ID A0A2T9Z7R1_9FUNG Unreviewed; 957 AA.
AC A0A2T9Z7R1;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
GN ORFNames=BB560_004992 {ECO:0000313|EMBL:PVV00620.1};
OS Smittium megazygosporum.
OC Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota; Kickxellomycotina;
OC Harpellomycetes; Harpellales; Legeriomycetaceae; Smittium.
OX NCBI_TaxID=133381 {ECO:0000313|EMBL:PVV00620.1, ECO:0000313|Proteomes:UP000245609};
RN [1] {ECO:0000313|EMBL:PVV00620.1, ECO:0000313|Proteomes:UP000245609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC-DP-2 {ECO:0000313|EMBL:PVV00620.1,
RC ECO:0000313|Proteomes:UP000245609};
RX PubMed=29764946;
RA Wang Y., Stata M., Wang W., Stajich J.E., White M.M., Moncalvo J.M.;
RT "Comparative Genomics Reveals the Core Gene Toolbox for the Fungus-Insect
RT Symbiosis.";
RL MBio 9:e00636-e00618(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004294}.
CC -!- SIMILARITY: Belongs to the metaxin family.
CC {ECO:0000256|ARBA:ARBA00009170}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVV00620.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MBFS01001819; PVV00620.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T9Z7R1; -.
DR STRING; 133381.A0A2T9Z7R1; -.
DR Proteomes; UP000245609; Unassembled WGS sequence.
DR GO; GO:0001401; C:SAM complex; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd03193; GST_C_Metaxin; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR019564; Sam37/metaxin_N.
DR PANTHER; PTHR12289; METAXIN RELATED; 1.
DR PANTHER; PTHR12289:SF41; METAXIN-1 HOMOLOG; 1.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF10568; Tom37; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000245609};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 73..271
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 325..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 925..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..446
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..706
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 957 AA; 107900 MW; EB0E45718DFED5A7 CRC64;
MKSAIHQYIS FTSDLIPKLM NIFDNQKTYE ETIKPEQDVQ LIIENYGTGK FWPSPMLYVP
YGSRYTDYQI FGVPLTEQLS VSKKPEPMFI AKSLSAITKM SVGFPKDEAY NFWKAPFDLA
KVHDIRYKLN TSPKITLKFF KQQDLGLVIN TLYLYLLELP DCLCTSDLYD PIKALYSIKD
DIADRLKPLS SLLSSLYPAN LVTLKAIVKT IKNLMSDDED ENRKNEFLAY VSHRLGNVVL
RPSLNSNRST HDLHPQKFFT DLVLNYEKYL ENLESTAKVT QATIPYYPEL AKPSANTRDF
SLEQNSIESF LTPKNIMSEI RSTFSLTEST DKSNRDSFSS TSSSEGDFIS SLKSGIGFFS
GKFKIKNKEN SNKQAPSKSS NIHSSVNTFH EQHQPNPVQS SPAIIEDKTI SNDAPSQELK
LAKPIENEEQ TNNDIPKEKS KNSTDSGHFS ESENIIASDT LVTKVSAIDL DPEIQNEVEN
ALKGSDKGSV HGVDDSEDHN LNQTSHFSNS LRVFVYPPFD RFKLLSDSFD PECQALVAYL
RFTDSEWEIR QAKTADIAPL GELPFFSDGL DFWESGLPHC IKYLKLQKYD LDSTLSDKEL
AISAALQSAI RSDLRDALSY EWFIVEENYY GNIKPNLVQI FGRFPAIFNI SKIWFKLIKK
LENRGWIVPK NSTSPVASKK SSVAFEKKDA SGKNNSSEAA KKQERNKAYE SAEQILKMLD
IQLGNKPFFM GDNPTTLDAI AFGYLSLAIN VELKKPALKS LIVLEFPKLL DYVSRLNMMF
YGSTPGQTTQ QVNRFDPSLN SKAKSKPLSI SLPGPDSFVS FAKASFDFLS PSLFAFVSDF
KAKALQFKTN LTKEKPSGVY NPQLNRKNTP FGTSQFLIGS LFLVLGFVSS KRIFITNEEN
ILEDASDDEE TYSFNARDIL GSISSNNEIG SDASFEDPSD LNEHSSTEFM EEFDDFH
//
