ID A0A2T9Y1V4_9FUNG Unreviewed; 1187 AA.
AC A0A2T9Y1V4;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=DNA replication licensing factor MCM2 {ECO:0000256|ARBA:ARBA00018925};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=BB560_006758 {ECO:0000313|EMBL:PVU86321.1};
OS Smittium megazygosporum.
OC Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota; Kickxellomycotina;
OC Harpellomycetes; Harpellales; Legeriomycetaceae; Smittium.
OX NCBI_TaxID=133381 {ECO:0000313|EMBL:PVU86321.1, ECO:0000313|Proteomes:UP000245609};
RN [1] {ECO:0000313|EMBL:PVU86321.1, ECO:0000313|Proteomes:UP000245609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC-DP-2 {ECO:0000313|EMBL:PVU86321.1,
RC ECO:0000313|Proteomes:UP000245609};
RX PubMed=29764946;
RA Wang Y., Stata M., Wang W., Stajich J.E., White M.M., Moncalvo J.M.;
RT "Comparative Genomics Reveals the Core Gene Toolbox for the Fungus-Insect
RT Symbiosis.";
RL MBio 9:e00636-e00618(2018).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVU86321.1}.
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DR EMBL; MBFS01003505; PVU86321.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T9Y1V4; -.
DR STRING; 133381.A0A2T9Y1V4; -.
DR Proteomes; UP000245609; Unassembled WGS sequence.
DR GO; GO:0031261; C:DNA replication preinitiation complex; IEA:UniProt.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0005656; C:nuclear pre-replicative complex; IEA:UniProt.
DR GO; GO:0043596; C:nuclear replication fork; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR GO; GO:0006279; P:premeiotic DNA replication; IEA:UniProt.
DR CDD; cd17753; MCM2; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008045; MCM2.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF44; DNA REPLICATION LICENSING FACTOR MCM2; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF12619; MCM2_N; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01658; MCMPROTEIN2.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000245609};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 741..947
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 209..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..277
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1187 AA; 132598 MW; A7E583023BE93B0A CRC64;
MTAEKKAPLE TERSVVKDLL LRLSERIKKM DIIEFAMLCN ASEAINANQK YSKQTNTDLS
TSRSILGIEN SNEILGIARS QPNESTLVSS YNIKGPRTTE YSSSISDTKP EPPIQDQTQL
GKAICCSLDG NAPKNVLQGQ SPVSTTNSFQ EKACIEITEK TIAAEDLLLP GSHGKAQPLD
GISSTKQFKS FPNASRIKTK YIPGFGLADA ESKSVRSRPK NRKGNRKRTA ANDSDDSDKE
TSFPQTPGGG LSYLSSPPPF RGGMLPPSSP PPFSPFTPLY NREISDDEFE DALEEAREAD
IEEENNEEEE GEKIALEEDL SGEDLFDSDM EKDYREIDGL DDYENIDIDD ENVFNAMDPA
ERAKIEARLR RRDLEEGKLS TRSRIPAAFL QAMDDEEWTG RDIDLTKRRR RRFGADSNIH
AALLDGTLDI DDEEKALTLD DLKDMKGNSV SAWISEAGPR QAISREFRNF LLTYVDEKGN
SVYGERIRKL GEVNGESLEV NYPHLATSKP IIAYFLVNAP KEMFTIMDDI AMDAVLTVFP
DYARICPEIH VRVSGLPVVS SLRDLRQAQL DTLVRVSGVV SRRTSVFPQL KYVKFDCSKC
GAVLGPFYQD NKSEIKIGAC TNCQSRGPFS VNSENTVYRN YQRITLQETP GSVPAGRLPR
HREVILLWDL IDYAKPGEEI EVTGVYCHSY DASLNARQGF PVFTTVIEAN HLLKKSDEFS
AFKLTEEDRR ELRALSRSKD LERRLIKSIA PSIYGHTTLK HTLILSLFGG VPKDIGGKLR
TRGDINVLML GDPGTAKSQL LKYIESTAHR AVFTTGQGAS AVGLTASVRK DPVTREWTLE
GGALVLADRG VCLIDEFDKM NDADRTSIHE AMEQQSISIS KAGIVTSLQA RCSVLAAANP
IGGRYRPSLT FSQNVMLTEP ILSRFDVLAV VRDEVDPIKD ELLGKFVVKS HILSHPEFDA
LGPDAFSDTN LTQETQEMNG LEKLNELDIS DVDIIPQETL KKYIMYAREN ITPKFQKIDY
DKVTQLYSEL RKESLATGSI PITVRHVESI IRLSEAHARM HLRDNVRSDD LDVAIKITLT
SFISAQKLSV AKQLKRAFAK YLTASSDFDE LLYMILCKII QEKVTFYQFR NQGAFPPVVE
VEFEELESQA KSSQIYSFKS FYNSNLLKNQ GFVVNIQQKT ISKSFGV
//
