA1-associated.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR13763:SF0; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR13763; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1; 1.
DR Pfam; PF00533; BRCT; 2.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00292; BRCT; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000245119};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 19..59
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 1853..1940
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 1959..2064
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 118..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 932..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1026..1047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1205..1231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1396..1420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1569..1595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1625..1645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1806..1837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1516..1543
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 122..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..506
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..868
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..951
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1207..1231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1814..1837
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2074 AA; 229264 MW; 136403E53E2041CE CRC64;
MANPKIQEIL GLMQKNLECS ICLELLRNPV VTSCHHHFCK FCITEFLMTK RCVPCPLCKQ
PVSKRSLQDK AELNNIVTSI RSLISAFQED AGCTFSPPKG PQSFFPCTPE IITKKSRLRK
TKVKESRSER HSDQPQKEDI CSLLDDDKDT TVRVLSLLDM LRQTGVGKTK SIDSKEQSSD
AVETRSLTDV SKASAMRCVM VHDILEKENI GSVTTGSKRK KRGKDHTAKA GLLGYPNSAQ
VEKSSQNSSD QSVSSTQQFL QPRPPVTRTY SRRLSRVSSN CKKYGDGESS IIDQVPVNAK
EPDALPENSV DKPEPVLVGG HVHDFPLQSL SRSIVAQEVS ESPTSVPDFS LPPTEGGSNK
AMGDTSGEKK KKVAEKKEKM QYGGEDRSQI KEQIEKLASQ IDRAEDHTLL FSTQEACASM
ESTEHNVDDG DIENDVEGDH LAVVEPLCEV KTSFSEHSED QQRDNNALRE PDLSFDTQKS
NASDSKRKDT AKRSGKTEKE ALSSVTDTDS RDSSVNTAIC DTGGMALATQ QSYENSLCSI
VFPSPVAAML LPKFSSPRLH TARQNRGLTS TVSPKTSRLR GPAVGRRNGG SPQEEKVEFD
SLLTEKGKAQ SCSLNPCTPL TATRHSQARL SAEEAGHVPV KNKDGTVCFE QETSVLNNQK
DGMEAEHLEC PEMHRSHDER ADLLPDAQKL LVSELNSLED SSAPCSSVCV TDSLSVTDRQ
ELVDVNQGTD KNMEEEKVDQ RSKDCHALDD KRQTSINPVA IGIEYVNTKE TEMTEDSIVT
CIAESFEIEE HKAADSANKI SEVHVAVFEK SQNSEHLQNF NTDLQDRKNK GGGLEMVSVI
SQSPLQETLS SFSSENTDPS QSILQPPQAL GTKPGGMSAC RVKENAANRQ VSDNATTISL
NNNTANKQLS HLCADRQKSC DDKDPTVLKY KLHGSDPETT ERKKMRSGHC GKDGSPHSLL
ETRPLKETSN SLSTALQASD IDEMSLVLPA YNRKRKLSEA DNLDQTLAER IDAPLKQRLA
RKVLESPLTS QSGKSVHSAP SLVTKISSDS DEDTSLIIRR PKRKCFSLEG SPLTSKTPLA
TRRYKSRHAR RALSKSFCLD SEHDEINMGK PGVKERNSVV QTDYENKIVT DSDLEACAAD
SDMKMGEANV ADCSEKCVNV CSASSNLTVE FIIGKAVEST SVLSGECKDV LANSDKTPIL
IGEESITTKT TEKKDNNGAE KEDHSLSCTN DKPKCRRRTK RGLATVENAD ITMSLVRGFK
SPVANQCGTN SDCVAYRSPG NIASFKPNIL EQEISFSVEK VAEPTAASKK YNSLNNLSYI
DNLQVEDNEE SLYSIDKVVK AACEPSVNTE QYINDLQNSF SRKEASLKTV NNASIPPADF
DLGYSNLDGE MLDLNDKHTN DEENDKISGD SFTPESQRYK GDQGISHLEV QQTQTEKSEE
ETFTLTVQRK CPVATESYGE SDDDEVVCVK KRKHFALLSD SDSQSSDEYS NEEELSCQLS
SSALSSQSEI LTTQQQQALE ADLDQLRQKI AREEAKLHML QHDDLLTPDI CTQSLKSLSD
GQRLLESCAP LQDSSMQPDV VQEPKESEDE KEDENVVDRN LVWEPVLSPQ PHASLCEQSN
EIVDSNDESN ELFPSPLSPS PPPIIKPSLA RKDTAILSRS IFDMDVSEVR SLTKMTKFRQ
LEFVSDRAVD IPLKKSDEDM YADIQDSQDS EVLVTKASRI TPESQASIPP KAETLKCQHS
SPSFQETLAS IQSGQTVQFL PKSPSPVEIL PHLSDVCIQD RKNTPTSVKV ADSHCSVLSL
EGNECDELER DENSSSSDDS LPDSKEENKG EDDVHHCHSF EDEPKWKRKS MGFVASGLTP
EKLSLLRNLA ENYECKVYAK FNDCVTHVIM KAHDDPAIRI CERTLKYFQG VAGRCWVLSF
AWVQDCLSKG HLLPEADYEI EGDTVKGEAH FGPRISRLAT KPLLKGFSFA CVGSSPDMTK
KEMRQLLQMS GAEVVEDPWY LAKHPAKDKL VLRCIDSEAQ PVTPAETELF NGQYKHNKVV
TVKREWLLDS IGTQQLQPLK FYICITGKNL KLPF
//
