ID A0A2T9ZC08_9FUNG Unreviewed; 466 AA.
AC A0A2T9ZC08;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 22-FEB-2023, entry version 18.
DE RecName: Full=Hsp90 chaperone protein kinase-targeting subunit {ECO:0000256|ARBA:ARBA00031396};
GN ORFNames=BB560_003420 {ECO:0000313|EMBL:PVV02134.1};
OS Smittium megazygosporum.
OC Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota; Kickxellomycotina;
OC Harpellomycetes; Harpellales; Legeriomycetaceae; Smittium.
OX NCBI_TaxID=133381 {ECO:0000313|EMBL:PVV02134.1, ECO:0000313|Proteomes:UP000245609};
RN [1] {ECO:0000313|EMBL:PVV02134.1, ECO:0000313|Proteomes:UP000245609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC-DP-2 {ECO:0000313|EMBL:PVV02134.1,
RC ECO:0000313|Proteomes:UP000245609};
RX PubMed=29764946;
RA Wang Y., Stata M., Wang W., Stajich J.E., White M.M., Moncalvo J.M.;
RT "Comparative Genomics Reveals the Core Gene Toolbox for the Fungus-Insect
RT Symbiosis.";
RL MBio 9:e00636-e00618(2018).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the CDC37 family.
CC {ECO:0000256|ARBA:ARBA00006222}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVV02134.1}.
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DR EMBL; MBFS01000596; PVV02134.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T9ZC08; -.
DR STRING; 133381.A0A2T9ZC08; -.
DR Proteomes; UP000245609; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR Gene3D; 1.20.58.610; Cdc37, Hsp90 binding domain; 1.
DR InterPro; IPR004918; Cdc37.
DR InterPro; IPR013873; Cdc37_C.
DR InterPro; IPR013874; Cdc37_Hsp90-bd.
DR InterPro; IPR038189; Cdc37_Hsp90-bd_sf.
DR InterPro; IPR013855; Cdc37_N_dom.
DR PANTHER; PTHR12800; CDC37-RELATED; 1.
DR PANTHER; PTHR12800:SF4; HSP90 CO-CHAPERONE CDC37; 1.
DR Pfam; PF08564; CDC37_C; 1.
DR Pfam; PF08565; CDC37_M; 1.
DR Pfam; PF03234; CDC37_N; 1.
DR SMART; SM01069; CDC37_C; 1.
DR SMART; SM01070; CDC37_M; 1.
DR SMART; SM01071; CDC37_N; 1.
DR SUPFAM; SSF101391; Hsp90 co-chaperone CDC37; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000245609}.
FT DOMAIN 2..198
FT /note="Cdc37 N-terminal"
FT /evidence="ECO:0000259|SMART:SM01071"
FT DOMAIN 196..373
FT /note="Cdc37 Hsp90 binding"
FT /evidence="ECO:0000259|SMART:SM01070"
FT DOMAIN 390..465
FT /note="Cdc37 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01069"
FT REGION 222..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 49..79
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 241..258
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 466 AA; 53576 MW; 941C65BE6ECC7CA6 CRC64;
MPIDYSKWDN LEISDDSDVE IHPNIEKGTF IRLRQQKIRQ DRERRAHTVR ALESELEMNK
KLAARLSEMI SEIKEESKEQ FAARMLDWSA KAEKQEAILN DVRKALEANE EYRQLEFDEL
VDTLVYRVQQ ELAKSEVITQ QNANPDIIKL KVIDLLHGHI EKLKNRDPEA RAEIENIKKE
QRMHISADEV AKEGYNKTFI NKQPKASTSS SKNNVQSVEL LNPGYEKNIK PEAEVPENTE
SLEGNNDEDS DEESLTVDPD SMEFGMIDSL DKSKDYILEH RHIIGQNKSD QLLVQAFRYQ
MRGESELAKQ FVRQSLILTY IHQMGPSGIN IFFSKIVIKG NPGNVMFFND IEKRYNHIVE
RCKILKKEQE TSQIESIQLQ TDSPDSTIRT YVPDKSNPDD KEKWALFEQL PVDFQEALKT
GTIDAINQAL AKIPGSKAEE ILQTCGKGGF LVIDEEILVD ADQQEL
//
