ID A0A2T7PEV8_POMCA Unreviewed; 1149 AA.
AC A0A2T7PEV8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=G-protein coupled receptors family 1 profile domain-containing protein {ECO:0000259|PROSITE:PS50262};
GN ORFNames=C0Q70_07378 {ECO:0000313|EMBL:PVD31952.1};
OS Pomacea canaliculata (Golden apple snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Architaenioglossa; Ampullarioidea; Ampullariidae; Pomacea.
OX NCBI_TaxID=400727 {ECO:0000313|EMBL:PVD31952.1, ECO:0000313|Proteomes:UP000245119};
RN [1] {ECO:0000313|EMBL:PVD31952.1, ECO:0000313|Proteomes:UP000245119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SZHN2017 {ECO:0000313|EMBL:PVD31952.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PVD31952.1};
RA Liu C., Liu B., Ren Y., Zhang Y., Wang H., Li S., Jiang F., Yin L.,
RA Zhang G., Qian W., Fan W.;
RT "The genome of golden apple snail Pomacea canaliculata provides insight
RT into stress tolerance and invasive adaptation.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVD31952.1}.
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DR EMBL; PZQS01000004; PVD31952.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T7PEV8; -.
DR STRING; 400727.A0A2T7PEV8; -.
DR Proteomes; UP000245119; Miscellaneous, Linkage group lg4.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15137; 7tmA_Relaxin_R; 1.
DR CDD; cd00112; LDLa; 9.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 11.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24372; GLYCOPROTEIN HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24372:SF77; GPR INSULIN LIKE RECEPTOR 1; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF00057; Ldl_recept_a; 6.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 12.
DR SMART; SM00369; LRR_TYP; 6.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 9.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS01209; LDLRA_1; 5.
DR PROSITE; PS50068; LDLRA_2; 10.
DR PROSITE; PS51450; LRR; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000245119};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 802..825
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 837..860
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 926..946
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 976..1001
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1022..1043
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1055..1083
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 818..1074
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT DISULFID 111..123
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 118..136
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 130..145
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 150..162
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 157..175
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 169..184
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 189..201
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 196..214
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 266..278
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 273..291
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 367..385
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 379..394
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 401..413
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 408..426
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 420..435
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 440..452
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 447..465
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 459..474
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 482..494
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 526..538
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 533..551
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1149 AA; 129543 MW; 7E9425505A4A405B CRC64;
MSLTFNCLDV CGGVLASPPQ TSTNLNKLHL VEAVDRTCLP DSRQQLRKWA DGTFTNGEVV
EDEDATKSLC AEDWSFKCDE SMQECIDPKF LCNGVSECLN GRDESVEQCG CLPNEFQCNR
SHCIDVIKRC DLTDDCQDGS DERNCETYLC PLTHVKCTNH FCVPRDLMCD YVDDCGDNSD
EAQCEPRECA QTEFRCNNSE CVSMNYICDG QPDCKDHSDE LPESCERNFK CPTGLYILQS
LVCDGWEDCV FTHADEFHCE LLQNLCRSDE FRCNSSRCIS RNAVCDGVCD CINTCEDENG
CRNYGCKLGE GYLCRTTHRC LAPDLVCDGH NDCKNTQNGM DEHFCQTGKT NCNGLPVAEF
GENPLLCDSG QCVPDSTLCD HYMDCLDGKD EENCDSTFKP CEENQFQCSN KQCIHKSARC
DGKPDCIDRT DEVDCGDEPC PQHTRRCGGG QCVSETKWCD FERDCPDGSD EMSCRPEMHP
QCTASQFRCS SGQCVDQDVV CYDGKAAKNR GCKDNSHLIN CTTHSCKEGQ FKCRRSYCVD
SGQRCDGVVD CLMAAWDEHG CAFKCPYYSP VCICEGEDIH CENKQLTTLP HIERKAEPFS
NHFSGNRLEL TADTFVGLDR MTYLDLSNNS LESIPDGCFQ KLWRLVYLNL KNNKLHILTN
GTFQGLSNLR TLFLEGNEIG TIVPHAFVGL ASLTSLDLSK HRLSKIPQNA FVGLRNLHVL
SLSQNLIDTI ANGAFNGLDN LLSLDLSQNV IVLVEKNVFH GMGKLDTLYT DGFWFCCLAG
RVPHCYPEPD EFSSCEDLMS NYVLRVSIWV LGMVASFGNL LVIGWRARDM RCGKVHSFLI
TNLALGDFFM GVYLLIIAVV DSYYRGVYII YDRSWRTSDL CRFSGFISTF SSELSVFTLT
VITLDRLVCI IFPLKLKRLG LKQATIVMLM VWLAVFIVSI LPLLGFDYFR EFYGRSGVCL
ALHVTPDRPP GWEYSVAIFL VLNFASFLLI FFSYLWMFFI AKRTRSAVRS SESKNDSAMA
RRMTLIVMTD FCCWVPIILL GFASLGGARS SNEVYAWIAV FVLPLNSAIN PILYTISTAP
FLGNVRKRAS RFRKSFISSF TMDNTKHSYV DDRTTNSYYD RKSPYRQMDL IRMRSLNRSP
LNSHSESDI
//
