ID   A0A2T9YQD8_9FUNG        Unreviewed;       792 AA.
AC   A0A2T9YQD8;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   22-FEB-2023, entry version 13.
DE   RecName: Full=Cullin family profile domain-containing protein {ECO:0000259|PROSITE:PS50069};
GN   ORFNames=BB561_002499 {ECO:0000313|EMBL:PVU94511.1};
OS   Smittium simulii.
OC   Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota; Kickxellomycotina;
OC   Harpellomycetes; Harpellales; Legeriomycetaceae; Smittium.
OX   NCBI_TaxID=133385 {ECO:0000313|EMBL:PVU94511.1, ECO:0000313|Proteomes:UP000245383};
RN   [1] {ECO:0000313|EMBL:PVU94511.1, ECO:0000313|Proteomes:UP000245383}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SWE-8-4 {ECO:0000313|EMBL:PVU94511.1,
RC   ECO:0000313|Proteomes:UP000245383};
RX   PubMed=29764946;
RA   Wang Y., Stata M., Wang W., Stajich J.E., White M.M., Moncalvo J.M.;
RT   "Comparative Genomics Reveals the Core Gene Toolbox for the Fungus-Insect
RT   Symbiosis.";
RL   MBio 9:e00636-e00618(2018).
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PVU94511.1}.
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DR   EMBL; MBFR01000087; PVU94511.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2T9YQD8; -.
DR   STRING; 133385.A0A2T9YQD8; -.
DR   Proteomes; UP000245383; Unassembled WGS sequence.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF169; CULLIN-1; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000245383};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          422..655
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   792 AA;  92456 MW;  334F19ADA83EBF9B CRC64;
     MTLGLMDQNN NTEKENLWEF IRAGVIQILN KTNEGLSYDR YMSIYRFSAN ILFIFITLLN
     TSNAYDFCNK PLSDYSQNSG FVVGSHRGAH LLGGQLYLKF WNELKIYNRK VLEILKDYND
     KLLLKKYETY WNRYTLAGKI LQQVFSYINR HWVKREHDEG RAVKSIFALM ISEWHNIVYQ
     SIYQSLIKIS IQEISNWRDG DIIDYKPIKT LSDSCVLISN YYSNFNEFEL QIYLNNIEKP
     VIDETENYYS QKSKLYLVDN QILNYMHKVN SILEAEKSQM ALIVHSSSQK KVISVIEAKL
     ISDHKSFFNE GFILLLENYQ VKDLLLIYSL LSRIENGLVD IQKSFELHTK QYGMNSLEKV
     STMKDGTIDP INFVETVVEV YNKYFYLTKE SFCNDPGFIT ALDRACREFI NRNKIFEKKS
     FKSSELLASY ADAILKKGSK IAIDSDFEAK FLQIINVLRY IDDKDAFQDF YRRGLARRLV
     NDQSTSHDAE QSMISKLKEI CGYDYTNKLI RMFNDMDINK DLNVDFRNLS TQQTDIDYYF
     KILNTAAWPL SSTQIDFQLP KNLSTLVNNY TDFYCQKHKG RKLNWLWQYS KMDVKITLPM
     NNTGPNHTYT FTVSTFQYAI LALFNSEDNK VHYLDINKIT GLLPYLVNNA LLVFTKCKLI
     ELVGGNMTHD AQDGGGPSFS PESIFMLNRN FKSKRLKINL NVPLRAEKKQ EVIEANRAIH
     EDHHIVIQAA IVRIMKTHKT FSHILLVNEA ISQLSKRFKP SIPEIKKAID ALIDKDYIER
     SEDNNEIYNY LA
//