ID A0A2U0I2C8_9FLAO Unreviewed; 1863 AA.
AC A0A2U0I2C8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Alpha-2-macroglobulin {ECO:0008006|Google:ProtNLM};
GN ORFNames=DDV96_07590 {ECO:0000313|EMBL:PVW15259.1};
OS Marixanthomonas spongiae.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Marixanthomonas.
OX NCBI_TaxID=2174845 {ECO:0000313|EMBL:PVW15259.1, ECO:0000313|Proteomes:UP000245962};
RN [1] {ECO:0000313|EMBL:PVW15259.1, ECO:0000313|Proteomes:UP000245962}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HN-E44 {ECO:0000313|EMBL:PVW15259.1,
RC ECO:0000313|Proteomes:UP000245962};
RA Luo L., Zhuang L.;
RT "Marixanthomonas spongiae HN-E44 sp. nov., isolated from a marine sponge.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVW15259.1}.
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DR EMBL; QEHR01000004; PVW15259.1; -; Genomic_DNA.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000245962; Unassembled WGS sequence.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 2.60.40.3710; -; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041462; Bact_A2M_MG6.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR032812; SbsA_Ig.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF13205; Big_5; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF17962; bMG6; 1.
DR Pfam; PF01835; MG2; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000245962};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1863
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015414056"
FT DOMAIN 1002..1144
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 1207..1298
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1863 AA; 208873 MW; 5E4AD5269DE757AB CRC64;
MRNLSFFLAL IAILFLSACG DKKPSETDNL FKFKDYISYN TYGNKSIADP IRIELQKPLD
QFELTQEIDR KYLTISPSTE GTLTIENGRT LVFTPAEYLK PDTEYTITVK LSKLYDNVEK
EFKDYTFSFK TITPNFKVDL GNLQSYSKKW QYINGYLETS DIITLEKAKK LVQVNQGDKK
LKLQWPSEGD YATYFSFTID SIQRKMDDSE IKISWNGDAI DAETKGENTF KIPGQNNFTV
IDVESTLSPQ TSLAINFSDP LKENQDFAGL VTIDSIQNLS YEVNGNVLNI YPSTRITGDA
RVTVFNGIKN IENFGLKKEF SELVSFEELK PAVRLISKGT VLPNATSTPF YFETVNLSAI
DVRIIKIYQD NILQYLQTAD LNSNNVYDIK RVGRRIAKKT INLTENSVGS NSTWKAHALN
LSEFFKADPG AIYRVELSFK KSYTTYDCSG NTTEATEEDD YYANADDTYE DEQEEKYWNN
EIYRWRDYTY NWQERDNPCH AAYYNQDRII SSNVIGSDLG LIVKESSNRS YHFITNNLVT
TKPESGVKIK LYNYQQQLVE TVTTDAEGMT LYDSEKNIAF AVAQKGKNYA YAKLEDGKAL
SMSKFDVSGK QLQKGIKGFL YTERGVHRPG DSIHLTFVLS DVANPLPKNH PVKLEVTDAR
GKLVQRSVLN GTKFSPFGGD AEGRGGESGM FRSKEGFYYF PIPTQPSAPT GNWNATVTVG
GVQFTKSLKV ATVKPNRLKI KLDFDDDILD ASKPIKGTAN AAWLHGAPAR NLKIEMDATL
RTTSTAFKNY PNYQFNDPVR TFNEVEIPVL DTKLSSKGTT SFSKDFEVSG KAPGMLQATF
LTKVFEGGGD FSIDVFSKNL APYSHFVGLR SPEAHKYGSY FTDENTVFDV ATVDAQGNAS
PNREVEVKVF RIEWRWWWNR GNDNLSRYEN ATVHKPVKDF KVTTNSKGKA NFTINIPEEE
GGRYLIRVID KKSGHATGRV AYFYRNWWKA PVDGEAESAK MLVFSADKEK YNVGEEAFIT
FPSGSEGRAL ISVENGTEVL ATHWIETKKG ETKAAIRLTK EMTPNIYVNI SLLQPHEQTK
NDLPIRLYGV IPILVEDAST VLKPEINMPN VLKPEENFTV KVSEANNKPM TYTLAMVDEG
LLDLTRFKTP EIHKAFYTRE ALGVKTFDMY DDVIGAYSGS VDNIYAIGGG DVAAGAKNRK
ADRFKPVVKY VGPFKLKAGE TASHTLTMPN YVGSVRTMVI AGDNSKSAYG KIDETTPVRK
PLMVLASLPR KLSPGEKVTL PVTVFAMEEK VKNATITVKT GDGLKPINGT SKTISFPSVG
EKIVNFEFDV LPTSKIQTIE VLASGSGEKA SYKVEIDVEN PNPISQKASQ YTLTENGTET
INFETFGVSG SNGAMLEFST VPPMDFGKRM EYLIRYPHGC VEQITSGAFP QLYLADVFDI
TFDKKKDIQK NVETAIRKLG NYQNTSGGLS YWPGEREADP WSTNYVGHFM LEAKQKGYAL
PISFLNNWLQ FQKNAARQWR NSSTSYNSSL TQAYRLYTLA LAGQPELAAM NRLRESKHLS
NDAKWRLAAA YALAGKRNVA EQISQTANIN FEPKRYNYYT YGSPFRNKAM ALETMVALGD
NKQREMAVSV AKELSSQRWY STQETAYALL AMAKMINKNG GKAMELTYTD NGKTKIVKTD
RAVAQRELSF TMGDNSVSVS NKKGNVVYVT LIQQGKLPLG KELAERKNLT IQAQYLDGTG
KSIDVSKLRQ GTEISATVTV TNISNDHINN VALTKISPSG WEIVNTSFTE LGGGASGKAR
YTDIRDDRVN FYFDLRAKKS KTFTIKLNAS YLGTYYLPGT QVEAMYDRNY YARNKGMWVE
VVK
//
