ID   A0A2T9Y7G6_9FUNG        Unreviewed;      1062 AA.
AC   A0A2T9Y7G6;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=U-box domain-containing protein {ECO:0000259|PROSITE:PS51698};
GN   ORFNames=BB560_006388 {ECO:0000313|EMBL:PVU88234.1};
OS   Smittium megazygosporum.
OC   Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota; Kickxellomycotina;
OC   Harpellomycetes; Harpellales; Legeriomycetaceae; Smittium.
OX   NCBI_TaxID=133381 {ECO:0000313|EMBL:PVU88234.1, ECO:0000313|Proteomes:UP000245609};
RN   [1] {ECO:0000313|EMBL:PVU88234.1, ECO:0000313|Proteomes:UP000245609}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC-DP-2 {ECO:0000313|EMBL:PVU88234.1,
RC   ECO:0000313|Proteomes:UP000245609};
RX   PubMed=29764946;
RA   Wang Y., Stata M., Wang W., Stajich J.E., White M.M., Moncalvo J.M.;
RT   "Comparative Genomics Reveals the Core Gene Toolbox for the Fungus-Insect
RT   Symbiosis.";
RL   MBio 9:e00636-e00618(2018).
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the ubiquitin conjugation factor E4 family.
CC       {ECO:0000256|ARBA:ARBA00007434}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PVU88234.1}.
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DR   EMBL; MBFS01003179; PVU88234.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2T9Y7G6; -.
DR   STRING; 133381.A0A2T9Y7G6; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000245609; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000151; C:ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0034450; F:ubiquitin-ubiquitin ligase activity; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:InterPro.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR019474; Ub_conjug_fac_E4_core.
DR   InterPro; IPR045132; UBE4.
DR   InterPro; IPR003613; Ubox_domain.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13931:SF2; UBIQUITIN CONJUGATION FACTOR E4 B; 1.
DR   PANTHER; PTHR13931; UBIQUITINATION FACTOR E4; 1.
DR   Pfam; PF04564; U-box; 1.
DR   Pfam; PF10408; Ufd2P_core; 1.
DR   SMART; SM00504; Ubox; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS51698; U_BOX; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245609}.
FT   DOMAIN          989..1062
FT                   /note="U-box"
FT                   /evidence="ECO:0000259|PROSITE:PS51698"
SQ   SEQUENCE   1062 AA;  119831 MW;  DEA590C701CCF582 CRC64;
     MAKKTIQDWE NSAFSKILSA TVSNSADTNL FYLSSTASEI KDSSSPLLLT SSFLESAILE
     CLDSDDFLSK HGNSLSFLLN SWKKTHEIYT NLKGPKGSAL DPEQREHRLT SLCHLEGLLI
     VYCGLSLQDD TLFSGKNASN FISLIKPSHS ELLGWFTQII KKFEDDGLEE IVENIISELN
     SQILEANDVL NKEAFELLKL FDFFVSIPAV SSCISKIPWF MSGEGKEVEK KSVFGPLFSI
     SAFPEEKNIR VVEFFSKTGS SSEENKKITM NTIRSSVSLF QSGLFKVINT FVRSSLFARG
     EFVKWVAKAI CSNIKRTGLQ VDPKAVASDG FFDNLTFVLL GLCAPFSSDP LLSKIDKIEL
     VAWPYVRVLS GYLDNEQPES SSGVVKTCWN DLTRLCASSE EIKQNEAAMA SKINMSTQIG
     FIPDCFFLTT LAIHVGPLAT ISKIGQLGKE IHQMQNQLDS IQSSIDNNQS SNPSSNILLE
     RWHNHLEKLK DIRVAFEAQS MDPKRLATLL SFSRFAIGAL LSLNQLATST EVWYWKSFPE
     YLLEDQLQLI LFVARYAPDA LMSPDLSPPH PGVKLLDDLV SALTISILSL PELVRNPYIK
     SRLVDVLHSL TYTPPENDDD CVDTLQGHQS AYSGDIYSQQ KRFVVHPIVS QFIGSLNEIQ
     ADNYIPNSFL KNIKTSFPLK DLVMVLLKLY IDIEHTSSNS AFYDKFSVRY NIARIMRSLW
     NQPQSQYLRA TYAFFVSSKT NSAEKNEIVD QFVSRLVSDT TYLLDESLSN LSKVKTLDSE
     IEKLNQEQPQ NINLLREKHS ELQQTERHAS VLVTLTHETV HVLAFLTRLV PVPFRSESII
     LRFAAMLNYN LDLLAGPKCR DLKVKNMKER FEFNPKILLS ELLSVYLHLG YSKSKIASSG
     GVKIQADDDY FIKGIDKIQE SIDIEKFIDA LAEDQRSWNS KIFRSSLELC MKLGLKPIQS
     VQLLFGLIDK VEKRVLKINS QASAELTEDV PEEFLDPIMY TLMENPVLLP TSQSICDYKT
     IKGYLLTDPR DPFNRKPLEI KDVVFLPELK AKIDAYKQSR KS
//