ID A0A2T7TJJ7_9MICC Unreviewed; 764 AA.
AC A0A2T7TJJ7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=DDA93_10580 {ECO:0000313|EMBL:PVE17429.1};
OS Arthrobacter sp. Bz4.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=2171979 {ECO:0000313|EMBL:PVE17429.1, ECO:0000313|Proteomes:UP000244710};
RN [1] {ECO:0000313|EMBL:PVE17429.1, ECO:0000313|Proteomes:UP000244710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bz4 {ECO:0000313|EMBL:PVE17429.1,
RC ECO:0000313|Proteomes:UP000244710};
RA Goncharov A., Nikolskiy P., Shidlovsky F., Kolodzhieva V., Zueva L.,
RA Masharskiy A., Suvorov A.;
RT "Putative ancient Arthrobacter sp. strain from the intact mummy of late
RT pleistocene steppe bison (Bison priscus bojanus).";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVE17429.1}.
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DR EMBL; QDAE01000012; PVE17429.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T7TJJ7; -.
DR OrthoDB; 9766909at2; -.
DR Proteomes; UP000244710; Unassembled WGS sequence.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000244710};
KW Transferase {ECO:0000313|EMBL:PVE17429.1}.
FT DOMAIN 77..263
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 367..646
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 717..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 764 AA; 80946 MW; 6D63FC65AE20CDEE CRC64;
MAARKSPIFD TATTLGKMIA FLGISALSGV LAAGLLVPVA AATGTGASAS IQFFEELPAE
LERGALAQPS RILASDGTLI ATLYEENRQP VTLDQVSPNM VNALLAIEDA RFYEHGGVDL
QGIMSAVVSN VSSDTTRGAS TITQQYVNNV LIDASLQSGD GSVTFSGGKT LGDKLREAKL
AIAVEKELSK DEILEGYMNI VPFTGTTYGV QAASRYFFNV EAADLNIQQA ALLAGVVNGP
TFYSPELNPE RSLERRNLVL GAMLSNSHIT QEEYDAAVAT DLGLDITPTL SGCVGAEQAP
YFCDYVTHLI LNDPAYGESL EARQDTLYRA GLTITTTLDP VAQTAAQTAI NETAGRETTD
PSVGHSMVSM EPGTGDILVM AQNTRYMPGT EPGDSVLNFN VDQYSGGDPN QPLGGVGGFQ
PGSTFKPFIV AAWLEDGRAL NTTIDGRKRI YPQFDEWEAS CYPDGKYVLP DEDGYEPQNY
GDINYGSYTV LEGLAQSYNT ITMETARQID LCMPFQIAAD LGIHDGKSAD GDYTPLTVSP
SALIGGGSEV SPISMATAYA ALGAEGMTCE PRALTEVVAV DGTSFPVPEA ACEQAIPEEL
ARGVNYATEA VMERGSGQLL EFGDIPMAGK TGTNDARSQT WFMGYNSGMA TATWLGNWKA
NSVSLGELQI GGQIYPEIDG SFIAAPSWER FMQQIPGLHS GEPFTDPPQR MLNAQRPTIQ
TQPGNGNQTG RPGDNQGSPG NSGPPADPPP GNSPEDPDNN EDEG
//
