ID A0A2T7PK21_POMCA Unreviewed; 1062 AA.
AC A0A2T7PK21;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Transcription elongation factor SPT5 {ECO:0000256|ARBA:ARBA00020181, ECO:0000256|PIRNR:PIRNR036945};
GN ORFNames=C0Q70_04987 {ECO:0000313|EMBL:PVD33727.1};
OS Pomacea canaliculata (Golden apple snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Architaenioglossa; Ampullarioidea; Ampullariidae; Pomacea.
OX NCBI_TaxID=400727 {ECO:0000313|EMBL:PVD33727.1, ECO:0000313|Proteomes:UP000245119};
RN [1] {ECO:0000313|EMBL:PVD33727.1, ECO:0000313|Proteomes:UP000245119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SZHN2017 {ECO:0000313|EMBL:PVD33727.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PVD33727.1};
RA Liu C., Liu B., Ren Y., Zhang Y., Wang H., Li S., Jiang F., Yin L.,
RA Zhang G., Qian W., Fan W.;
RT "The genome of golden apple snail Pomacea canaliculata provides insight
RT into stress tolerance and invasive adaptation.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036945}.
CC -!- SIMILARITY: Belongs to the SPT5 family. {ECO:0000256|ARBA:ARBA00006956,
CC ECO:0000256|PIRNR:PIRNR036945}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVD33727.1}.
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DR EMBL; PZQS01000003; PVD33727.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T7PK21; -.
DR STRING; 400727.A0A2T7PK21; -.
DR EnsemblMetazoa; XM_025231482.1; XP_025087267.1; LOC112559962.
DR OrthoDB; 24955at2759; -.
DR Proteomes; UP000245119; Miscellaneous, Linkage group lg3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06082; KOW_Spt5_2; 1.
DR CDD; cd06083; KOW_Spt5_3; 1.
DR CDD; cd06084; KOW_Spt5_4; 1.
DR CDD; cd06085; KOW_Spt5_5; 1.
DR CDD; cd06086; KOW_Spt5_6; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR Gene3D; 2.30.30.30; -; 3.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041975; KOW_Spt5_2.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR041978; KOW_Spt5_5.
DR InterPro; IPR041980; KOW_Spt5_6.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR006645; NGN-like_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR024945; Spt5_C_dom.
DR InterPro; IPR022581; Spt5_N.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; SUPPRESSOR OF TY 5; 1.
DR PANTHER; PTHR11125:SF7; TRANSCRIPTION ELONGATION FACTOR SPT5; 1.
DR Pfam; PF00467; KOW; 3.
DR Pfam; PF03439; Spt5-NGN; 1.
DR Pfam; PF11942; Spt5_N; 1.
DR PIRSF; PIRSF036945; Spt5; 1.
DR SMART; SM01104; CTD; 1.
DR SMART; SM00739; KOW; 6.
DR SMART; SM00738; NGN; 1.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036945};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000245119};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR036945}.
FT DOMAIN 179..270
FT /note="NusG-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00738"
FT DOMAIN 275..302
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 423..450
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 475..502
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 597..624
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 706..733
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 769..917
FT /note="Spt5 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01104"
FT DOMAIN 1011..1038
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT REGION 1..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..67
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..105
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 812..838
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..905
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1062 AA; 116433 MW; B6D97672EBBE1543 CRC64;
MSDSEDSPFS DAESEGGDQN ESKNDGSDAG QEGSDAEDKP GDDDNEVDEE GGDDDEDEED
YDDEDEEEGI GRPKKKKRRG ALGFIIDEAD VDEEDEDDEE WEEGAEELID RKSTYEGPSA
KEIESHQRLN QILESQDEDE IEAYYRQRYG DSTAMDRFGD GEEMSDEITQ QGRLPGVKDP
NLWVVKCRMG EEKAVVVHLM RKMIAFQNTD EPLQIKSVVA KEGLKGYIYI EAYKQIHVKQ
AIEGIGNLRV GCYNQQMVPI REMTDVLKVV KETANLKPKT WVRLKRGIFR DDLAQVDYVE
PSQNVVHLKM IPRIDYTQPR GILRSSANQD QGKKRKRRPP QKLLDVDAVR SIGGEVSTDG
DFVIFEGNRY NRKGFLFKSF AMSAIVSEGI KPTLVELEKF EEQPEGIDVE LAPEKASGEI
VHNLAPGDVV EVAEGELINL QGKVIKVDGN KITFLPNHKD LKNPLEFPAN ELRKFFKMGD
HVKVIRGRYE GDTGLIVRVE EKMIVLFSDL TMHELKVLPK DIQLCTDMAT GVDSLGQFQF
GDLVQLDPQT VGVIVRLEKE NFQVLNMHNK VVSVKPQSIT RKKDTRHAVA LDSENNNIQV
KDVVKVIDGP HSGRQGEIMH LYRSFAFLMS RMMTENGGYF VCRTRHLVLA GSSRQNLAAP
MGGMAPMSPR LSSPAHPSSG GGGGGGGGGG AGSAGRGRGG MTRRDRELIG QTVRIKQGPF
KGYIGIVKDA TEDTARVELH SSCKTISVDK SRLLTLTGPR AGTATSTYGG RTPVYGGQTP
MYGSRTPMYG SQTPLHDGSR TPHYGGQTPL HDAGSRTPSG GNSAWDPSSA NTPSRNNDFD
YPYEEASPTD YATTPNPATP GYQADAPSPV GPYTPQTPGS TYSPYHPTTT SPATFQANSP
GYVGTPSPAG YQPSPSPGGY AGTPSPAGIG FSPMTPGAPF TPQTPGTAMD HNLSDWHTTD
ILVKVKETHD DPDLIYQTGV IRSISGGMCS VYIMENDKVV NIACEHLEPV APTKHEKAKV
ILGDERETVG TVLSIDGCDA VFKIDEKNIR MLPVKHLCRM QS
//
