ID A0A2U0HW73_9FLAO Unreviewed; 775 AA.
AC A0A2U0HW73;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=DDV96_14245 {ECO:0000313|EMBL:PVW13112.1};
OS Marixanthomonas spongiae.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Marixanthomonas.
OX NCBI_TaxID=2174845 {ECO:0000313|EMBL:PVW13112.1, ECO:0000313|Proteomes:UP000245962};
RN [1] {ECO:0000313|EMBL:PVW13112.1, ECO:0000313|Proteomes:UP000245962}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HN-E44 {ECO:0000313|EMBL:PVW13112.1,
RC ECO:0000313|Proteomes:UP000245962};
RA Luo L., Zhuang L.;
RT "Marixanthomonas spongiae HN-E44 sp. nov., isolated from a marine sponge.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVW13112.1}.
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DR EMBL; QEHR01000011; PVW13112.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U0HW73; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000245962; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000245962}.
FT DOMAIN 6..291
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 292..573
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 27..34
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 775 AA; 88694 MW; B29197FC2D211F68 CRC64;
MQEYLQQLND AQRAPVLQKD GAMIVIAGAG SGKTRVLTYR IAYLMSQGVD PFNILALTFT
NKAAREMKGR ISQIVGSSEA KNLWMGTFHS VFAKILRFEG HRLGYPSNFT IYDTQDSHSV
IRAVIKEMQL DKDVYKYKQV YSRISSYKNS LITVKAYFNN PELMEADAMA KMPRLGDIYN
NYVERCFKAG AMDFDDLLLK TNELLTRFPE VLAHYQNRFR YILVDEYQDT NHSQYLIVKA
LSDRFQNICV VGDDAQSIYA FRGANINNIL NFQKDYDDVT VYRLEQNYRS TKNIVNAANS
IIEKNKTRLE KIVWTANDEG NKIKVNRTMT DGDEGRFVAS SIFETAMNNQ LNYSDFAVLY
RTNAQSRAVE DALRKRDIPY RIYGGLSFYQ RKEIKDVIAY LRLILNPKDE EALKRVINYP
ARGIGQTTME RLTVAANHYN RAIFEVMQNL DKINLKINKG TQGKLEDFVT MIKSFQILNK
NQNAFQVAEH VAKKTGLLQE LKKDGTPEGI ARIENIEELL NGMRDFVEEQ KELADTTGSL
AEFLEDVALA TDLDNEKGDD NKVALMTVHL AKGLEFPYVY IVGMEEDLFP SGMNMNSRAE
LEEERRLFYV ALTRAEKQAY LTYTQSRYRW GKLIDAEPSR FIEEIEESFL EYLTPKTENR
FKPLIDADIF DEVDKSKLRL KKPKAGTPPK KNGPTEAQLR KLRRLKPVSS DTNKNFDPKA
ANLDVGTKVE HVRFGKGKIL SIEGKGADTK AEIQFDNGGL KKLLLRFAKL EVLSS
//
