ID A0A2T9ZKT1_9FUNG Unreviewed; 886 AA.
AC A0A2T9ZKT1;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=DNA mismatch repair protein S5 domain-containing protein {ECO:0000259|SMART:SM01340};
GN ORFNames=BB560_000347 {ECO:0000313|EMBL:PVV05137.1};
OS Smittium megazygosporum.
OC Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota; Kickxellomycotina;
OC Harpellomycetes; Harpellales; Legeriomycetaceae; Smittium.
OX NCBI_TaxID=133381 {ECO:0000313|EMBL:PVV05137.1, ECO:0000313|Proteomes:UP000245609};
RN [1] {ECO:0000313|EMBL:PVV05137.1, ECO:0000313|Proteomes:UP000245609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC-DP-2 {ECO:0000313|EMBL:PVV05137.1,
RC ECO:0000313|Proteomes:UP000245609};
RX PubMed=29764946;
RA Wang Y., Stata M., Wang W., Stajich J.E., White M.M., Moncalvo J.M.;
RT "Comparative Genomics Reveals the Core Gene Toolbox for the Fungus-Insect
RT Symbiosis.";
RL MBio 9:e00636-e00618(2018).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVV05137.1}.
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DR EMBL; MBFS01000035; PVV05137.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2T9ZKT1; -.
DR STRING; 133381.A0A2T9ZKT1; -.
DR Proteomes; UP000245609; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000245609}.
FT DOMAIN 230..351
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 435..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 886 AA; 99360 MW; B4D0C993F801EA64 CRC64;
MENIASKQKP KHIKKLDNSV INRIAAGEII HRPSNALKEL LENSLDANAS QIQVLAKDGG
MKLLQIIDNG HGINREDLPL LCERFTTSKI QAYEDLEKIS TYGFRGEALA SISHVAHLSV
ITKTSDSSCA YKAKYIDGAL SAGGSSEDSE PKPCAGNDGT QIIVENLFYN IPYRKQALKK
TNEEYSRILD VVGKYAIHNA GVAMSCRKIG PKTIGNDVQT SKESSKPEII RQIYGRSIAD
SLEKFEKDLS ESVLATRFDG YASNGIFSCK KTTLLLFINN RLVENSSIRS SVEQLYSSTF
PKSPKPFVYL SISIRPEYVD VNVHPTKKEV HFLNQDQIII EVVNAIQQVL MHSNNSQVLT
VQNPGRTVLS FIDSDITTDI NKESPKKEFS SLSKSMDSKK NDAIYYSPRK VHESKLVRMD
SKNFSLKSFI FDAGSGKPSQ NGDPYRKRET FGSPLGFRST NQKKFVEDNN SNSTNSFDTD
KDSLSPVTTS KKMIESPTPS HSNLSSFYTK LMGSTANDNA SIDMVNTLNS DSGDFISSDD
YRKISNMLTK SNTTTETVSV VDSATDPTSL KNKKSEEFEV SEKKRPRVEV KLSSILELRN
EWAEIAHNQF TKILHDHIFV GIVDTTRALV QHGTSLYMVD FEQVSEALFY QLALTEFCNF
GRIELNPSPK LYDLVLLALG KEIEYDGLIR SKVKDTGYFQ NEDFDPIPEE IVSSPDGVAL
AIVELIVSRR EMLLEYYNFS VTEDGLLESI PMMLREYVPN MTKLPLFLLR IGSEVNWEDE
KIFFKEFSSE LAYFYATEPP TEIQDETLAE NGDNTISLKM RIRSQPENTG LESSESDAMK
QFYHAVEYRL FPALKAGFNA PASLVASNSV HLIANLPDLY KIFERC
//
