UniProt: A0A2T9YC54

Database: UniProt
Entry: A0A2T9YC54_9FUNG

LinkDB:  A0A2T9YC54_9FUNG 
Original site:  A0A2T9YC54_9FUNG

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Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (12)   
   InterPro (9)   
   Pfam (2)   
   PROSITE (1)   
Literature (1)   
   PubMed (1)   
All databases (18)   

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ID   A0A2T9YC54_9FUNG        Unreviewed;       791 AA.
AC   A0A2T9YC54;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   13-SEP-2023, entry version 18.
DE   RecName: Full=methionine--tRNA ligase {ECO:0000256|ARBA:ARBA00012838};
DE            EC=6.1.1.10 {ECO:0000256|ARBA:ARBA00012838};
DE   AltName: Full=Methionyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030904};
GN   ORFNames=BB559_004874 {ECO:0000313|EMBL:PVU89916.1};
OS   Furculomyces boomerangus.
OC   Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota; Kickxellomycotina;
OC   Harpellomycetes; Harpellales; Harpellaceae; Furculomyces.
OX   NCBI_TaxID=61424 {ECO:0000313|EMBL:PVU89916.1, ECO:0000313|Proteomes:UP000245699};
RN   [1] {ECO:0000313|EMBL:PVU89916.1, ECO:0000313|Proteomes:UP000245699}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AUS-77-4 {ECO:0000313|EMBL:PVU89916.1,
RC   ECO:0000313|Proteomes:UP000245699};
RX   PubMed=29764946;
RA   Wang Y., Stata M., Wang W., Stajich J.E., White M.M., Moncalvo J.M.;
RT   "Comparative Genomics Reveals the Core Gene Toolbox for the Fungus-Insect
RT   Symbiosis.";
RL   MBio 9:e00636-e00618(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-
CC         methionyl-tRNA(Met); Xref=Rhea:RHEA:13481, Rhea:RHEA-COMP:9667,
CC         Rhea:RHEA-COMP:9698, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:57844, ChEBI:CHEBI:78442, ChEBI:CHEBI:78530,
CC         ChEBI:CHEBI:456215; EC=6.1.1.10;
CC         Evidence={ECO:0000256|ARBA:ARBA00001234};
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363039}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PVU89916.1}.
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DR   EMBL; MBFT01000515; PVU89916.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2T9YC54; -.
DR   STRING; 61424.A0A2T9YC54; -.
DR   Proteomes; UP000245699; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006431; P:methionyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd07957; Anticodon_Ia_Met; 1.
DR   CDD; cd00814; MetRS_core; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 2.20.28.20; Methionyl-tRNA synthetase, Zn-domain; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR041872; Anticodon_Met.
DR   InterPro; IPR023458; Met-tRNA_ligase_1.
DR   InterPro; IPR014758; Met-tRNA_synth.
DR   InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR   InterPro; IPR033911; MetRS_core.
DR   InterPro; IPR029038; MetRS_Zn.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   NCBIfam; TIGR00398; metG; 1.
DR   PANTHER; PTHR45765; METHIONINE--TRNA LIGASE; 1.
DR   PANTHER; PTHR45765:SF1; METHIONINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR   Pfam; PF19303; Anticodon_3; 1.
DR   Pfam; PF09334; tRNA-synt_1g; 1.
DR   PRINTS; PR01041; TRNASYNTHMET.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF57770; Methionyl-tRNA synthetase (MetRS), Zn-domain; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363039};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363039};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363039};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245699}.
FT   DOMAIN          227..617
FT                   /note="Methionyl/Leucyl tRNA synthetase"
FT                   /evidence="ECO:0000259|Pfam:PF09334"
FT   DOMAIN          649..790
FT                   /note="Methionyl-tRNA synthetase anticodon-binding"
FT                   /evidence="ECO:0000259|Pfam:PF19303"
SQ   SEQUENCE   791 AA;  89326 MW;  55DDDDE9716D0815 CRC64;
     MDTTKNSTDF TFFLNGAPPA TGSLSAIGLL KIALAISINN LSIQTKSNKE IKSKLPFWMV
     FNDTNRKLID ANSIIRYIYG IRKLDPSNML QQELVLEWEE KILSCMIENK DISAHVSLNI
     IENRIKDGKI SSENNGANIV VFANIYDCFQ RLDGKGKAKY PGISNWFSAM LSNEKVASAI
     RIYESQTKEI LTRPEPAETN RKVNSNVAFN FDPKKIVEVK EGERNTLITS ALPYVNNIPH
     LGNIIGSVLS ADVYARYSRA RGVNTLYICG TDEYGTATET KALEENISCQ ELCDKYHKIH
     SDVYKWFNIS FDWFGRTTTP LQTEITQEMF MKVHGNDYTK TESMHQLYCE KHKRFLADRF
     VEGTCPKCGY TDARGDQCDK CGTLINAVEL IDPRCKLDGS APIVRESTHL FLDLEKLQVK
     CEMFVSNSYA KGRWSSNGLT ITKSWLNEGL KPRCITRDLK WGVPVPLEGF EDKVFYVWFD
     ACIGYISLTA NYTKNWETWW KNPNNVNLYQ FMGKDNVPFH TVVFPSTQIA TGDDYTMLHH
     ISTTEYLNYE SGKFSKSRGI GVFGNSAKDT GVDVDVWRYF LLSNRPESSD TMFTWSEFIA
     RNNNELLANL GNFCSRILKF TDSTSKYAGI LPQPSAEILG YGDSTSDSAQ VTKSFISDIN
     SLLSRYNSSL EAVSLRAGLK LAMEISARGN QYLQDSKFDN SLFTNSREAC DTVVYVCVNL
     VYLLSAVFSP YLPTVSENIC KMLNAPARLI PDEFTFDLLP GHVIGTPMHL FSQIDDKMAD
     VWRGKYGGSQ E
//

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