ID A0A2T7PE60_POMCA Unreviewed; 606 AA.
AC A0A2T7PE60;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Rabphilin {ECO:0008006|Google:ProtNLM};
GN ORFNames=C0Q70_07131 {ECO:0000313|EMBL:PVD31713.1};
OS Pomacea canaliculata (Golden apple snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Architaenioglossa; Ampullarioidea; Ampullariidae; Pomacea.
OX NCBI_TaxID=400727 {ECO:0000313|EMBL:PVD31713.1, ECO:0000313|Proteomes:UP000245119};
RN [1] {ECO:0000313|EMBL:PVD31713.1, ECO:0000313|Proteomes:UP000245119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SZHN2017 {ECO:0000313|EMBL:PVD31713.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PVD31713.1};
RA Liu C., Liu B., Ren Y., Zhang Y., Wang H., Li S., Jiang F., Yin L.,
RA Zhang G., Qian W., Fan W.;
RT "The genome of golden apple snail Pomacea canaliculata provides insight
RT into stress tolerance and invasive adaptation.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVD31713.1}.
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DR EMBL; PZQS01000004; PVD31713.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T7PE60; -.
DR STRING; 400727.A0A2T7PE60; -.
DR EnsemblMetazoa; XM_025236366.1; XP_025092151.1; LOC112562831.
DR Proteomes; UP000245119; Miscellaneous, Linkage group lg4.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd04035; C2A_Rabphilin_Doc2; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR043566; Rabphilin/DOC2/Noc2.
DR InterPro; IPR047022; Rabphilin_Doc2_C2A.
DR InterPro; IPR001565; Synaptotagmin.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45729; RABPHILIN, ISOFORM A; 1.
DR PANTHER; PTHR45729:SF6; RABPHILIN-1; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF02318; FYVE_2; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR PRINTS; PR00399; SYNAPTOTAGMN.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50916; RABBD; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000245119};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 41..158
FT /note="RabBD"
FT /evidence="ECO:0000259|PROSITE:PS50916"
FT DOMAIN 89..146
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 361..482
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 499..606
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 170..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..245
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 606 AA; 68104 MW; 51D17E14F5EEF864 CRC64;
MGEFGSSGSL DRWVCPNDRQ LALRAKLGTG WSVHTNRLAS FQRGENLSLE EQEQIMRVIN
RAEYIDHVEQ ERIGRLVEKL DNMKKNAIGN GSTQCILCGD EFGLLGASPT YCDDCKKAVC
SKCGVDTFSS ARQPLWLCKI CAETREVWKR SGAWFFKGLP KYTLPEKKLE GGKHSTRMKP
QLRGSVRGRP GSIRDSNYTW HRARGSSSTG TASYGESSEQ ESSDSSEDEI SISRHKSRKN
HESESDNISI GSARSSHYDH YTRTERKASV TSTSYGGGHV SATESSRGDD LHDETDSERS
STYQFSRDGS HMSQEHFTPA VGEEHAEDID RAVNRYVKST KPANDECDEA QVSSPESDGT
SLGSLEFSLL YDSANNALHC TIARAKNLKA MDSNGLSDPY VKLHLLPGAN KSTKLRTKTI
HKTLNPEWNE SLTYYGITED DVLKKTLRLS VLDEDAFGFD FIGETRVPLK RLKPHQTKHF
NVHLEKQLPL EKDDDLIAIR GKILLSLKYA TAKQSLLVRI IRCAELAAMD SNGYSDPYVK
VYLKPDKDKK SKFKTTVKKR TLNPEYNEEF TYDIKHNELA KKTLEITVWD KDIGKANDFI
GVTRSH
//
