ID A0A2T7PLG4_POMCA Unreviewed; 930 AA.
AC A0A2T7PLG4;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN ORFNames=C0Q70_05540 {ECO:0000313|EMBL:PVD34271.1};
OS Pomacea canaliculata (Golden apple snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Architaenioglossa; Ampullarioidea; Ampullariidae; Pomacea.
OX NCBI_TaxID=400727 {ECO:0000313|EMBL:PVD34271.1, ECO:0000313|Proteomes:UP000245119};
RN [1] {ECO:0000313|EMBL:PVD34271.1, ECO:0000313|Proteomes:UP000245119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SZHN2017 {ECO:0000313|EMBL:PVD34271.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PVD34271.1};
RA Liu C., Liu B., Ren Y., Zhang Y., Wang H., Li S., Jiang F., Yin L.,
RA Zhang G., Qian W., Fan W.;
RT "The genome of golden apple snail Pomacea canaliculata provides insight
RT into stress tolerance and invasive adaptation.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVD34271.1}.
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DR EMBL; PZQS01000003; PVD34271.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T7PLG4; -.
DR STRING; 400727.A0A2T7PLG4; -.
DR Proteomes; UP000245119; Miscellaneous, Linkage group lg3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245119};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 716..741
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 770..920
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 21..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 930 AA; 104810 MW; FD24335A27AE72B5 CRC64;
MSAAPKSEVV KIFQISPFDT ANLSQSSSPL TPKVSETNRE NSKHSSLTSS SQNDANNGSF
TVSLLQNPKS IPRDASKDFI ENWNLSDDIL TPFSSGEERK DKITLGRGGP FCTRVEEINT
EEGQGILQES LGNLVNDESY RNDNEDQTVD KDDEDSKVGS HDNNGENNDE DSFRRKRFDS
IEAPEDYFRD QAMGQQKDNS NGFTSNLMTS AGLAASWPES GITTAQPVSQ DIPCDDFVCD
CSKKKKQASC CGRQYKLRHI PRVPAYVTTF RLWMASLGEL TKEKLGNLSN YHIKTMDLQN
NRIMILDNDT FVLFTHLESL DLGSNPISAV MLRDAFYSIG SSKFVALRLD SMFIYDLPDN
FFDAFQNKSF DIISIANNSL TTFNARTFSP FRSVIRLILS DNSIYSFVLN NTVYAKKLHL
ERNVLTSLPL LCSSNGGLVF PNLFSLYLGG NPFKSVSAGI LRGLCLPKLH KLDISSSIVL
KSLGNNFVAD LPMLVNLMAG NMASLSRYEP FCFNSSSLEK LFLKGNKVWD YGTIVPGEIF
AHAPNLKTVD MTKIKFNLNT EVDLARMLLP AKSLVTLNME ACLLGSLPAD TFSQLPNLRT
LDFIGNHISA FSLAPAFRNV TRLDTLILQA NQITIVNEST FPLEFRRSIR VLDLSKNDFA
CTCDLLWFKS WIEQERKSGN ISFPDYPKYY RCRTPDNLRG QYISDYNPSY RDCHPLSIYV
VVGSAVGAVV LVTALTLSLA YRYRWYLRYY VYRLRRRRQY KPIVDEDDGI VYDIYIAYSQ
FDVEWVAQEL APLLEASPDV KVSTIKRGAD KETCTSMHLQ TDTILHIADN IVQYMDQSSR
IVLVLSDGYA REGWSGYEFN NVIYAANEQH KDVIVILKGD IEAGRLTKDM RRLLTGGTFL
HWEETEEAMG MFKDALNVAL RTRGNLQELV
//
