ID A0A2T7UVW9_9RHOB Unreviewed; 692 AA.
AC A0A2T7UVW9;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=DNA polymerase III subunit epsilon {ECO:0000313|EMBL:PVE48784.1};
GN ORFNames=DDE23_04175 {ECO:0000313|EMBL:PVE48784.1};
OS Pararhodobacter aggregans.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Pararhodobacter.
OX NCBI_TaxID=404875 {ECO:0000313|EMBL:PVE48784.1, ECO:0000313|Proteomes:UP000244810};
RN [1] {ECO:0000313|EMBL:PVE48784.1, ECO:0000313|Proteomes:UP000244810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D1-19 {ECO:0000313|EMBL:PVE48784.1,
RC ECO:0000313|Proteomes:UP000244810};
RX PubMed=21959289; DOI=10.1016/j.syapm.2011.08.006;
RA Foesel B.U., Drake H.L., Schramm A.;
RT "Defluviimonas denitrificans gen. nov., sp. nov., and Pararhodobacter
RT aggregans gen. nov., sp. nov., non-phototrophic Rhodobacteraceae from the
RT biofilter of a marine aquaculture.";
RL Syst. Appl. Microbiol. 34:498-502(2011).
CC -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC responsible for most of the replicative synthesis in bacteria. The
CC epsilon subunit contain the editing function and is a proofreading 3'-
CC 5' exonuclease. {ECO:0000256|ARBA:ARBA00025483}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVE48784.1}.
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DR EMBL; QDDR01000002; PVE48784.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T7UVW9; -.
DR OrthoDB; 9804290at2; -.
DR Proteomes; UP000244810; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProt.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd06127; DEDDh; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006054; DnaQ.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR NCBIfam; TIGR00573; dnaq; 1.
DR PANTHER; PTHR30231; DNA POLYMERASE III SUBUNIT EPSILON; 1.
DR PANTHER; PTHR30231:SF4; PROTEIN NEN2; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000244810};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 498..667
FT /note="Exonuclease"
FT /evidence="ECO:0000259|SMART:SM00479"
SQ SEQUENCE 692 AA; 74022 MW; B67ED69088164A39 CRC64;
MLDRLSLRLR ILLFFALLAG GALLAMAAGL AVAGRHGGLT PEAVQGALVA GFAILGLVVW
VWFLFDHNVA RAIDTLAAAI RARAHAGIER DLAAEAKAAR YLGDLAPAAE AVTRSLVETR
NALAESVARE TTRLAAEKSR LETLLADVPV AVLLCSAEHQ LAFYNGQAVD ILGGGTAPGL
DRNLLDYLRE GPIRHAYDRL AGAGDPDAAS DLLCATVTGA RLLAGRMRVL RRREEGVAPG
YVLTLRDVTA DIAAHTSRDA LLSEVFDRVR RPAANLQTVI GVLSELEGAE DAPDLSAAMR
AEIEALTLAI TELGARYDAI QTDWRPLMNT RSGDLLDGLK GRFQADGFSL ETESLDLILQ
VDGFEIVAFW AWLAGRIAGE GLATAFRIVI EEEDGPGAVM RLCWQGEPLS VGRLDGWLPG
AMGRDTGELT ARAVLQTHGT EAWPEAGEGC NAVVMPIRSV RRAGRRVAPL SRKVVYDFDL
LSKARNAAVA DTRLEDLTLV VFDTETTGLS PSSDAVVQIA AVRLVNGKRV ESEVFDTLVD
PGRPIPPAST DVHGITDSMV VGAPDIAEAG RRFHKFAEGA VLVAHNAPFD MEFLRRQEGA
IGKVFDHPIL DTVLLSAVVY GQLEQHSLDA LTARLGITIP EEARHTAIGD TIATADAFLK
LVPMLKARGL TTFGQVVAEV RKHGRLLKDL NG
//
