ID A0A2T7TME8_9MICC Unreviewed; 1086 AA.
AC A0A2T7TME8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=DDA93_05145 {ECO:0000313|EMBL:PVE19196.1};
OS Arthrobacter sp. Bz4.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=2171979 {ECO:0000313|EMBL:PVE19196.1, ECO:0000313|Proteomes:UP000244710};
RN [1] {ECO:0000313|EMBL:PVE19196.1, ECO:0000313|Proteomes:UP000244710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bz4 {ECO:0000313|EMBL:PVE19196.1,
RC ECO:0000313|Proteomes:UP000244710};
RA Goncharov A., Nikolskiy P., Shidlovsky F., Kolodzhieva V., Zueva L.,
RA Masharskiy A., Suvorov A.;
RT "Putative ancient Arthrobacter sp. strain from the intact mummy of late
RT pleistocene steppe bison (Bison priscus bojanus).";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVE19196.1}.
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DR EMBL; QDAE01000004; PVE19196.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T7TME8; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000244710; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.800; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF23; RECBCD ENZYME SUBUNIT RECB; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000244710}.
FT DOMAIN 8..438
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 461..753
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 29..36
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1086 AA; 119125 MW; 63A2645A13EF1A8C CRC64;
MNLDVLDLAD QSDRTLIKEE RLVNIFVEAG AGSGKTHELV ERILALVDNR VELKNIAAIT
FTEKAAGELR ARVRRRLAED KTPIREVALA QLDTAPIGTI HSFAARIISE HPIEAGVPPL
ITVVDELRSQ IAFTRRWELI RQQLFSDPTL DDALRVLLAV GASLNHLETL ASALDANWDR
LESHPPQRRP IPAADLGPLL RQTAEVLDHT QHCSDADDLL LVALEKVRSW HGRLQNAGTG
ELVMVLEILD DIPLTPKQGK KGNWAIDITA VRDACAKLGE AANALRDSFV APAVDTVTAA
MAELFVEAAR ERQRSGELEY NDLLIHARDL LVGTGQRTTD VHRALRERYR CIMLDEFQDT
DPVQAEIATR ITATTVCGVD DWQSLVIPAG RLFTVGDPKQ SIYRFRRADI ATYLDTQRRF
ERNEHSRIAS LRTNFRSTDA LLDWINTSFS QLIQANGNVQ PPYQLLTADP ARPAWDDTDG
PAVSIIGREG AVAGESGKVS ADEMRKQEAA DVAAAILLAT GRSGEPAWLK QAKRSEGFAT
TPLRLKDVTI LLPTRTALTA LEDALDDASV EYRAEASSLV YSTQEVNDLL LALKAVANTA
DTAALVLCLR SAPFGCGDDE LFEWKTSGGS WNLFAPAPAG LESSPVAQGI EYLSELCRQI
SVLTPAELMD TLVTERRMME TAIDSPRYRD VWRRLRFVID QARAWSEATH GSLRDYLVWA
GTQQEENTRV REAVVPETDV DAVRIMTIHA SKGLEFPMVI LAGTGSAPRT SYDAALWDAD
GTLHVSFVKG ITSAGYGDAQ SVERQFNEAE RCRLLYVACT RAESHLVLSY YTNSRSSLGQ
LLQNVDDPAV PSLELPPPSE SVARRHTDVQ PVQPWDEWNR QRAEWQASSA IVSTTSVTAL
AKGTADGGPI EGELQFLPLD DETLPSPAPA NAERGAEFGT ALHRVMELSD LQESADVEAI
AGSVALLAHG VTAPALAARA RAALSSEPVR RAAQREHWLE LPVVVPRGGV TVEGVIDLMY
REDDGTLVIA DFKTDSTPQE ETIAAYWRQL STYADMVQGI TGQSVSRLAL IFCRDAGAEV
MYREAR
//
