ID A0A2T7PMP9_POMCA Unreviewed; 649 AA.
AC A0A2T7PMP9;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Sodium-dependent nutrient amino acid transporter 1 {ECO:0000256|ARBA:ARBA00040215};
GN ORFNames=C0Q70_05966 {ECO:0000313|EMBL:PVD34689.1};
OS Pomacea canaliculata (Golden apple snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Architaenioglossa; Ampullarioidea; Ampullariidae; Pomacea.
OX NCBI_TaxID=400727 {ECO:0000313|EMBL:PVD34689.1, ECO:0000313|Proteomes:UP000245119};
RN [1] {ECO:0000313|EMBL:PVD34689.1, ECO:0000313|Proteomes:UP000245119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SZHN2017 {ECO:0000313|EMBL:PVD34689.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PVD34689.1};
RA Liu C., Liu B., Ren Y., Zhang Y., Wang H., Li S., Jiang F., Yin L.,
RA Zhang G., Qian W., Fan W.;
RT "The genome of golden apple snail Pomacea canaliculata provides insight
RT into stress tolerance and invasive adaptation.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium
CC cotransporter that promotes absorption of the D isomers of essential
CC amino acids. Neutral amino acids are the preferred substrates,
CC especially methionine and phenylalanine.
CC {ECO:0000256|ARBA:ARBA00037785}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVD34689.1}.
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DR EMBL; PZQS01000003; PVD34689.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T7PMP9; -.
DR STRING; 400727.A0A2T7PMP9; -.
DR EnsemblMetazoa; XM_025230499.1; XP_025086284.1; LOC112559343.
DR Proteomes; UP000245119; Miscellaneous, Linkage group lg3.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616:SF241; SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 4: Predicted;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245119};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 108..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 455..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 26..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 649 AA; 70473 MW; 7001304FAC828F21 CRC64;
MTRPVHASSD VVVVLQRLLA APMSAHTPSE RELQGSSTVL VQPGYDGGGS QGEVGDVEGP
KHPMVLEVEE EERGPLRSRL EFLLLCLSLA IGTRTVVQYP VLAMRHGGGA FTFVYLVLTA
VLGSSLGVHG DGSGAVCTRR AYISVGYNTS LQSMEQVNIT IHQLSALLAE DTTTPVADDN
TTTYAYSVNF NFSDPTTVTP VYTSGHNHSL VTIIAGFYRC HYAQKFFYES VLGLTSGLGD
SGELQVYLSL CLMLVWIVTG LTVAWGPLSM SRVSYVSSTA PVMLLMVLLG AVCSTDGSVR
GLRAFLTPRW TQLARVQMWW DGAKLVLTGS VCGTGAIISL SAWANFHSNC FRNSVIITTV
AVLTTLLGGC TLFAALGGHL FLELTDVKHL HLSDVDLMFA LLPSLTAYLP CPPLWCILWF
GLLVVGSMGV QGALLHNLHS GVVSLARASH RQAALFLLAV LVLLLFLLSL STVTQGGLYV
VQFLERAVYL LAVPAVCLAE VLTLMWLYGV QRLANRISDM TGKSESFLWK WMWKFLCPTV
LTVSSCSLAT RRVFHPACMR AYVCTSASYM FVCVSSGMQR CSFSASLLKA LGTTPRAWGP
RHHEHEPQLE LPDYVICSPD VYRPANALAL LTANLYLPNL SNFLSIQQL
//
