ID A0A2T9YQ43_9FUNG Unreviewed; 1314 AA.
AC A0A2T9YQ43;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 13-SEP-2023, entry version 23.
DE RecName: Full=tryptophan--tRNA ligase {ECO:0000256|ARBA:ARBA00013161};
DE EC=6.1.1.2 {ECO:0000256|ARBA:ARBA00013161};
DE AltName: Full=Tryptophanyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030268};
GN ORFNames=BB561_002543 {ECO:0000313|EMBL:PVU94442.1};
OS Smittium simulii.
OC Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota; Kickxellomycotina;
OC Harpellomycetes; Harpellales; Legeriomycetaceae; Smittium.
OX NCBI_TaxID=133385 {ECO:0000313|EMBL:PVU94442.1, ECO:0000313|Proteomes:UP000245383};
RN [1] {ECO:0000313|EMBL:PVU94442.1, ECO:0000313|Proteomes:UP000245383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SWE-8-4 {ECO:0000313|EMBL:PVU94442.1,
RC ECO:0000313|Proteomes:UP000245383};
RX PubMed=29764946;
RA Wang Y., Stata M., Wang W., Stajich J.E., White M.M., Moncalvo J.M.;
RT "Comparative Genomics Reveals the Core Gene Toolbox for the Fungus-Insect
RT Symbiosis.";
RL MBio 9:e00636-e00618(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004211}; Single-
CC pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}.
CC Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004200}; Single-
CC pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004200}.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594}.
CC -!- SIMILARITY: Belongs to the mitochondrial Rho GTPase family.
CC {ECO:0000256|ARBA:ARBA00007981}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVU94442.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MBFR01000090; PVU94442.1; -; Genomic_DNA.
DR STRING; 133385.A0A2T9YQ43; -.
DR Proteomes; UP000245383; Unassembled WGS sequence.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004830; F:tryptophan-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0006436; P:tryptophanyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd22209; EMC10; 1.
DR CDD; cd00806; TrpRS_core; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.240.10; Tyrosyl-Transfer RNA Synthetase; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002305; aa-tRNA-synth_Ic.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR013566; EF_hand_assoc_1.
DR InterPro; IPR013567; EF_hand_assoc_2.
DR InterPro; IPR020860; MIRO_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR002306; Trp-tRNA-ligase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR NCBIfam; TIGR00233; trpS; 1.
DR PANTHER; PTHR43766; TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43766:SF1; TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL; 1.
DR Pfam; PF08355; EF_assoc_1; 1.
DR Pfam; PF08356; EF_assoc_2; 1.
DR Pfam; PF00071; Ras; 2.
DR Pfam; PF00579; tRNA-synt_1b; 2.
DR PRINTS; PR01039; TRNASYNTHTRP.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS51423; MIRO; 2.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000245383};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 617..784
FT /note="Miro"
FT /evidence="ECO:0000259|PROSITE:PS51423"
FT DOMAIN 1113..1275
FT /note="Miro"
FT /evidence="ECO:0000259|PROSITE:PS51423"
FT REGION 1052..1075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1314 AA; 148192 MW; 71455F7F02703345 CRC64;
MASKITRVVS GIQPTGIPHI GNYLGTLQSW VNLQKDNVNK TSAIISRDSL QNAKPKSTTE
NHLKNFQNDF SKNSNISDKK LFYFLADLHS LTTLKPNLNI KQASFTSAAI ILACGLDPQT
CVFFKQSAVP SHSELMWLLS CITPMGQLNR MTSWKSKISS AAEVKPDASN VTELNSSNNI
DSITGYSGLF MYPVLQAADI LLYRPSHVPV GEDQSQHLEL TRDLAQTFNK KTKSSFFLLP
QTLLTNTKRV MSLKDPTKKM SKSDSNPKAT ILLTDSANEI KSKIMKAVTD STAEIFYDPV
NRPGISNLLE IYSALNNNGT SPEDACNTVF RGLNSQSLKT AVTDVLIQRL LPIQNEYHRL
IRDPEYINQI LDDGAEQANT FAKHFPTNGL KGDTPNQRLS REFHRPQNYG LDSKQTFSHD
ERSHSTSDTN IFSILHISSI RKLIFIASEQ LYVYDQAASS KKDFLLRGVI KYDAVAQTAH
FSPLKGSGSK NMVFEKAEKF YSELDKTIAV TDETETFTKL LSVPKHYLEA DNVDEEFNLY
FDSQDKIINL DYAAEPQVPP TFSTSVTFNK IHQGPSPKLQ KPVFIDSKTG KPEVEENQSL
ISKYWYILVL ATYFDMIDEI RVLLLGEDGT GKSSLITSFI KEEFLTNVQK TVPEVTIPPE
VTSENITTHI VDTGIEHRDR LEAEILKANV ICLIYSIVDR ESFERINSIW LPLLRSKGIN
VPVILVGNQI DRKSEVKSEY LVDSSEVLPL MRDYKEIETC IECSAKNLTN VTELFYFAQK
AVLHPVRILY DTSTRTLKHG CISALARIFW LCDKDGDGIL NYAELNEFQK TCFLSSLNET
ELADILSVVR NSLPEGVREN GLNFEGFIQL HKLFIQQGRV ETTWIVLRKF NYGDDLKIKE
ELLYPDIQVD NDCSVELSAE GFAFITQLFR RFDRDQDAAL NNIELNKLFS VIPYDNPWIE
YDFPNCTVTN NSGNVTLQGW LAMWSMVTLL DCRFTLELFG FLGYPEDTLN GITVVKKNFS
QAKIKKTNFD NNSNIHQLDH SSRNINYSND FSRSANMSSD NNRSANMLSN NSRNTNLSQN
SLNLFKNKNI LSRKLKSSKT NSFRMFSKNK SQRSTSLVYL VGSQGCGKSS LIKSFVRKIF
DSKYTPTQTP LASVNSVEIK AEQHYLVIKE FGLYTNMALS NTSILDSCDL LCMVYDSSDP
NSFQYLLDLR SHYDLNGLPT MFIATKSDLD TIAQSSTIQP DIYCKSLKLP APIFISVKTN
RIANIFEKIA ALMSKPKTVI PSLLLTKKGP TALLNIFKYS AVTSIHGFYF IQTP
//